EA201992001A1 - COMPOSITIONS AND METHODS FOR INCREASING GENE EXPRESSION - Google Patents
COMPOSITIONS AND METHODS FOR INCREASING GENE EXPRESSIONInfo
- Publication number
- EA201992001A1 EA201992001A1 EA201992001A EA201992001A EA201992001A1 EA 201992001 A1 EA201992001 A1 EA 201992001A1 EA 201992001 A EA201992001 A EA 201992001A EA 201992001 A EA201992001 A EA 201992001A EA 201992001 A1 EA201992001 A1 EA 201992001A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methods
- gene expression
- compositions
- increasing gene
- increasing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
В настоящем изобретении предложены полинуклеотидные кассеты, векторы экспрессии и способы экспрессии гена в клетках млекопитающих.The present invention provides polynucleotide cassettes, expression vectors and methods for gene expression in mammalian cells.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762472892P | 2017-03-17 | 2017-03-17 | |
PCT/US2018/022996 WO2018170473A1 (en) | 2017-03-17 | 2018-03-16 | Compositions and methods for enhanced gene expression |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201992001A1 true EA201992001A1 (en) | 2020-01-24 |
Family
ID=63523675
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201992001A EA201992001A1 (en) | 2017-03-17 | 2018-03-16 | COMPOSITIONS AND METHODS FOR INCREASING GENE EXPRESSION |
Country Status (13)
Country | Link |
---|---|
US (3) | US11773406B2 (en) |
EP (1) | EP3596213A4 (en) |
JP (2) | JP7343903B2 (en) |
KR (1) | KR102616820B1 (en) |
CN (1) | CN110546257B (en) |
AU (1) | AU2018234918B2 (en) |
BR (1) | BR112019019158A2 (en) |
CA (1) | CA3054942A1 (en) |
EA (1) | EA201992001A1 (en) |
IL (1) | IL268788A (en) |
MX (1) | MX2019011040A (en) |
SG (1) | SG11201907653QA (en) |
WO (1) | WO2018170473A1 (en) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2015231439B2 (en) | 2014-03-17 | 2019-11-14 | Adverum Biotechnologies, Inc. | Compositions and methods for enhanced gene expression in cone cells |
SG11201707063TA (en) | 2015-03-02 | 2017-09-28 | Adverum Biotechnologies Inc | Compositions and methods for intravitreal delivery of polynucleotides to retinal cones |
GB2545763A (en) | 2015-12-23 | 2017-06-28 | Adverum Biotechnologies Inc | Mutant viral capsid libraries and related systems and methods |
US11192925B2 (en) | 2016-10-19 | 2021-12-07 | Adverum Biotechnologies, Inc. | Modified AAV capsids and uses thereof |
MX2019011040A (en) | 2017-03-17 | 2020-01-20 | Adverum Biotechnologies Inc | Compositions and methods for enhanced gene expression. |
CN112585267A (en) * | 2018-08-02 | 2021-03-30 | 诺维信公司 | Preparation of a combinatorial library of DNA constructs Using introns |
WO2020180951A1 (en) | 2019-03-04 | 2020-09-10 | Adverum Biotechnologies, Inc. | Sequential intravitreal administration of aav gene therapy to contralateral eyes |
US20210100856A1 (en) * | 2019-09-11 | 2021-04-08 | Adverum Biotechnologies, Inc. | Methods of treating ocular neovascular diseases using aav2 variants encoding aflibercept |
JP2022547541A (en) | 2019-09-11 | 2022-11-14 | アドヴェラム バイオテクノロジーズ, インコーポレイテッド | Methods of treating intraocular neovascular diseases using AAV2 variants encoding aflibercept |
BR112022003206A2 (en) * | 2019-09-11 | 2022-08-16 | Adverum Biotechnologies Inc | METHODS TO TREAT NEOVASCULAR EYE DISEASES USING AAV2 VARIANTS ENCODING AFLIBERCEPTE |
KR102346159B1 (en) * | 2020-02-20 | 2022-01-03 | 국립암센터 | High Efficiency Expression Vector and Uses thereof |
US20220010332A1 (en) * | 2020-07-08 | 2022-01-13 | Neuracle Genetics Inc. | Intron fragments |
CN113817775B (en) * | 2020-08-25 | 2023-02-17 | 南京吉迈生物技术有限公司 | Modified aflibercept, compositions, methods and uses thereof in gene therapy |
EP4288064A2 (en) * | 2021-02-02 | 2023-12-13 | Allen Institute | Artificial expression constructs for modulating gene expression in gabaergic neurons and astrocytes |
JP2024515459A (en) | 2021-04-27 | 2024-04-10 | アドヴェラム バイオテクノロジーズ, インコーポレイテッド | Methods of Treating Ocular Diseases Using AAV2 Variants Encoding Aflibercept |
WO2023283649A1 (en) * | 2021-07-08 | 2023-01-12 | Tenaya Therapeutics, Inc. | Optimized expression cassettes for gene therapy |
WO2023147604A2 (en) * | 2022-01-31 | 2023-08-03 | Trames Bio, Inc. | Expression cassettes for treating epilepsy and neuropathic pain |
WO2023150566A1 (en) | 2022-02-02 | 2023-08-10 | Adverum Biotechnologies, Inc. | Methods of treating ocular neovascular diseases using aav2 variants encoding aflibercept |
WO2023158990A1 (en) | 2022-02-16 | 2023-08-24 | Adverum Biotechnologies, Inc. | Method of reducing cst fluctuation in neovascular amd by a recombinant adeno-associated virus |
WO2023225455A2 (en) * | 2022-05-18 | 2023-11-23 | Visgenx, Inc. | Synthetic aav genomes for improved gene delivery |
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US5436146A (en) | 1989-09-07 | 1995-07-25 | The Trustees Of Princeton University | Helper-free stocks of recombinant adeno-associated virus vectors |
EP0694042B1 (en) | 1993-03-25 | 2004-11-03 | Merck & Co. Inc. | Inhibitor of vascular endothelial cell growth factor |
US20020168342A1 (en) | 1994-11-03 | 2002-11-14 | Cell Genesys, Inc. | Novel adenoviral vectors, packaging cell lines, recombinant adenoviruses and methods |
US6040183A (en) | 1995-06-07 | 2000-03-21 | University Of North Carloina At Chapel Hill | Helper virus-free AAV production |
US6093570A (en) | 1995-06-07 | 2000-07-25 | The University Of North Carolina At Chapel Hill | Helper virus-free AAV production |
US6087129A (en) | 1996-01-19 | 2000-07-11 | Betagene, Inc. | Recombinant expression of proteins from secretory cell lines |
ES2224375T3 (en) | 1997-04-14 | 2005-03-01 | Cell Genesys, Inc. | METHODS TO INCREASE THE EFFECTIVENESS OF THE RECOMBINANT AAV PRODUCT. |
US7087411B2 (en) | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
ATE527347T1 (en) | 2001-08-02 | 2011-10-15 | Inst Clayton De La Rech | METHODS AND COMPOSITIONS RELATED TO IMPROVED LENTIVIRUS VECTOR PRODUCTION SYSTEMS |
US8021875B2 (en) * | 2001-08-27 | 2011-09-20 | Roche Madison Inc. | Methods for expression of transgenes |
AU2003223775A1 (en) | 2002-04-30 | 2003-11-17 | Duke University | Adeno-associated viral vectors and methods for their production from hybrid adenovirus and for their use |
WO2004007664A2 (en) * | 2002-05-28 | 2004-01-22 | Maxygen, Inc. | Nucleic acid vectors |
GB0220467D0 (en) | 2002-09-03 | 2002-10-09 | Oxford Biomedica Ltd | Composition |
CN1771324A (en) * | 2003-02-03 | 2006-05-10 | 日本免疫股份有限公司 | High-expression vector for animal cells |
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TWI698240B (en) | 2012-05-15 | 2020-07-11 | 澳大利亞商艾佛蘭屈澳洲私營有限公司 | Treatment of amd using aav sflt-1 |
WO2014194132A1 (en) | 2013-05-31 | 2014-12-04 | The Regents Of The University Of California | Adeno-associated virus variants and methods of use thereof |
CN106163573A (en) | 2014-02-06 | 2016-11-23 | 建新公司 | For treating and preventing composition and the method for macular degeneration |
AU2015231439B2 (en) | 2014-03-17 | 2019-11-14 | Adverum Biotechnologies, Inc. | Compositions and methods for enhanced gene expression in cone cells |
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RU2716991C2 (en) * | 2014-11-05 | 2020-03-17 | Вояджер Терапьютикс, Инк. | Aadc polynucleotides for treating parkinson's disease |
SG11201707063TA (en) | 2015-03-02 | 2017-09-28 | Adverum Biotechnologies Inc | Compositions and methods for intravitreal delivery of polynucleotides to retinal cones |
JP6544565B2 (en) | 2015-04-28 | 2019-07-17 | 国立大学法人広島大学 | Method and kit for enhancing expression of target gene in mammalian cells and use thereof |
GB2545763A (en) | 2015-12-23 | 2017-06-28 | Adverum Biotechnologies Inc | Mutant viral capsid libraries and related systems and methods |
AU2017257169B2 (en) | 2016-04-29 | 2021-07-08 | Adverum Biotechnologies, Inc. | Evasion of neutralizing antibodies by a recombinant adeno-associated virus |
KR102218265B1 (en) | 2016-06-16 | 2021-02-25 | 애드베룸 바이오테크놀로지스, 인코포레이티드 | Treatment of AMD using the AAV2 variant with aflibercept |
DK3472317T3 (en) | 2016-06-16 | 2022-05-23 | Adverum Biotechnologies Inc | COMPOSITIONS AND PROCEDURES TO REDUCE OCULAR VASCULARIZATION |
US11192925B2 (en) | 2016-10-19 | 2021-12-07 | Adverum Biotechnologies, Inc. | Modified AAV capsids and uses thereof |
CA3054687A1 (en) | 2017-02-28 | 2018-09-07 | Adverum Biotechnologies, Inc. | Modified aav capsids and uses thereof |
MX2019011040A (en) | 2017-03-17 | 2020-01-20 | Adverum Biotechnologies Inc | Compositions and methods for enhanced gene expression. |
-
2018
- 2018-03-16 MX MX2019011040A patent/MX2019011040A/en unknown
- 2018-03-16 US US16/494,203 patent/US11773406B2/en active Active
- 2018-03-16 WO PCT/US2018/022996 patent/WO2018170473A1/en unknown
- 2018-03-16 BR BR112019019158A patent/BR112019019158A2/en unknown
- 2018-03-16 JP JP2019545767A patent/JP7343903B2/en active Active
- 2018-03-16 KR KR1020197024645A patent/KR102616820B1/en active IP Right Grant
- 2018-03-16 SG SG11201907653QA patent/SG11201907653QA/en unknown
- 2018-03-16 AU AU2018234918A patent/AU2018234918B2/en active Active
- 2018-03-16 CN CN201880025331.7A patent/CN110546257B/en active Active
- 2018-03-16 EP EP18768324.8A patent/EP3596213A4/en active Pending
- 2018-03-16 EA EA201992001A patent/EA201992001A1/en unknown
- 2018-03-16 CA CA3054942A patent/CA3054942A1/en active Pending
-
2019
- 2019-08-19 IL IL26878819A patent/IL268788A/en unknown
-
2020
- 2020-08-20 US US16/998,540 patent/US11352644B2/en active Active
-
2022
- 2022-04-15 JP JP2022067534A patent/JP7360208B2/en active Active
-
2023
- 2023-04-26 US US18/307,256 patent/US20230257777A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CN110546257A (en) | 2019-12-06 |
WO2018170473A1 (en) | 2018-09-20 |
US11352644B2 (en) | 2022-06-07 |
JP2020513792A (en) | 2020-05-21 |
MX2019011040A (en) | 2020-01-20 |
NZ756504A (en) | 2023-11-24 |
IL268788A (en) | 2019-10-31 |
AU2018234918B2 (en) | 2023-11-02 |
SG11201907653QA (en) | 2019-09-27 |
CN110546257B (en) | 2024-03-01 |
EP3596213A4 (en) | 2021-02-17 |
BR112019019158A2 (en) | 2020-05-05 |
CA3054942A1 (en) | 2018-09-20 |
US20230257777A1 (en) | 2023-08-17 |
JP7360208B2 (en) | 2023-10-12 |
KR20190132626A (en) | 2019-11-28 |
JP2022092057A (en) | 2022-06-21 |
JP7343903B2 (en) | 2023-09-13 |
US20210040501A1 (en) | 2021-02-11 |
AU2018234918A1 (en) | 2019-09-12 |
KR102616820B1 (en) | 2023-12-21 |
EP3596213A1 (en) | 2020-01-22 |
US20200010851A1 (en) | 2020-01-09 |
US11773406B2 (en) | 2023-10-03 |
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