EA201892656A1 - CHROMATOGRAPHY OF HYDROPHOBIC INTERACTION FOR CLEANING OLIGONUCLEOTIDES - Google Patents

CHROMATOGRAPHY OF HYDROPHOBIC INTERACTION FOR CLEANING OLIGONUCLEOTIDES

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Publication number
EA201892656A1
EA201892656A1 EA201892656A EA201892656A EA201892656A1 EA 201892656 A1 EA201892656 A1 EA 201892656A1 EA 201892656 A EA201892656 A EA 201892656A EA 201892656 A EA201892656 A EA 201892656A EA 201892656 A1 EA201892656 A1 EA 201892656A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hydrophobic interaction
chromatography
oligonucleotides
cleaning
target oligonucleotide
Prior art date
Application number
EA201892656A
Other languages
Russian (ru)
Inventor
Роберт С. Гронке
Ратнеш С. Джоши
Original Assignee
Байоджен Ма Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Байоджен Ма Инк. filed Critical Байоджен Ма Инк.
Priority claimed from PCT/US2017/037126 external-priority patent/WO2017218454A1/en
Publication of EA201892656A1 publication Critical patent/EA201892656A1/en

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Abstract

Настоящее изобретение относится к биохимии, а именно к способу отделения целевого олигонуклеотида от смеси, содержащей целевой олигонуклеотид и сопутствующую продукту примесь (варианты). Способ по изобретению предусматривает использование хроматографии гидрофобного взаимодействия (ХГВ) и приводит к улучшенному отделению примесей N-1 и P=O от целевого олигонуклеотида, а также исключению применения органических растворителей во время процесса очистки. В некоторых вариантах осуществления изобретения способ по изобретению также может удалять примеси ABasic, CNEt и/или N+1.The present invention relates to biochemistry, and in particular to a method for separating a target oligonucleotide from a mixture containing a target oligonucleotide and an impurity accompanying the product (variants). The method according to the invention involves the use of hydrophobic interaction chromatography (CHB) and leads to improved separation of N-1 and P = O impurities from the target oligonucleotide, as well as the elimination of the use of organic solvents during the purification process. In some embodiments, the method of the invention can also remove ABasic, CNEt and / or N + 1 impurities.

EA201892656A 2017-05-01 2017-06-13 CHROMATOGRAPHY OF HYDROPHOBIC INTERACTION FOR CLEANING OLIGONUCLEOTIDES EA201892656A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762492402P 2017-05-01 2017-05-01
PCT/US2017/037126 WO2017218454A1 (en) 2016-06-14 2017-06-13 Hydrophobic interaction chromatography for purification of oligonucleotides

Publications (1)

Publication Number Publication Date
EA201892656A1 true EA201892656A1 (en) 2019-08-30

Family

ID=67734902

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201892656A EA201892656A1 (en) 2017-05-01 2017-06-13 CHROMATOGRAPHY OF HYDROPHOBIC INTERACTION FOR CLEANING OLIGONUCLEOTIDES

Country Status (1)

Country Link
EA (1) EA201892656A1 (en)

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