EA201991730A1 -
N - {[2- (PIPERIDIN-1-IL) Phenyl] (Phenyl) Methyl} -2- (3-OXO-3,4-DIHYDRO-2H-1,4-Benzoxazazin-7-IL) ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ROR-GAMMA MODULATORS FOR TREATMENT OF AUTOIMMUNE DISEASES
- Google Patents
N - {[2- (PIPERIDIN-1-IL) Phenyl] (Phenyl) Methyl} -2- (3-OXO-3,4-DIHYDRO-2H-1,4-Benzoxazazin-7-IL) ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ROR-GAMMA MODULATORS FOR TREATMENT OF AUTOIMMUNE DISEASES
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Priority claimed from PCT/EP2018/052172external-prioritypatent/WO2018138362A1/en
Publication of EA201991730A1publicationCriticalpatent/EA201991730A1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Изобретение предоставляет, например, N-{[2-(пиперидин-1-ил)фенил](фенил)метил}-2-(3-оксо-3,4-дигидро-2H-1,4-бензоксазин-7-ил)ацетамидные производные и родственные соединения в качестве модуляторов ROR-гамма для лечения аутоиммунных заболеваний, аутоиммунно-ассоциированных заболеваний, воспалительных заболеваний, нарушений обмена веществ, фиброзных заболеваний или холестатических заболеваний, таких как артрит и астма.The invention provides, for example, N - {[2- (piperidin-1-yl) phenyl] (phenyl) methyl} -2- (3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl ) acetamide derivatives and related compounds as ROR-gamma modulators for the treatment of autoimmune diseases, autoimmune-associated diseases, inflammatory diseases, metabolic disorders, fibrotic diseases or cholestatic diseases such as arthritis and asthma.
EA201991730A2017-06-292018-01-29
N - {[2- (PIPERIDIN-1-IL) Phenyl] (Phenyl) Methyl} -2- (3-OXO-3,4-DIHYDRO-2H-1,4-Benzoxazazin-7-IL) ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ROR-GAMMA MODULATORS FOR TREATMENT OF AUTOIMMUNE DISEASES
EA201991730A1
(en)
N-{[2-(piperidin-1-yl)phenyl](phenyl)methyl}-2-(3-oxo-3,4-dihydro-2h-1,4-benzoxa zin-7-yl)acetamide derivatives and related compounds as ror-gamma modulators for treating autoimmune diseases
N - {[2- (PIPERIDIN-1-IL) Phenyl] (Phenyl) Methyl} -2- (3-OXO-3,4-DIHYDRO-2H-1,4-Benzoxazazin-7-IL) ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ROR-GAMMA MODULATORS FOR TREATMENT OF AUTOIMMUNE DISEASES
N-[2-(piperidin-1-yl)phenyl](phenyl)methyl-2-(3-oxo-3,4-dihydro-2h-1,4-benzoxa zin-7-yl)acetamide derivatives and related compounds as ror-gamma modulators for treating autoimmune diseases