EA201992044A2 - Цитотоксические бензодиазепиновые производные - Google Patents

Цитотоксические бензодиазепиновые производные

Info

Publication number
EA201992044A2
EA201992044A2 EA201992044A EA201992044A EA201992044A2 EA 201992044 A2 EA201992044 A2 EA 201992044A2 EA 201992044 A EA201992044 A EA 201992044A EA 201992044 A EA201992044 A EA 201992044A EA 201992044 A2 EA201992044 A2 EA 201992044A2
Authority
EA
Eurasian Patent Office
Prior art keywords
benzodiazepine derivatives
compounds
conjugates
cytotoxic benzodiazepine
benzodiazepine
Prior art date
Application number
EA201992044A
Other languages
English (en)
Other versions
EA039619B1 (ru
EA201992044A3 (ru
Inventor
Рави В. Дж. Чари
Майкл Луис Миллер
Манами Шизука
Original Assignee
Иммуноджен, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Иммуноджен, Инк. filed Critical Иммуноджен, Инк.
Publication of EA201992044A2 publication Critical patent/EA201992044A2/ru
Publication of EA201992044A3 publication Critical patent/EA201992044A3/ru
Publication of EA039619B1 publication Critical patent/EA039619B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Изобретение относится к новым бензодиазепиновым производным, обладающим антипролиферативной активностью, более конкретно к новым бензодиазепиновым соединениям формул (I)-(VI). Изобретение также предлагает конъюгаты бензодиазепиновых соединений, присоединенных к связывающемуся с клетками агенту. Кроме того, изобретение предлагает композиции и способы, пригодные для угнетения аномального роста клеток или лечения пролиферативного расстройства у млекопитающего с использованием соединений или конъюгатов по изобретению.
EA201992044A 2015-05-20 2015-09-02 Способ получения индолинобензодиазепиновых соединений EA039619B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562164305P 2015-05-20 2015-05-20

Publications (3)

Publication Number Publication Date
EA201992044A2 true EA201992044A2 (ru) 2020-01-09
EA201992044A3 EA201992044A3 (ru) 2020-02-28
EA039619B1 EA039619B1 (ru) 2022-02-17

Family

ID=69374494

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201992044A EA039619B1 (ru) 2015-05-20 2015-09-02 Способ получения индолинобензодиазепиновых соединений

Country Status (1)

Country Link
EA (1) EA039619B1 (ru)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2010210646B2 (en) * 2009-02-05 2015-10-29 Immunogen, Inc. Novel benzodiazepine derivatives
SI2675479T1 (sl) * 2011-02-15 2016-04-29 Immunogen, Inc. Citotoksični derivati benzodiazepina

Also Published As

Publication number Publication date
EA039619B1 (ru) 2022-02-17
EA201992044A3 (ru) 2020-02-28

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