EA201800229A1 - METHOD FOR PRODUCING PEMETREXEDA DISATRIUM 2,5-HYDRATE AND PHARMACEUTICAL COMPOSITION CONTAINING PEMETREXEDA DISATRIUM 2,5-HYDRATE - Google Patents
METHOD FOR PRODUCING PEMETREXEDA DISATRIUM 2,5-HYDRATE AND PHARMACEUTICAL COMPOSITION CONTAINING PEMETREXEDA DISATRIUM 2,5-HYDRATEInfo
- Publication number
- EA201800229A1 EA201800229A1 EA201800229A EA201800229A EA201800229A1 EA 201800229 A1 EA201800229 A1 EA 201800229A1 EA 201800229 A EA201800229 A EA 201800229A EA 201800229 A EA201800229 A EA 201800229A EA 201800229 A1 EA201800229 A1 EA 201800229A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- hydrate
- pemetrexeda
- disatrium
- pharmaceutical composition
- producing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/02—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of powders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Mechanical Engineering (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Изобретение относится к способу получения фармацевтической композиции, содержащей пеметрексед динатрий 2,5-гидрат в качестве активного ингредиента, в виде лиофилизированного порошка для приготовления раствора для инъекций. Предлагаемый способ обеспечивает получение фармацевтической композиции с высокой стабильностью и низкой загрузкой примесей.The invention relates to a method for producing a pharmaceutical composition containing pemetrexed disodium 2,5-hydrate as an active ingredient, in the form of a lyophilized powder for the preparation of an injection solution. The proposed method provides a pharmaceutical composition with high stability and low loading of impurities.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EA201800229A EA038700B1 (en) | 2018-04-26 | 2018-04-26 | Method of producing a pharmaceutical composition of disodium pemetrexed |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EA201800229A EA038700B1 (en) | 2018-04-26 | 2018-04-26 | Method of producing a pharmaceutical composition of disodium pemetrexed |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201800229A1 true EA201800229A1 (en) | 2019-10-31 |
EA038700B1 EA038700B1 (en) | 2021-10-07 |
Family
ID=68319001
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201800229A EA038700B1 (en) | 2018-04-26 | 2018-04-26 | Method of producing a pharmaceutical composition of disodium pemetrexed |
Country Status (1)
Country | Link |
---|---|
EA (1) | EA038700B1 (en) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102106833B (en) * | 2011-02-12 | 2012-05-02 | 海南锦瑞制药股份有限公司 | Pemetrexed disodium freeze-dried powder injection and preparation method thereof |
CN103239415A (en) * | 2012-05-18 | 2013-08-14 | 湖北一半天制药有限公司 | Preparation method of pemetrexed disodium freeze-dried formulation for injection |
CN103494777B (en) * | 2013-08-23 | 2014-12-24 | 江苏奥赛康药业股份有限公司 | Pemetrexed disodium freeze-dried composition and preparation method thereof |
-
2018
- 2018-04-26 EA EA201800229A patent/EA038700B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
EA038700B1 (en) | 2021-10-07 |
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EA201800229A1 (en) | METHOD FOR PRODUCING PEMETREXEDA DISATRIUM 2,5-HYDRATE AND PHARMACEUTICAL COMPOSITION CONTAINING PEMETREXEDA DISATRIUM 2,5-HYDRATE |