EA201892538A1 - POSITIVE ALLOSTERIC MODULATORS OF MUSCARIN ACETYL CHOLINE RECEPTOR M - Google Patents

POSITIVE ALLOSTERIC MODULATORS OF MUSCARIN ACETYL CHOLINE RECEPTOR M

Info

Publication number
EA201892538A1
EA201892538A1 EA201892538A EA201892538A EA201892538A1 EA 201892538 A1 EA201892538 A1 EA 201892538A1 EA 201892538 A EA201892538 A EA 201892538A EA 201892538 A EA201892538 A EA 201892538A EA 201892538 A1 EA201892538 A1 EA 201892538A1
Authority
EA
Eurasian Patent Office
Prior art keywords
amine
compounds
positive allosteric
allosteric modulators
muscarin
Prior art date
Application number
EA201892538A
Other languages
Russian (ru)
Other versions
EA038420B1 (en
Inventor
Крейг В. Линдсли
П. Джеффри Конн
Даррен В. Энгерс
Шон Боллингер
Джеймс С. Тарр
Пол Спиаринг
Джули Л. Энгерс
Маделин Лонг
Томас М. Бриджес
Original Assignee
Вандербильт Юниверсити
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Вандербильт Юниверсити filed Critical Вандербильт Юниверсити
Priority claimed from PCT/US2017/038711 external-priority patent/WO2017223290A1/en
Publication of EA201892538A1 publication Critical patent/EA201892538A1/en
Publication of EA038420B1 publication Critical patent/EA038420B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

В данном документе раскрыты трициклические соединения, включающие соединения, представляющие собой пиримидо[4',5':4,5]тиено[2,3-c]пиридазин-8-амин, пиридо[3',2M,5]тиено[3,2-d]пиримидин-4-амин, пиразино[2',3':4,5]тиено[3,2-d]пиримидин-4-амин, пиридо[3',2':4,5]фуро[3,2-d]пиримидин-4-амин и пиримидо[4',5':4,5]фуро[2,3-c]пиридазин-8-амин, которые могут быть применимыми в качестве положительных аллостерических модуляторов мускаринового ацетилхолинового рецептора M(mAChR M). В данном документе также раскрыты способы получения соединений, фармацевтические композиции, содержащие данные соединения, и способы лечения неврологических и психических расстройств, ассоциированных с нарушением функции мускаринового ацетилхолинового рецептора, с применением данных соединений и композиций.This document discloses tricyclic compounds, including compounds that are pyrimido [4 ', 5': 4,5] thieno [2,3-c] pyridazin-8-amine, pyrido [3 ', 2M, 5] thieno [3 , 2-d] pyrimidin-4-amine, pyrazino [2 ', 3': 4,5] thieno [3,2-d] pyrimidine-4-amine, pyrido [3 ', 2': 4,5] furo [3,2-d] pyrimidine-4-amine and pyrimido [4 ', 5': 4,5] furo [2,3-c] pyridazin-8-amine, which can be applicable as positive allosteric modulators of muscarinic acetylcholine M receptor (mAChR M). This document also discloses methods for preparing compounds, pharmaceutical compositions containing these compounds, and methods for treating neurological and mental disorders associated with dysfunction of the muscarinic acetylcholine receptor using these compounds and compositions.

EA201892538A 2017-03-14 2017-06-22 Positive allosteric modulators of the muscarinic acetylcholine receptor m4 EA038420B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762471281P 2017-03-14 2017-03-14
PCT/US2017/038711 WO2017223290A1 (en) 2016-06-22 2017-06-22 Positive allosteric modulators of the muscarinic acetylcholine receptor m4

Publications (2)

Publication Number Publication Date
EA201892538A1 true EA201892538A1 (en) 2019-05-31
EA038420B1 EA038420B1 (en) 2021-08-26

Family

ID=66644965

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201892538A EA038420B1 (en) 2017-03-14 2017-06-22 Positive allosteric modulators of the muscarinic acetylcholine receptor m4

Country Status (1)

Country Link
EA (1) EA038420B1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015027214A1 (en) * 2013-08-23 2015-02-26 Vanderbilt University Substituted thieno[2,3-c]pyridazine-6-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor m4
WO2015027204A1 (en) * 2013-08-23 2015-02-26 Vanderbilt University Substituted thieno[2,3-b]pyridine-2-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor m4

Also Published As

Publication number Publication date
EA038420B1 (en) 2021-08-26

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