EA201800504A1 - ZINCAS MANIFESTING MUKOLITIC ACTIVITY - Google Patents

ZINCAS MANIFESTING MUKOLITIC ACTIVITY

Info

Publication number
EA201800504A1
EA201800504A1 EA201800504A EA201800504A EA201800504A1 EA 201800504 A1 EA201800504 A1 EA 201800504A1 EA 201800504 A EA201800504 A EA 201800504A EA 201800504 A EA201800504 A EA 201800504A EA 201800504 A1 EA201800504 A1 EA 201800504A1
Authority
EA
Eurasian Patent Office
Prior art keywords
zincas
zinc
new
diacetylcysteinate
chnos
Prior art date
Application number
EA201800504A
Other languages
Russian (ru)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of EA201800504A1 publication Critical patent/EA201800504A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/315—Zinc compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/06—Zinc compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретение относится к новому биологически активному химическому веществу, в частности к синтезу ранее неизвестного соединения диацетилцистеинат цинка(II) со следующей общей формулой: [Zn(CHNOS)], называемого также цинкас, который может быть использован в ветеринарии в качестве муколитического препарата, для лечения болезни животных. Целью изобретения является изыскание нового более эффективного средства для лечения заболевания органов дыхания. Поставленная цель достигается тем, что применяется новое координационное соединение цинкас диацетилцистеинат цинка(II) [Zn(CHNOS)], который синтезируется взаимодействием сульфата цинка с ацетилцистеином (АЦЦ) и обладает муколитической активностью. Установлено, что цинкас не вызывает даже незначительных явлений гиперемии, отека, расчесов на месте аппликации. У животных также не выявлено признаков токсикоза при накожной аппликации испытуемыми соединениями. У цинкаса не выявлено кожно-раздражающего и кожно-резорбтивного действия.The invention relates to a new biologically active chemical substance, in particular to the synthesis of a previously unknown compound of zinc (II) diacetylcysteinate with the following general formula: [Zn (CHNOS)], also called zincas, which can be used in veterinary medicine as a mucolytic drug for the treatment of animal diseases. The aim of the invention is to find a new, more effective means for the treatment of respiratory diseases. This goal is achieved by the use of a new coordination compound, zinc, zinc (II) diacetylcysteinate [Zn (CHNOS)], which is synthesized by the interaction of zinc sulfate with acetylcysteine (ACC) and has mucolytic activity. It has been established that zincas does not even cause minor effects of hyperemia, edema, scratching at the site of application. The animals also showed no signs of toxicosis with cutaneous application of the test compounds. Zincas showed no skin-irritating and skin-resorptive action.

EA201800504A 2018-05-22 2018-09-06 ZINCAS MANIFESTING MUKOLITIC ACTIVITY EA201800504A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
TJ1801199 2018-05-22

Publications (1)

Publication Number Publication Date
EA201800504A1 true EA201800504A1 (en) 2019-11-29

Family

ID=68653563

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201800504A EA201800504A1 (en) 2018-05-22 2018-09-06 ZINCAS MANIFESTING MUKOLITIC ACTIVITY

Country Status (1)

Country Link
EA (1) EA201800504A1 (en)

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