EA201892656A1 - CHROMATOGRAPHY OF HYDROPHOBIC INTERACTION FOR CLEANING OLIGONUCLEOTIDES - Google Patents
CHROMATOGRAPHY OF HYDROPHOBIC INTERACTION FOR CLEANING OLIGONUCLEOTIDESInfo
- Publication number
- EA201892656A1 EA201892656A1 EA201892656A EA201892656A EA201892656A1 EA 201892656 A1 EA201892656 A1 EA 201892656A1 EA 201892656 A EA201892656 A EA 201892656A EA 201892656 A EA201892656 A EA 201892656A EA 201892656 A1 EA201892656 A1 EA 201892656A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- hydrophobic interaction
- chromatography
- oligonucleotides
- cleaning
- target oligonucleotide
- Prior art date
Links
Landscapes
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
Настоящее изобретение относится к биохимии, а именно к способу отделения целевого олигонуклеотида от смеси, содержащей целевой олигонуклеотид и сопутствующую продукту примесь (варианты). Способ по изобретению предусматривает использование хроматографии гидрофобного взаимодействия (ХГВ) и приводит к улучшенному отделению примесей N-1 и P=O от целевого олигонуклеотида, а также исключению применения органических растворителей во время процесса очистки. В некоторых вариантах осуществления изобретения способ по изобретению также может удалять примеси ABasic, CNEt и/или N+1.The present invention relates to biochemistry, and in particular to a method for separating a target oligonucleotide from a mixture containing a target oligonucleotide and an impurity accompanying the product (variants). The method according to the invention involves the use of hydrophobic interaction chromatography (CHB) and leads to improved separation of N-1 and P = O impurities from the target oligonucleotide, as well as the elimination of the use of organic solvents during the purification process. In some embodiments, the method of the invention can also remove ABasic, CNEt and / or N + 1 impurities.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762492402P | 2017-05-01 | 2017-05-01 | |
PCT/US2017/037126 WO2017218454A1 (en) | 2016-06-14 | 2017-06-13 | Hydrophobic interaction chromatography for purification of oligonucleotides |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201892656A1 true EA201892656A1 (en) | 2019-08-30 |
Family
ID=67734902
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201892656A EA201892656A1 (en) | 2017-05-01 | 2017-06-13 | CHROMATOGRAPHY OF HYDROPHOBIC INTERACTION FOR CLEANING OLIGONUCLEOTIDES |
Country Status (1)
Country | Link |
---|---|
EA (1) | EA201892656A1 (en) |
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2017
- 2017-06-13 EA EA201892656A patent/EA201892656A1/en unknown
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