EA201990883A1 - BERBERIN SALTS, UROSODESOXYCHOLIC ACID SALTS AND THEIR COMBINATIONS, METHODS FOR PRODUCING AND USE - Google Patents
BERBERIN SALTS, UROSODESOXYCHOLIC ACID SALTS AND THEIR COMBINATIONS, METHODS FOR PRODUCING AND USEInfo
- Publication number
- EA201990883A1 EA201990883A1 EA201990883A EA201990883A EA201990883A1 EA 201990883 A1 EA201990883 A1 EA 201990883A1 EA 201990883 A EA201990883 A EA 201990883A EA 201990883 A EA201990883 A EA 201990883A EA 201990883 A1 EA201990883 A1 EA 201990883A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- diseases
- liver
- disorders
- methods
- diabetes
- Prior art date
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Abstract
Предложены композиции берберина в комбинации с фармацевтически активными органическими кислотами и способы их применения для лечения различных заболеваний или расстройств; соединения, полученные на основе берберина и фармацевтически активных органических кислот и на основе урсодезоксихолевой кислоты и фармацевтически активных органических оснований, и фармацевтические композиции и способы их получения и терапевтического применения для лечения и/или предотвращения различных заболеваний или расстройств. Соединения и фармацевтические композиции согласно настоящему изобретению можно применять для лечения различных заболеваний или расстройств, таких как диабет, осложнения диабета, дислипидемия, гиперлипидемия, ожирение, метаболические синдромы, нарушения метаболизма, предшествующие диабету, атеросклероз, сердечные заболевания, нейродегенеративные заболевания, саркопения, мышечная атрофия, воспаление, рак и заболевания и состояния печени, такие как жировой гепатоз, неалкогольная жировая болезнь печени, неалкогольный стеатогепатит, холестатические заболевания печени или заболевание печени "трансплантат против хозяина". Соединения также можно применять для улучшения функций печени при хронических вирусных заболеваниях печени и алкогольных заболеваниях печени.Berberine compositions in combination with pharmaceutically active organic acids and methods for their use in the treatment of various diseases or disorders are provided; compounds derived from berberine and pharmaceutically active organic acids and based on ursodeoxycholic acid and pharmaceutically active organic bases, and pharmaceutical compositions and methods for their preparation and therapeutic use for the treatment and / or prevention of various diseases or disorders. The compounds and pharmaceutical compositions of the present invention can be used to treat various diseases or disorders, such as diabetes, complications of diabetes, dyslipidemia, hyperlipidemia, obesity, metabolic syndromes, metabolic disorders, previous diabetes, atherosclerosis, heart disease, neurodegenerative diseases, sarcopenia, muscle atrophy , inflammation, cancer and diseases and conditions of the liver, such as fatty hepatosis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, cholestatic liver disease or graft versus host disease. The compounds can also be used to improve liver function in chronic viral liver diseases and alcoholic liver diseases.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562128077P | 2015-03-04 | 2015-03-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201990883A1 true EA201990883A1 (en) | 2019-12-30 |
Family
ID=69061872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201990883A EA201990883A1 (en) | 2015-03-04 | 2015-07-28 | BERBERIN SALTS, UROSODESOXYCHOLIC ACID SALTS AND THEIR COMBINATIONS, METHODS FOR PRODUCING AND USE |
Country Status (1)
| Country | Link |
|---|---|
| EA (1) | EA201990883A1 (en) |
-
2015
- 2015-07-28 EA EA201990883A patent/EA201990883A1/en unknown
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