Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Вайкинг Терапьютикс, Инк.filedCriticalВайкинг Терапьютикс, Инк.
Priority claimed from PCT/US2017/062393external-prioritypatent/WO2018094265A2/en
Publication of EA201991004A1publicationCriticalpatent/EA201991004A1/en
Настоящее изобретение обеспечивает способы и композиции для лечения симптомов со стороны печени болезней накопления гликогена путем введения агонистов тиреоидных гормонов. Способы и композиции, предложенные в настоящем документе, полезны в лечении гиперлипидемии, гиперхолестеринемии, стеатоза печени, кардиомегалии, гепатомегалии, фиброза печени и цирроза, ассоциированных с болезнями накопления гликогена (БНГ) и дефектами метаболизма гликогена. Указанные соединения также могут быть полезны в предотвращении связанных с БНГ гепатоцеллюлярной аденомы и гепатоцеллюлярной карциномы.The present invention provides methods and compositions for treating symptoms of liver diseases of glycogen accumulation by administration of thyroid hormone agonists. The methods and compositions provided herein are useful in the treatment of hyperlipidemia, hypercholesterolemia, liver steatosis, cardiomegaly, hepatomegaly, liver fibrosis and cirrhosis associated with glycogen accumulation diseases (BNG) and glycogen metabolism defects. These compounds may also be useful in preventing BNG-related hepatocellular adenoma and hepatocellular carcinoma.
EA201991004A2017-02-082017-11-17
METHOD FOR TREATING GLYCOGEN ACCUMULATION DISEASE
EA201991004A1
(en)
antibodies that bind to sortilin and inhibit progranulin binding, pharmaceutical compositions, preparations thereof, use of antibodies, kit and method for preventing or treating a disease associated with decreased levels of pgrn
Compositions and methods of use of gamma-ketoaldehyde scavengers for treating, preventing or improving nonalcoholic fatty liver disease (nafld), nash, ald or conditions related to the liver.