EA201892549A1 - APPLICATION OF 1H-PYRAZOLO [4,3-b] Pyridine As Inhibitors Of PDE1 - Google Patents

APPLICATION OF 1H-PYRAZOLO [4,3-b] Pyridine As Inhibitors Of PDE1

Info

Publication number
EA201892549A1
EA201892549A1 EA201892549A EA201892549A EA201892549A1 EA 201892549 A1 EA201892549 A1 EA 201892549A1 EA 201892549 A EA201892549 A EA 201892549A EA 201892549 A EA201892549 A EA 201892549A EA 201892549 A1 EA201892549 A1 EA 201892549A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrazolo
pyridine
pde1
inhibitors
application
Prior art date
Application number
EA201892549A
Other languages
Russian (ru)
Other versions
EA037544B1 (en
Inventor
Ян Келер
Карстен Джухл
Мауро Мариго
Пауло Хорхе Виейра Витал
Миккел Джессинг
Мортен Ланггард
Ларс Кин Расмуссен
Карл Мартин Себастиан Клементсон
Original Assignee
Х. Лундбекк А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Х. Лундбекк А/С filed Critical Х. Лундбекк А/С
Priority claimed from PCT/EP2017/066255 external-priority patent/WO2018007249A1/en
Publication of EA201892549A1 publication Critical patent/EA201892549A1/en
Publication of EA037544B1 publication Critical patent/EA037544B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/04—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D305/06—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

В настоящем изобретении предусмотрены 1H-пиразоло[4,3-b]пиридин-7-амины формулы (I) в качестве ингибиторов PDE1, и их применение в качестве лекарственного препарата, в частности, для лечения нейродегенеративных расстройств и психических расстройств.The present invention provides 1H-pyrazolo [4,3-b] pyridine-7-amines of formula (I) as PDE1 inhibitors, and their use as a medicine, in particular for the treatment of neurodegenerative disorders and mental disorders.

EA201892549A 2017-04-04 2017-06-30 USE OF 1H-PYRAZOLO[4,3-b]PYRIDINES AS PDE1 INHIBITORS EA037544B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201700236 2017-04-04
PCT/EP2017/066255 WO2018007249A1 (en) 2016-07-04 2017-06-30 1h-pyrazolo[4,3-b]pyridines as pde1 inhibitors

Publications (2)

Publication Number Publication Date
EA201892549A1 true EA201892549A1 (en) 2019-05-31
EA037544B1 EA037544B1 (en) 2021-04-12

Family

ID=66644957

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201892549A EA037544B1 (en) 2017-04-04 2017-06-30 USE OF 1H-PYRAZOLO[4,3-b]PYRIDINES AS PDE1 INHIBITORS

Country Status (1)

Country Link
EA (1) EA037544B1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1802621B1 (en) * 2004-10-19 2009-05-06 SmithKline Beecham (Cork) Limited Crf receptor antagonists and methods relating thereto
MX2009009793A (en) * 2007-03-14 2009-10-16 Ranbaxy Lab Ltd Pyrazolo (3, 4-b) pyridine derivatives as phosphodiesterase inhibitors.

Also Published As

Publication number Publication date
EA037544B1 (en) 2021-04-12

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM KG TJ TM