EA201990556A1 - CELLULAR METABOLIC INHIBITORS - Google Patents

CELLULAR METABOLIC INHIBITORS

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Publication number
EA201990556A1
EA201990556A1 EA201990556A EA201990556A EA201990556A1 EA 201990556 A1 EA201990556 A1 EA 201990556A1 EA 201990556 A EA201990556 A EA 201990556A EA 201990556 A EA201990556 A EA 201990556A EA 201990556 A1 EA201990556 A1 EA 201990556A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cellular metabolic
metabolic inhibitors
inhibitors
present
adonosyltransferase
Prior art date
Application number
EA201990556A
Other languages
Russian (ru)
Inventor
Зенон Д. Контеатис
Чжихуа Суй
Джереми М. Травинс
Чжисён Е
Original Assignee
Агиос Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Агиос Фармасьютикалз, Инк. filed Critical Агиос Фармасьютикалз, Инк.
Priority claimed from PCT/US2017/049439 external-priority patent/WO2018045071A1/en
Publication of EA201990556A1 publication Critical patent/EA201990556A1/en

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Abstract

В настоящем изобретении предложены соединения, представляющие собой ингибиторы метионинаденозилтрансферазы-2A (MAT2A), которые могут применяться в качестве терапевтических агентов для лечения злокачественных новообразований, при этом указанные соединения соответствуют общей формуле (IA)где R, R, R, Rи Rопределены в настоящем описании.The present invention provides compounds which are methionine-adonosyltransferase-2A inhibitors (MAT2A), which can be used as therapeutic agents for the treatment of malignant neoplasms, said compounds corresponding to the general formula (IA) where R, R, R, R and R are defined in the present description .

EA201990556A 2017-08-22 2017-08-30 CELLULAR METABOLIC INHIBITORS EA201990556A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762548738P 2017-08-22 2017-08-22
PCT/US2017/049439 WO2018045071A1 (en) 2016-08-31 2017-08-30 Inhibitors of cellular metabolic processes

Publications (1)

Publication Number Publication Date
EA201990556A1 true EA201990556A1 (en) 2019-09-30

Family

ID=68000218

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201990556A EA201990556A1 (en) 2017-08-22 2017-08-30 CELLULAR METABOLIC INHIBITORS

Country Status (1)

Country Link
EA (1) EA201990556A1 (en)

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