EA201800054A1 - METHOD OF GENERATION OF MEDICINES IN THE FORM OF AEROSOL - Google Patents

METHOD OF GENERATION OF MEDICINES IN THE FORM OF AEROSOL

Info

Publication number
EA201800054A1
EA201800054A1 EA201800054A EA201800054A EA201800054A1 EA 201800054 A1 EA201800054 A1 EA 201800054A1 EA 201800054 A EA201800054 A EA 201800054A EA 201800054 A EA201800054 A EA 201800054A EA 201800054 A1 EA201800054 A1 EA 201800054A1
Authority
EA
Eurasian Patent Office
Prior art keywords
aerosol
drug
air
flow
patient
Prior art date
Application number
EA201800054A
Other languages
Russian (ru)
Inventor
Анатолий Максимович БАКЛАНОВ
Сергей Владимирович ВАЛИУЛИН
Андрей Александрович ОНИЩУК
Олег Раджабович АБДИЕВ
Original Assignee
Общество с ограниченной ответственностью "Научно-производственный Инновационный внедренческий центр"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Общество с ограниченной ответственностью "Научно-производственный Инновационный внедренческий центр" filed Critical Общество с ограниченной ответственностью "Научно-производственный Инновационный внедренческий центр"
Priority to EA201800054A priority Critical patent/EA201800054A1/en
Priority to PCT/EA2018/000010 priority patent/WO2019129341A1/en
Publication of EA201800054A1 publication Critical patent/EA201800054A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/16—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas incorporating means for heating or cooling the material to be sprayed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретение относится к способам получения лекарственного аэрозоля. Задача - разработка более эффективного способа доставки лекарственных средств в виде аэрозоля - решается благодаря генерации лекарственного средства в виде аэрозоля и включает равномерную подачу через микропомпу атмосферного воздуха в нагревательный канал, пропускание подогретого воздуха через камеру с размещенным лекарственным средством, термическую возгонку исходной субстанции лекарственного средства с последующей нуклеацией полученного пересыщенного пара и конденсационным ростом образованных аэрозольных частиц, дополнительную подачу атмосферного воздуха в образовавшийся аэрозоль и подачу через выходной патрубок в легкие пациенту в виде аэрозоля. Положительный эффект предложенного способа достигается за счет использования микропомпы для подачи воздуха с постоянной скоростью в испарительную камеру с лекарственным средством. Во время вдоха пациента дополнительный поток воздуха примешивается к аэрозольному потоку через специальные отверстия в камере аэрозолеобразования, не возмущая поток воздуха через испарительную камеру. Преимущества: поддерживается постоянный размер аэрозольных частиц и постоянная массовая скорость подачи аэрозоля в легкие пациента, что в итоге позволяет точно контролировать дозировку аэрозольной формы лекарственного средства.The invention relates to methods for producing medicinal aerosol. The task is to develop a more efficient method of drug delivery in the form of an aerosol — solved by generating the drug as an aerosol and includes uniformly supplying atmospheric air through the micropomp into the heating channel, passing heated air through the chamber with the placed drug, thermal sublimation of the original substance of the drug the subsequent nucleation of the resulting supersaturated vapor and the condensation growth of aerosol particles formed, additional The flow of atmospheric air into the resulting aerosol and the flow through the outlet in the lungs to the patient in the form of an aerosol. The positive effect of the proposed method is achieved through the use of micropumps for supplying air at a constant speed to the evaporation chamber with the drug. During the inhalation of the patient, additional air flow is mixed into the aerosol stream through special openings in the aerosol formation chamber, not disturbing the air flow through the evaporation chamber. Advantages: maintaining a constant size of aerosol particles and a constant mass flow rate of aerosol into the patient’s lungs, which ultimately allows you to precisely control the dosage of the aerosol form of the drug.

EA201800054A 2017-12-26 2017-12-26 METHOD OF GENERATION OF MEDICINES IN THE FORM OF AEROSOL EA201800054A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EA201800054A EA201800054A1 (en) 2017-12-26 2017-12-26 METHOD OF GENERATION OF MEDICINES IN THE FORM OF AEROSOL
PCT/EA2018/000010 WO2019129341A1 (en) 2017-12-26 2018-12-24 Method of generating medication in aerosol form

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EA201800054A EA201800054A1 (en) 2017-12-26 2017-12-26 METHOD OF GENERATION OF MEDICINES IN THE FORM OF AEROSOL

Publications (1)

Publication Number Publication Date
EA201800054A1 true EA201800054A1 (en) 2019-06-28

Family

ID=66998705

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201800054A EA201800054A1 (en) 2017-12-26 2017-12-26 METHOD OF GENERATION OF MEDICINES IN THE FORM OF AEROSOL

Country Status (2)

Country Link
EA (1) EA201800054A1 (en)
WO (1) WO2019129341A1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6694975B2 (en) * 1996-11-21 2004-02-24 Aradigm Corporation Temperature controlling device for aerosol drug delivery
US8479728B2 (en) * 2008-02-18 2013-07-09 Virginia Commonwealth University Effective delivery of nanoparticles and micrometer-sized pharmaceutical aerosols to the lung through enhanced condensational growth
JP5963375B2 (en) * 2012-01-03 2016-08-03 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム Aerosol generator and system with improved airflow

Also Published As

Publication number Publication date
WO2019129341A1 (en) 2019-07-04

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