EA201990188A1 - 5,7-DIHYDROPYRROLOPIRIDININE DERIVATIVES - Google Patents

5,7-DIHYDROPYRROLOPIRIDININE DERIVATIVES

Info

Publication number
EA201990188A1
EA201990188A1 EA201990188A EA201990188A EA201990188A1 EA 201990188 A1 EA201990188 A1 EA 201990188A1 EA 201990188 A EA201990188 A EA 201990188A EA 201990188 A EA201990188 A EA 201990188A EA 201990188 A1 EA201990188 A1 EA 201990188A1
Authority
EA
Eurasian Patent Office
Prior art keywords
dihydropyrrolopiridinine
derivatives
oxide
compound
disorders
Prior art date
Application number
EA201990188A
Other languages
Russian (ru)
Inventor
Ли ЧЖАН
Кристофер Райан Батлер
Элизабет Мэри Бэк
Майкл Аарон Бродний
Мэтью Франк Браун
Лаура Энн Макалистер
Эрик Эльфи Лашапелле
Адам Мэтью Гилберт
Original Assignee
Пфайзер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Инк. filed Critical Пфайзер Инк.
Priority claimed from PCT/IB2017/053565 external-priority patent/WO2018002760A1/en
Publication of EA201990188A1 publication Critical patent/EA201990188A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Представленное изобретение предусматривает отчасти соединение формулы Iили его N-оксид, или фармацевтически приемлемую соль соединения или N-оксида, где R, R, L, A и E являются такими, как описано в описании изобретения; способы получения; промежуточные соединения, использованные в получении; и композицию, содержащую такие соединения, N-оксиды или соли, и их применение для лечения M4-опосредованных (или связанных с M4) расстройств, включая, например, болезнь Альцгеймера, шизофрению (например, ее когнитивные и негативные симптомы), боль, зависимость и расстройства сна.The present invention provides in part a compound of formula I or an N-oxide thereof, or a pharmaceutically acceptable salt of a compound or N-oxide, wherein R, R, L, A and E are as described in the description of the invention; production methods; intermediates used in the preparation; and a composition containing such compounds, N-oxides or salts, and their use for the treatment of M4-mediated (or M4-related) disorders, including, for example, Alzheimer's disease, schizophrenia (for example, its cognitive and negative symptoms), pain, dependence and sleep disorders.

EA201990188A 2016-08-09 2017-06-15 5,7-DIHYDROPYRROLOPIRIDININE DERIVATIVES EA201990188A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662372421P 2016-08-09 2016-08-09
PCT/IB2017/053565 WO2018002760A1 (en) 2016-07-01 2017-06-15 5,7-dihydro-pyrrolo-pyridine derivatives for treating neurological and neurodegenerative diseases

Publications (1)

Publication Number Publication Date
EA201990188A1 true EA201990188A1 (en) 2019-07-31

Family

ID=67399622

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201990188A EA201990188A1 (en) 2016-08-09 2017-06-15 5,7-DIHYDROPYRROLOPIRIDININE DERIVATIVES

Country Status (1)

Country Link
EA (1) EA201990188A1 (en)

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