EA201991340A1 - METHODS FOR INDUCING IMMUNOLOGICAL TOLERANCE FOR BLOOD COAGING FACTORS - Google Patents

METHODS FOR INDUCING IMMUNOLOGICAL TOLERANCE FOR BLOOD COAGING FACTORS

Info

Publication number
EA201991340A1
EA201991340A1 EA201991340A EA201991340A EA201991340A1 EA 201991340 A1 EA201991340 A1 EA 201991340A1 EA 201991340 A EA201991340 A EA 201991340A EA 201991340 A EA201991340 A EA 201991340A EA 201991340 A1 EA201991340 A1 EA 201991340A1
Authority
EA
Eurasian Patent Office
Prior art keywords
blood
coaging
factors
methods
immunological tolerance
Prior art date
Application number
EA201991340A
Other languages
Russian (ru)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/064323 external-priority patent/WO2018102760A1/en
Publication of EA201991340A1 publication Critical patent/EA201991340A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Abstract

В настоящем изобретении предусмотрены способы индуцирования иммунологической толерантности у человека, включающие введение человеку эффективного количества композиции или химерного белка, содержащих фактор свертывания крови и Fc-область.The present invention provides methods for inducing immunological tolerance in humans, comprising administering to a human an effective amount of a composition or chimeric protein containing a blood coagulation factor and an Fc region.

EA201991340A 2017-11-07 2017-12-01 METHODS FOR INDUCING IMMUNOLOGICAL TOLERANCE FOR BLOOD COAGING FACTORS EA201991340A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762582829P 2017-11-07 2017-11-07
PCT/US2017/064323 WO2018102760A1 (en) 2016-12-02 2017-12-01 Methods of inducing immune tolerance to clotting factors

Publications (1)

Publication Number Publication Date
EA201991340A1 true EA201991340A1 (en) 2019-11-29

Family

ID=68653614

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201991340A EA201991340A1 (en) 2017-11-07 2017-12-01 METHODS FOR INDUCING IMMUNOLOGICAL TOLERANCE FOR BLOOD COAGING FACTORS

Country Status (1)

Country Link
EA (1) EA201991340A1 (en)

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