EA201990076A1 - CRYSTAL SOLID BET INHIBITOR FORMS - Google Patents
CRYSTAL SOLID BET INHIBITOR FORMSInfo
- Publication number
- EA201990076A1 EA201990076A1 EA201990076A EA201990076A EA201990076A1 EA 201990076 A1 EA201990076 A1 EA 201990076A1 EA 201990076 A EA201990076 A EA 201990076A EA 201990076 A EA201990076 A EA 201990076A EA 201990076 A1 EA201990076 A1 EA 201990076A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- bet inhibitor
- crystal solid
- inhibitor forms
- solid bet
- preparation
- Prior art date
Links
- 239000007787 solid Substances 0.000 title abstract 2
- 229940125763 bromodomain inhibitor Drugs 0.000 title 1
- 239000013078 crystal Substances 0.000 title 1
- 108091005625 BRD4 Proteins 0.000 abstract 1
- 108091052242 Bromo- and Extra-Terminal domain (BET) family Proteins 0.000 abstract 1
- 102100033641 Bromodomain-containing protein 2 Human genes 0.000 abstract 1
- 102100033642 Bromodomain-containing protein 3 Human genes 0.000 abstract 1
- 102100029895 Bromodomain-containing protein 4 Human genes 0.000 abstract 1
- 101000871850 Homo sapiens Bromodomain-containing protein 2 Proteins 0.000 abstract 1
- 101000871851 Homo sapiens Bromodomain-containing protein 3 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Настоящее изобретение относится к кристаллическим твердым формам ингибитора белков BET, таких как BRD2, BRD3, BRD4 и BRD-t, а также к способам их получения и промежуточным соединениям для их получения, при этом указанное соединение пригодно для лечения заболеваний, таких как рак.The present invention relates to crystalline solid forms of an inhibitor of BET proteins, such as BRD2, BRD3, BRD4 and BRD-t, as well as to methods for their preparation and intermediates for their preparation, and this compound is suitable for the treatment of diseases such as cancer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662397575P | 2016-09-21 | 2016-09-21 | |
| PCT/US2017/038121 WO2017222977A1 (en) | 2016-06-20 | 2017-06-19 | Crystalline solid forms of a bet inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201990076A1 true EA201990076A1 (en) | 2019-07-31 |
Family
ID=67399640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201990076A EA201990076A1 (en) | 2016-09-21 | 2017-06-19 | CRYSTAL SOLID BET INHIBITOR FORMS |
Country Status (1)
| Country | Link |
|---|---|
| EA (1) | EA201990076A1 (en) |
-
2017
- 2017-06-19 EA EA201990076A patent/EA201990076A1/en unknown
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