EA201990488A1 - NEW T-CELL RECEPTORS AND IMMUNOTHERAPY WITH THEIR APPLICATION - Google Patents

NEW T-CELL RECEPTORS AND IMMUNOTHERAPY WITH THEIR APPLICATION

Info

Publication number
EA201990488A1
EA201990488A1 EA201990488A EA201990488A EA201990488A1 EA 201990488 A1 EA201990488 A1 EA 201990488A1 EA 201990488 A EA201990488 A EA 201990488A EA 201990488 A EA201990488 A EA 201990488A EA 201990488 A1 EA201990488 A1 EA 201990488A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antigen
col6a3
immunotherapy
new
application
Prior art date
Application number
EA201990488A
Other languages
Russian (ru)
Inventor
Леони Альтен
Доминик Маурер
Штеффен Вальтер
Себастиан Бунк
Original Assignee
Имматикс Байотекнолоджиз Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Имматикс Байотекнолоджиз Гмбх filed Critical Имматикс Байотекнолоджиз Гмбх
Priority claimed from PCT/EP2017/066630 external-priority patent/WO2018033291A1/en
Publication of EA201990488A1 publication Critical patent/EA201990488A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

Настоящее изобретение относится к антигенраспознающим структурам к антигенам COL6A3. В частности, в изобретении предложены новые молекулы на основе T-клеточного рецептора (ТКР), являющиеся селективными и специфическими для экспрессируемого опухолями антигена COL6A3. ТКР по изобретению и фрагменты, связывающиеся с антигеном COL6A3, образованные из этого ТКР, полезны для диагностики, лечения и профилактики раковых заболеваний, при которых экспрессируется COL6A3. Предложены также нуклеиновые кислоты, кодирующие антигенраспознающие структуры по изобретению, векторы, включающие данные нуклеиновые кислоты, рекомбинантные клетки, экспрессирующие эти антигенраспознающие структуры, и фармацевтические композиции, включающие соединения по изобретению.The present invention relates to antigen-recognition structures for COL6A3 antigens. In particular, the invention provides new molecules based on the T-cell receptor (TCR), which are selective and specific for tumor expressed antigen COL6A3. TKR according to the invention and fragments that bind to the COL6A3 antigen formed from this TKR are useful for the diagnosis, treatment and prevention of cancer in which COL6A3 is expressed. Nucleic acids encoding antigen-recognizing structures according to the invention, vectors including these nucleic acids, recombinant cells expressing these antigen-recognizing structures, and pharmaceutical compositions comprising compounds of the invention are also provided.

EA201990488A 2016-08-18 2017-07-04 NEW T-CELL RECEPTORS AND IMMUNOTHERAPY WITH THEIR APPLICATION EA201990488A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662376632P 2016-08-18 2016-08-18
PCT/EP2017/066630 WO2018033291A1 (en) 2016-08-17 2017-07-04 T cell receptors and immune therapy using the same

Publications (1)

Publication Number Publication Date
EA201990488A1 true EA201990488A1 (en) 2019-07-31

Family

ID=67399633

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201990488A EA201990488A1 (en) 2016-08-18 2017-07-04 NEW T-CELL RECEPTORS AND IMMUNOTHERAPY WITH THEIR APPLICATION

Country Status (1)

Country Link
EA (1) EA201990488A1 (en)

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