EA201790786A1 - Комбинированная терапия вызываемой вирусами hbv и hdv инфекции - Google Patents

Комбинированная терапия вызываемой вирусами hbv и hdv инфекции

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Publication number
EA201790786A1
EA201790786A1 EA201790786A EA201790786A EA201790786A1 EA 201790786 A1 EA201790786 A1 EA 201790786A1 EA 201790786 A EA201790786 A EA 201790786A EA 201790786 A EA201790786 A EA 201790786A EA 201790786 A1 EA201790786 A1 EA 201790786A1
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EA
Eurasian Patent Office
Prior art keywords
hbv
hdv
virus infections
combined therapy
therapy caused
Prior art date
Application number
EA201790786A
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English (en)
Inventor
Александер Александров
Original Assignee
Мир Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мир Гмбх filed Critical Мир Гмбх
Publication of EA201790786A1 publication Critical patent/EA201790786A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
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    • C12N2760/00011—Details
    • C12N2760/10011—Arenaviridae
    • C12N2760/10111—Deltavirus, e.g. hepatitis delta virus
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  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Communicable Diseases (AREA)
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  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
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Abstract

В заявке описана композиция, содержащая ингибитор котранспортирующего Na-таурохолат полипептида (NTCP) и другое действующее вещество, выбранное из группы, которая состоит из нуклеозидного аналога, такого как ламивудин, телбивудин или энтекавир, нуклеотидного аналога, такого как тенофовир, адефовир, и иммуномодулятора, такого как интерферон альфа. Ингибитор NTCP ингибирует проникновение HBV/HDV в клетку, и предпочтительно его создают на основе пептида пре-S1 HBV. В заявке описаны также способы лечения вызываемой HBV и HDV инфекции, гепатита В и D или хронического гепатита В и D.
EA201790786A 2014-10-07 2015-10-07 Комбинированная терапия вызываемой вирусами hbv и hdv инфекции EA201790786A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14187865 2014-10-07
PCT/EP2015/073173 WO2016055534A2 (en) 2014-10-07 2015-10-07 Combination therapy of hbv and hdv infection

Publications (1)

Publication Number Publication Date
EA201790786A1 true EA201790786A1 (ru) 2017-09-29

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Country Status (11)

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US (2) US20180228804A1 (ru)
EP (2) EP4098273A1 (ru)
KR (2) KR102599942B1 (ru)
CN (2) CN107106686B (ru)
CA (3) CA3175236A1 (ru)
EA (1) EA201790786A1 (ru)
ES (1) ES2922883T3 (ru)
PL (1) PL3204030T3 (ru)
PT (1) PT3204030T (ru)
SI (1) SI3204030T1 (ru)
WO (1) WO2016055534A2 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017274094B2 (en) 2016-05-30 2020-09-10 Shanghai Hep Pharmaceutical Co., Ltd. Compositions and methods for treating metabolic diseases
EP3392267A1 (en) 2017-04-18 2018-10-24 Myr GmbH Therapy of atherosclerosis, primary biliary cirrhosis and nrlp3 inflammasome-associated disease by htcp inhibitors
CN109718364A (zh) * 2017-10-27 2019-05-07 上海贺普药业股份有限公司 充分剂量条件下治疗乙肝病毒相关肝病的药物和方法
US20210061859A1 (en) * 2018-01-11 2021-03-04 The University Of Tokyo NTCP Inhibitor
EP4157327A1 (en) * 2020-05-28 2023-04-05 The Regents Of The University Of Michigan Compositions and methods for preventing and treating sars-cov-2 infection
TWI815194B (zh) 2020-10-22 2023-09-11 美商基利科學股份有限公司 介白素2-Fc融合蛋白及使用方法
CN116510021A (zh) * 2022-01-24 2023-08-01 上海贺普药业股份有限公司 有限化慢性乙肝的核苷（酸）类药物治疗的药物及方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002094866A1 (en) * 2001-05-25 2002-11-28 Dobeel Corp Pre-s protein of hepatitis b virus (hbv) as an adjuvant and a component of hbv vaccine
WO2009092396A1 (en) * 2008-01-25 2009-07-30 Universitätsklinikum Heidelberg Hydrophobic modified pres-derived peptides of hepatitis b virus (hbv) and their use as hbv and hdv entry inhibitors
EP2245047B1 (en) * 2008-01-25 2020-11-18 Ruprecht-Karls-Universität Heidelberg Hydrophobic modified pres-derived peptides of hepatitis b virus (hbv) and their use as vehicles for the specific delivery of compounds to the liver
CN104662036B (zh) * 2012-04-25 2018-11-09 华辉安健（北京）生物科技有限公司 乙肝肝炎病毒功能性受体的组成以及相关应用
PL2917231T3 (pl) * 2012-11-12 2019-08-30 Ruprecht-Karls-Universität Heidelberg Lipopeptydy do stosowania w leczeniu chorób wątroby i chorób sercowo-naczyniowych

Also Published As

Publication number Publication date
KR20170066339A (ko) 2017-06-14
CA3175236A1 (en) 2016-04-14
EP3204030A2 (en) 2017-08-16
EP4098273A1 (en) 2022-12-07
US20180228804A1 (en) 2018-08-16
WO2016055534A3 (en) 2016-06-09
CN107106686A (zh) 2017-08-29
KR20230156963A (ko) 2023-11-15
CA3175242A1 (en) 2016-04-14
PT3204030T (pt) 2022-08-05
ES2922883T3 (es) 2022-09-21
EP3204030B1 (en) 2022-04-27
SI3204030T1 (sl) 2022-10-28
US20220040178A1 (en) 2022-02-10
CN107106686B (zh) 2022-09-27
CA2959465A1 (en) 2016-04-14
KR102599942B1 (ko) 2023-11-09
CA2959465C (en) 2024-05-21
WO2016055534A2 (en) 2016-04-14
CN115920061A (zh) 2023-04-07
PL3204030T3 (pl) 2022-09-19

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