EA201991315A1 - CYCLIC DINUCLEOTIDES AS STING AGONISTS (INTERFERON GENE STIMULATOR) - Google Patents

CYCLIC DINUCLEOTIDES AS STING AGONISTS (INTERFERON GENE STIMULATOR)

Info

Publication number
EA201991315A1
EA201991315A1 EA201991315A EA201991315A EA201991315A1 EA 201991315 A1 EA201991315 A1 EA 201991315A1 EA 201991315 A EA201991315 A EA 201991315A EA 201991315 A EA201991315 A EA 201991315A EA 201991315 A1 EA201991315 A1 EA 201991315A1
Authority
EA
Eurasian Patent Office
Prior art keywords
interferon gene
sting agonists
cyclic dinucleotides
gene stimulator
sting
Prior art date
Application number
EA201991315A
Other languages
Russian (ru)
Other versions
EA038805B1 (en
Inventor
Масато Йосикава
Морихиса Сайтох
Таисуке Като
Яйои Йоситома
Томохиро Секи
Ясуо Накагава
Юсуке Томинари
Масаки Сето
Юсуке Сасаки
Масанори Оканива
Цунео Ода
Акито Сибуя
Косуке Хидака
Дзениу Сиокава
Сюмпеи Мурата
Ацутоси Окабе
Есихиса Накада
Митийо Мотизуки
Брайан Скотт Фриз
Таисуке Тавараиси
Ясуфуми Вада
Пол Д. Гринспэн
Original Assignee
Такеда Фармасьютикал Компани Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Такеда Фармасьютикал Компани Лимитед filed Critical Такеда Фармасьютикал Компани Лимитед
Priority claimed from PCT/IB2017/057588 external-priority patent/WO2018100558A2/en
Publication of EA201991315A1 publication Critical patent/EA201991315A1/en
Publication of EA038805B1 publication Critical patent/EA038805B1/en

Links

Abstract

В данном описании предложено соединение, обладающее агонистической активностью STING, которое, как можно ожидать, будет пригодным в качестве средства для профилактики или лечения заболеваний, связанных со STING. Данное изобретение относится к соединению, представленному формулой (I)где каждый символ является таким, как определено в описании, или его солью.In this description, a compound is provided having a STING agonist activity, which can be expected to be useful as an agent for the prophylaxis or treatment of diseases associated with STING. This invention relates to a compound represented by formula (I) wherein each symbol is as defined herein, or a salt thereof.

EA201991315A 2017-11-21 2017-12-01 Cyclic dinucleotides as sting (stimulator of interferon genes) agonists EA038805B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762589300P 2017-11-21 2017-11-21
PCT/IB2017/057588 WO2018100558A2 (en) 2016-12-01 2017-12-01 Cyclic dinucleotide

Publications (2)

Publication Number Publication Date
EA201991315A1 true EA201991315A1 (en) 2019-12-30
EA038805B1 EA038805B1 (en) 2021-10-21

Family

ID=69061877

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201991315A EA038805B1 (en) 2017-11-21 2017-12-01 Cyclic dinucleotides as sting (stimulator of interferon genes) agonists

Country Status (1)

Country Link
EA (1) EA038805B1 (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014179335A1 (en) * 2013-04-29 2014-11-06 Memorial Sloan Kettering Cancer Center Compositions and methods for altering second messenger signaling
ES2754269T3 (en) * 2013-05-18 2020-04-16 Aduro Biotech Inc Compositions and Activation Methods of "Interferon Gene Stimulator-dependent" Signaling
EP3546473A1 (en) * 2014-12-16 2019-10-02 Kayla Therapeutics Cyclic [(2',5')p(3',5')p]-dinucleotides for cytokine induction
WO2017027645A1 (en) * 2015-08-13 2017-02-16 Merck Sharp & Dohme Corp. Cyclic di-nucleotide compounds as sting agonists
WO2017161349A1 (en) * 2016-03-18 2017-09-21 Immune Sensor, Llc Cyclic di-nucleotide compounds and methods of use

Also Published As

Publication number Publication date
EA038805B1 (en) 2021-10-21

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