EA201990404A1 - IMPROVED FORMS OF THE SELECTIVE PI3K DELTA INHIBITOR FOR APPLICATION IN PHARMACEUTICALS - Google Patents

IMPROVED FORMS OF THE SELECTIVE PI3K DELTA INHIBITOR FOR APPLICATION IN PHARMACEUTICALS

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Publication number
EA201990404A1
EA201990404A1 EA201990404A EA201990404A EA201990404A1 EA 201990404 A1 EA201990404 A1 EA 201990404A1 EA 201990404 A EA201990404 A EA 201990404A EA 201990404 A EA201990404 A EA 201990404A EA 201990404 A1 EA201990404 A1 EA 201990404A1
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EA
Eurasian Patent Office
Prior art keywords
pharmaceuticals
application
pi3k delta
improved forms
delta inhibitor
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Application number
EA201990404A
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Russian (ru)
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Publication of EA201990404A1 publication Critical patent/EA201990404A1/en

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Abstract

Настоящее изобретение относится к твердофазным формам соли п-толуолсульфоновой кислоты (ПТСК) селективного ингибитора PI3K-дельта (S)-2-(1-(4-амино-3-(3-фтор-4-изопропоксифенил)-1H-пиразоло[3,4-d]пиримидин-1-ил)этил)-3-(3-фторфенил)-4H-хромен-4-она (TGR-1202). Настоящее изобретение также относится к способам получения указанных соединений, содержащим их фармацевтическим композициям и способам лечения опосредованных киназой PI3K (фосфатидилинозитол-3-киназой) болезней или расстройств, таких как рак, путем их введения.The present invention relates to solid-phase forms of a salt of p-toluenesulfonic acid (PTSK) of a selective inhibitor of PI3K-delta (S) -2- (1- (4-amino-3- (3-fluoro-4-isopropoxyphenyl) -1H-pyrazolo [3 , 4-d] pyrimidin-1-yl) ethyl) -3- (3-fluorophenyl) -4H-chromen-4-one (TGR-1202). The present invention also relates to methods for producing said compounds, pharmaceutical compositions containing them and methods for treating PI3K kinase (phosphatidylinositol-3-kinase) mediated diseases or disorders, such as cancer, by administering them.

EA201990404A 2014-05-27 2015-05-26 IMPROVED FORMS OF THE SELECTIVE PI3K DELTA INHIBITOR FOR APPLICATION IN PHARMACEUTICALS EA201990404A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN2597CH2014 2014-05-27

Publications (1)

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EA201990404A1 true EA201990404A1 (en) 2019-10-31

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Application Number Title Priority Date Filing Date
EA201990404A EA201990404A1 (en) 2014-05-27 2015-05-26 IMPROVED FORMS OF THE SELECTIVE PI3K DELTA INHIBITOR FOR APPLICATION IN PHARMACEUTICALS

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EA (1) EA201990404A1 (en)

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