EA201991877A2 - 7-BENZyl-4- (2-methylbenzyl) -2,4,6,7,8,9-hexahydroimidazo [1,2-A] pyrido [3,4-E] pyrimidine-5 (1H) -OH, its SALTS AND METHODS OF APPLICATION - Google Patents
7-BENZyl-4- (2-methylbenzyl) -2,4,6,7,8,9-hexahydroimidazo [1,2-A] pyrido [3,4-E] pyrimidine-5 (1H) -OH, its SALTS AND METHODS OF APPLICATIONInfo
- Publication number
- EA201991877A2 EA201991877A2 EA201991877A EA201991877A EA201991877A2 EA 201991877 A2 EA201991877 A2 EA 201991877A2 EA 201991877 A EA201991877 A EA 201991877A EA 201991877 A EA201991877 A EA 201991877A EA 201991877 A2 EA201991877 A2 EA 201991877A2
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- hexahydroimidazo
- pyrido
- methylbenzyl
- pyrimidine
- benzyl
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Настоящее изобретение относится, по меньшей мере частично, к способу лечения. В одном варианте реализации способ лечения включает введение субъекту, нуждающемуся в таком лечении, первого терапевтического агента, включающего соединение (1)или его фармацевтически приемлемую соль, в комбинации со вторым терапевтическим агентом, при этом указанные первый терапевтический агент и второй терапевтический агент вводят одновременно или последовательно.The present invention relates, at least in part, to a method of treatment. In one embodiment, the treatment method comprises administering to a subject in need of such treatment a first therapeutic agent comprising a compound (1) or a pharmaceutically acceptable salt thereof, in combination with a second therapeutic agent, wherein said first therapeutic agent and a second therapeutic agent are administered simultaneously or sequentially.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361904718P | 2013-11-15 | 2013-11-15 | |
PCT/US2014/048241 WO2015073072A1 (en) | 2013-11-15 | 2014-07-25 | 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201991877A2 true EA201991877A2 (en) | 2020-01-31 |
EA201991877A3 EA201991877A3 (en) | 2020-05-31 |
Family
ID=53057834
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201991877A EA201991877A3 (en) | 2013-11-15 | 2014-09-12 | 7-BENZyl-4- (2-methylbenzyl) -2,4,6,7,8,9-hexahydroimidazo [1,2-A] pyrido [3,4-E] pyrimidine-5 (1H) -OH, its SALTS AND APPLICATIONS |
Country Status (2)
Country | Link |
---|---|
EA (1) | EA201991877A3 (en) |
WO (1) | WO2015073072A1 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI3125898T1 (en) | 2014-03-31 | 2020-07-31 | The Scripps Research Institute | Pharmacophore for trail induction |
WO2016079527A1 (en) | 2014-11-19 | 2016-05-26 | Tetralogic Birinapant Uk Ltd | Combination therapy |
WO2016097773A1 (en) | 2014-12-19 | 2016-06-23 | Children's Cancer Institute | Therapeutic iap antagonists for treating proliferative disorders |
KR20240005186A (en) * | 2015-01-30 | 2024-01-11 | 온코슈틱스 인코포레이티드 | 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo [1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, analogs and salts thereof and their use in therapy |
SG10202108306UA (en) | 2016-01-29 | 2021-08-30 | Oncoceutics Inc | G protein-coupled receptor (gpcr) modulation by imipridones |
SG10202007520WA (en) | 2016-03-02 | 2020-09-29 | Eisai R&D Man Co Ltd | Eribulin-based antibody-drug conjugates and methods of use |
JP7300394B2 (en) | 2017-01-17 | 2023-06-29 | ヘパリジェニックス ゲーエムベーハー | Protein kinase inhibition to promote liver regeneration or reduce or prevent hepatocyte death |
US10172862B2 (en) | 2017-01-30 | 2019-01-08 | Oncoceutics, Inc. | Imipridones for gliomas |
CN111153891B (en) * | 2020-01-10 | 2023-03-31 | 贵州医科大学 | Substituted benzimidazole PI3K alpha/mTOR double-target inhibitor and pharmaceutical composition and application thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4642345A (en) * | 1980-08-14 | 1987-02-10 | Mead Johnson & Company | 6,7-dihydro-3H-imidazo[1,2-a]-purine-9(4H)-ones |
CA2832342C (en) * | 2011-04-29 | 2019-12-31 | The Penn State Research Foundation | Small molecule trail gene induction by normal and tumor cells as an anticancer therapy |
-
2014
- 2014-07-25 WO PCT/US2014/048241 patent/WO2015073072A1/en active Application Filing
- 2014-09-12 EA EA201991877A patent/EA201991877A3/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2015073072A1 (en) | 2015-05-21 |
EA201991877A3 (en) | 2020-05-31 |
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