EA201991306A1 - COMPOUNDS AND WAYS OF THEIR APPLICATION - Google Patents

COMPOUNDS AND WAYS OF THEIR APPLICATION

Info

Publication number
EA201991306A1
EA201991306A1 EA201991306A EA201991306A EA201991306A1 EA 201991306 A1 EA201991306 A1 EA 201991306A1 EA 201991306 A EA201991306 A EA 201991306A EA 201991306 A EA201991306 A EA 201991306A EA 201991306 A1 EA201991306 A1 EA 201991306A1
Authority
EA
Eurasian Patent Office
Prior art keywords
disease
ion channel
pathological condition
compounds
condition related
Prior art date
Application number
EA201991306A
Other languages
Russian (ru)
Inventor
Киран РЕДДИ
Габриэль МАРТИНЕС БОТЕЛЬЯ
Эндрю Марк Гриффин
Брайан Эдвард Маррон
Original Assignee
Праксис Пресижн Медсинз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Праксис Пресижн Медсинз, Инк. filed Critical Праксис Пресижн Медсинз, Инк.
Priority claimed from PCT/US2017/063533 external-priority patent/WO2018098499A1/en
Publication of EA201991306A1 publication Critical patent/EA201991306A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Данное изобретение относится, в частности, к конденсированным гетероарильным соединениям и композициям, пригодным для предотвращения и/или лечения заболевания или патологического состояния, относящегося к аберрантной функции потенциал-зависимого натриевого ионного канала, например к аномальному позднему/постоянному натриевому току. В данном документе также предложены способы лечения заболевания или патологического состояния, относящегося к аберрантной функции натриевого ионного канала, включая синдром Драве или эпилепсию.This invention relates, in particular, to condensed heteroaryl compounds and compositions suitable for the prevention and / or treatment of a disease or pathological condition related to the aberrant function of the voltage-gated sodium ion channel, for example, abnormal lateral / constant sodium current. The present document also provides methods for treating a disease or pathological condition related to the aberrant function of the sodium ion channel, including Drave syndrome or epilepsy.

EA201991306A 2017-08-30 2017-11-28 COMPOUNDS AND WAYS OF THEIR APPLICATION EA201991306A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762552073P 2017-08-30 2017-08-30
PCT/US2017/063533 WO2018098499A1 (en) 2016-11-28 2017-11-28 Compounds and their methods of use

Publications (1)

Publication Number Publication Date
EA201991306A1 true EA201991306A1 (en) 2020-03-20

Family

ID=69942792

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201991306A EA201991306A1 (en) 2017-08-30 2017-11-28 COMPOUNDS AND WAYS OF THEIR APPLICATION

Country Status (1)

Country Link
EA (1) EA201991306A1 (en)

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