EA201991027A9 - ANTIBODIES AGAINST CD38 AND FUSED PROTEINS WITH A LOWERENED ALPHA-2b INTERFERON - Google Patents
ANTIBODIES AGAINST CD38 AND FUSED PROTEINS WITH A LOWERENED ALPHA-2b INTERFERONInfo
- Publication number
- EA201991027A9 EA201991027A9 EA201991027A EA201991027A EA201991027A9 EA 201991027 A9 EA201991027 A9 EA 201991027A9 EA 201991027 A EA201991027 A EA 201991027A EA 201991027 A EA201991027 A EA 201991027A EA 201991027 A9 EA201991027 A9 EA 201991027A9
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alpha
- lowerened
- interferon
- antibodies against
- fused proteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Представлены антитела, специфически связывающиеся с CD38, так же как конструкции, содержащие такие антитела, слитые с белками ослабленного интерферона альфа-2b. Слитые конструкции анти-CD38-ослабленный интерферон альфа-2b можно использовать для ингибирования пролиферации злокачественных клеток, которые экспрессируют как CD38, так и рецептор для IFN-альфа-2b, так же как для индукции апоптоза в таких клетках. Ингибирование пролиферации и индукция апоптоза злокачественных клеток может служить в качестве фундамента для лечения лежащей в основе злокачественной опухоли.Antibodies specifically binding to CD38 are provided, as are constructs containing such antibodies fused to proteins of attenuated interferon alpha-2b. The anti-CD38-attenuated interferon alpha-2b fusion constructs can be used to inhibit the proliferation of cancer cells that express both CD38 and the receptor for IFN-alpha-2b, as well as to induce apoptosis in such cells. Inhibition of proliferation and apoptosis of malignant cells can serve as a foundation for the treatment of the underlying malignant tumor.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EA201991027A EA201991027A9 (en) | 2013-04-29 | 2013-04-29 | ANTIBODIES AGAINST CD38 AND FUSED PROTEINS WITH A LOWERENED ALPHA-2b INTERFERON |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EA201991027A EA201991027A9 (en) | 2013-04-29 | 2013-04-29 | ANTIBODIES AGAINST CD38 AND FUSED PROTEINS WITH A LOWERENED ALPHA-2b INTERFERON |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201991027A1 EA201991027A1 (en) | 2019-09-30 |
EA201991027A9 true EA201991027A9 (en) | 2019-11-27 |
Family
ID=68048696
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201991027A EA201991027A9 (en) | 2013-04-29 | 2013-04-29 | ANTIBODIES AGAINST CD38 AND FUSED PROTEINS WITH A LOWERENED ALPHA-2b INTERFERON |
Country Status (1)
Country | Link |
---|---|
EA (1) | EA201991027A9 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20220034807A (en) * | 2019-07-16 | 2022-03-18 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | Antibodies having specificity for CD38 and uses thereof |
-
2013
- 2013-04-29 EA EA201991027A patent/EA201991027A9/en unknown
Also Published As
Publication number | Publication date |
---|---|
EA201991027A1 (en) | 2019-09-30 |
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