EA201992076A1 - BETA-SECRETASE INHIBITORS - Google Patents

BETA-SECRETASE INHIBITORS

Info

Publication number
EA201992076A1
EA201992076A1 EA201992076A EA201992076A EA201992076A1 EA 201992076 A1 EA201992076 A1 EA 201992076A1 EA 201992076 A EA201992076 A EA 201992076A EA 201992076 A EA201992076 A EA 201992076A EA 201992076 A1 EA201992076 A1 EA 201992076A1
Authority
EA
Eurasian Patent Office
Prior art keywords
beta
dementia
compounds
dementia associated
disease
Prior art date
Application number
EA201992076A
Other languages
Russian (ru)
Inventor
Анн Марлен Вос
Дэниел Оельрих
Хенрикус Якобус Мария Гейсен
Карл Шон Уоттс
Сатеш Пангала Бхат
Франс Альфонс Мария Ван Ден Кейбюс
Original Assignee
Янссен Фармацевтика Нв
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Нв filed Critical Янссен Фармацевтика Нв
Publication of EA201992076A1 publication Critical patent/EA201992076A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Настоящее изобретение относится к трициклическим ингибиторам бета-секретазы, имеющим структуру, показанную в виде формул (I) и (II)и к их таутомерам и стереоизомерным формам, при этом радикалы определены в описании. Настоящее изобретение также относится к фармацевтическим композициям, содержащим такие соединения, к способам получения таких соединений и композиций и к применению таких соединений и композиций для предупреждения и лечения расстройств, в которые вовлечена бета-секретаза, таких как болезнь Альцгеймера (AD), умеренное когнитивное нарушение, угасание, деменция, деменция с тельцами Леви, синдром Дауна, деменция, ассоциированная с инсультом, деменция, ассоциированная с болезнью Паркинсона, деменция, ассоциированная с накоплением бета-амилоида, возрастная макулярная дегенерация, диабет 2 типа и другие нарушения обмена веществ.The present invention relates to tricyclic beta-secretase inhibitors having the structure shown in the form of formulas (I) and (II) and their tautomers and stereoisomeric forms, with radicals defined in the description. The present invention also relates to pharmaceutical compositions containing such compounds, to methods for producing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders involving beta-secretase, such as Alzheimer's disease (AD), mild cognitive impairment , extinction, dementia, dementia with Levi bodies, Down syndrome, dementia associated with stroke, dementia associated with Parkinson's disease, dementia associated with accumulation of beta-amyloid, age-related macular degeneration, type 2 diabetes and other metabolic disorders.

EA201992076A 2017-09-07 2018-03-06 BETA-SECRETASE INHIBITORS EA201992076A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17189762 2017-09-07
PCT/EP2018/055401 WO2018162443A1 (en) 2017-03-07 2018-03-06 Inhibitors of beta secretase

Publications (1)

Publication Number Publication Date
EA201992076A1 true EA201992076A1 (en) 2020-03-19

Family

ID=59811157

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201992076A EA201992076A1 (en) 2017-09-07 2018-03-06 BETA-SECRETASE INHIBITORS

Country Status (2)

Country Link
EA (1) EA201992076A1 (en)
WO (1) WO2018162443A1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR077277A1 (en) * 2009-07-09 2011-08-17 Lilly Co Eli BICYCLE COMPOUNDS (1,3) TIAZIN-2-AMINA PHARMACEUTICAL FORMULATION THAT INCLUDES IT AND ITS USE FOR THE MANUFACTURE OF A USEFUL MEDICINAL PRODUCT FOR THE TREATMENT OF ALZHEIMER'S DISEASE
JPWO2011071109A1 (en) * 2009-12-11 2013-04-22 塩野義製薬株式会社 Fused heterocyclic compounds having an amino group
US9556135B2 (en) * 2012-10-12 2017-01-31 Amgen, Inc. Amino-dihydrothiazine and amino-dioxido dihydrothiazine compounds as beta-secretase antagonists and methods of use

Also Published As

Publication number Publication date
WO2018162443A1 (en) 2018-09-13

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