EA201891161A1 - BIFUNCTIONAL MOLECULES CONTAINING POLYETHYLENE GLYCOL TO SUPPRESS CATARACT AND PRESBIOPIA - Google Patents
BIFUNCTIONAL MOLECULES CONTAINING POLYETHYLENE GLYCOL TO SUPPRESS CATARACT AND PRESBIOPIAInfo
- Publication number
- EA201891161A1 EA201891161A1 EA201891161A EA201891161A EA201891161A1 EA 201891161 A1 EA201891161 A1 EA 201891161A1 EA 201891161 A EA201891161 A EA 201891161A EA 201891161 A EA201891161 A EA 201891161A EA 201891161 A1 EA201891161 A1 EA 201891161A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- cataract
- presbiopia
- suppress
- polyethylene glycol
- molecules containing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
Abstract
В данном документе описаны способы подавления или обращения прогрессирования формирования катаракты или пресбиопии глаза путем введения бифункциональной молекулы, содержащей замещенный или незамещенный амин, или сукцинимид, или карбоновую кислоту, или изоцианат, или изотиоцианат, или сульфонилхлорид, или альдегид, или карбодиимид, или ацилазид, или ангидрид, или фторбензол, или карбонат, или сложный N-гидроксисукцинимидный эфир, или сложный имидоэфир, или эпоксид или сложный фторфениловый эфир, ковалентно связанные с молекулярным ответвлением. И пресбиопия, и катаракты вызваны агрегацией растворимых белков хрусталика, называемых кристаллинами.This document describes methods of suppressing or reversing the progression of cataract formation or presbyopia of the eye by introducing a bifunctional molecule containing a substituted or unsubstituted amine, or succinimide, or carboxylic acid, or isocyanate, or isothiocyanate, or sulfonyl chloride, or aldehyde, or carbodiimide, or acyl azide, or anhydride, or fluorobenzene, or carbonate, or N-hydroxysuccinimide ester, or imido ester, or epoxide or fluorophenyl ester, covalently bound to molecular phenomenon. Both presbyopia and cataracts are caused by the aggregation of soluble lens proteins called crystallins.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562254863P | 2015-11-13 | 2015-11-13 | |
PCT/US2016/061490 WO2017083619A1 (en) | 2015-11-13 | 2016-11-11 | Bifunctional molecules containing peg for use in inhibiting cataracts and presbyopia |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201891161A1 true EA201891161A1 (en) | 2018-10-31 |
EA035402B1 EA035402B1 (en) | 2020-06-08 |
Family
ID=57421950
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201891161A EA035402B1 (en) | 2015-11-13 | 2016-11-11 | Bifunctional molecules containing peg for use in inhibiting cataracts and presbyopia |
Country Status (18)
Country | Link |
---|---|
US (1) | US10736863B2 (en) |
EP (1) | EP3373921B1 (en) |
JP (1) | JP6794444B2 (en) |
KR (1) | KR20180083378A (en) |
CN (1) | CN108348494A (en) |
AU (1) | AU2016354479B2 (en) |
CA (1) | CA3004585A1 (en) |
CL (1) | CL2018001282A1 (en) |
CR (1) | CR20180294A (en) |
EA (1) | EA035402B1 (en) |
ES (1) | ES2745291T3 (en) |
IL (1) | IL259027B (en) |
MX (1) | MX2018005903A (en) |
PE (1) | PE20181070A1 (en) |
SA (1) | SA518391553B1 (en) |
SG (1) | SG11201803606XA (en) |
WO (1) | WO2017083619A1 (en) |
ZA (1) | ZA201802978B (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20151747A1 (en) | 2013-03-14 | 2015-12-18 | Univ Massachusetts | METHOD TO INHIBIT CATARACTS AND PRESBYCIA |
SG11201803606XA (en) | 2015-11-13 | 2018-05-30 | Univ Massachusetts | Bifunctional molecules containing peg for use in inhibiting cataracts and presbyopia |
US10220012B2 (en) | 2016-06-03 | 2019-03-05 | Joerg H. KRUMEICH | Solution for ophthalmology |
TWI798452B (en) * | 2019-06-17 | 2023-04-11 | 晶碩光學股份有限公司 | Contact lens product |
CN111840225B (en) * | 2020-08-12 | 2021-09-14 | 陈丽娜 | Eye drop for treating glaucoma and preparation method thereof |
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-
2016
- 2016-11-11 SG SG11201803606XA patent/SG11201803606XA/en unknown
- 2016-11-11 CN CN201680066303.0A patent/CN108348494A/en active Pending
- 2016-11-11 EA EA201891161A patent/EA035402B1/en unknown
- 2016-11-11 ES ES16802203T patent/ES2745291T3/en active Active
- 2016-11-11 MX MX2018005903A patent/MX2018005903A/en active IP Right Grant
- 2016-11-11 CR CR20180294A patent/CR20180294A/en unknown
- 2016-11-11 US US15/349,334 patent/US10736863B2/en active Active
- 2016-11-11 EP EP16802203.6A patent/EP3373921B1/en active Active
- 2016-11-11 PE PE2018000767A patent/PE20181070A1/en unknown
- 2016-11-11 JP JP2018524251A patent/JP6794444B2/en active Active
- 2016-11-11 WO PCT/US2016/061490 patent/WO2017083619A1/en active Application Filing
- 2016-11-11 KR KR1020187016675A patent/KR20180083378A/en not_active Application Discontinuation
- 2016-11-11 CA CA3004585A patent/CA3004585A1/en active Pending
- 2016-11-11 AU AU2016354479A patent/AU2016354479B2/en active Active
-
2018
- 2018-04-29 IL IL259027A patent/IL259027B/en active IP Right Grant
- 2018-05-07 ZA ZA2018/02978A patent/ZA201802978B/en unknown
- 2018-05-10 SA SA518391553A patent/SA518391553B1/en unknown
- 2018-05-11 CL CL2018001282A patent/CL2018001282A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
BR112018009582A2 (en) | 2018-11-06 |
SA518391553B1 (en) | 2021-03-01 |
CL2018001282A1 (en) | 2018-11-16 |
WO2017083619A1 (en) | 2017-05-18 |
EP3373921A1 (en) | 2018-09-19 |
JP6794444B2 (en) | 2020-12-02 |
IL259027B (en) | 2021-05-31 |
JP2018536659A (en) | 2018-12-13 |
AU2016354479B2 (en) | 2021-10-07 |
CR20180294A (en) | 2018-08-10 |
MX2018005903A (en) | 2019-04-04 |
EA035402B1 (en) | 2020-06-08 |
CA3004585A1 (en) | 2017-05-18 |
ZA201802978B (en) | 2019-07-31 |
US10736863B2 (en) | 2020-08-11 |
SG11201803606XA (en) | 2018-05-30 |
AU2016354479A1 (en) | 2018-05-24 |
KR20180083378A (en) | 2018-07-20 |
CN108348494A (en) | 2018-07-31 |
EP3373921B1 (en) | 2019-08-28 |
ES2745291T3 (en) | 2020-02-28 |
US20170135972A1 (en) | 2017-05-18 |
IL259027A (en) | 2018-06-28 |
PE20181070A1 (en) | 2018-07-04 |
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