EA201991181A1 - PSMA-TARGETED TRANSPECIFIC PROTEINS AND WAYS OF THEIR APPLICATION - Google Patents
PSMA-TARGETED TRANSPECIFIC PROTEINS AND WAYS OF THEIR APPLICATIONInfo
- Publication number
- EA201991181A1 EA201991181A1 EA201991181A EA201991181A EA201991181A1 EA 201991181 A1 EA201991181 A1 EA 201991181A1 EA 201991181 A EA201991181 A EA 201991181A EA 201991181 A EA201991181 A EA 201991181A EA 201991181 A1 EA201991181 A1 EA 201991181A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- psma
- targeted
- proteins
- transpecific
- ways
- Prior art date
Links
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
В настоящем документе представлены нацеленные на простатический специфический мембранный антиген (PSMA) триспецифические белки, содержащие домен, связывающийся с CD3, домен, обеспечивающий увеличение времени полужизни, и домен, связывающийся с PSMA. Также представлены фармацевтические композиции на их основе, а также нуклеиновые кислоты, рекомбинантные векторы экспрессии и клетки-хозяева для получения таких PSMA-нацеленных триспецифических белков. Также раскрыты способы применения раскрытых PSMA-нацеленных триспецифических белков в предупреждении и/или лечении заболеваний, состояний и нарушений.This document presents trispecific proteins targeted to a prostate specific membrane antigen (PSMA) containing a CD3 binding domain, a half-life extension domain, and a PSMA binding domain. Also provided are pharmaceutical compositions based on them, as well as nucleic acids, recombinant expression vectors and host cells to produce such PSMA-targeted trispecific proteins. Also disclosed are methods of using the disclosed PSMA-targeted trispecific proteins in the prevention and / or treatment of diseases, conditions and disorders.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662426077P | 2016-11-23 | 2016-11-23 | |
PCT/US2017/063126 WO2018098356A1 (en) | 2016-11-23 | 2017-11-22 | Psma targeting trispecific proteins and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201991181A1 true EA201991181A1 (en) | 2019-12-30 |
Family
ID=69061896
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201991181A EA201991181A1 (en) | 2016-11-23 | 2017-11-22 | PSMA-TARGETED TRANSPECIFIC PROTEINS AND WAYS OF THEIR APPLICATION |
Country Status (1)
Country | Link |
---|---|
EA (1) | EA201991181A1 (en) |
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2017
- 2017-11-22 EA EA201991181A patent/EA201991181A1/en unknown
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