EA201790055A2 - COMPOSITIONS OF DEOXIC ACID AND ITS SALTS - Google Patents

COMPOSITIONS OF DEOXIC ACID AND ITS SALTS

Info

Publication number
EA201790055A2
EA201790055A2 EA201790055A EA201790055A EA201790055A2 EA 201790055 A2 EA201790055 A2 EA 201790055A2 EA 201790055 A EA201790055 A EA 201790055A EA 201790055 A EA201790055 A EA 201790055A EA 201790055 A2 EA201790055 A2 EA 201790055A2
Authority
EA
Eurasian Patent Office
Prior art keywords
salts
deoxic
compositions
acid
level
Prior art date
Application number
EA201790055A
Other languages
Russian (ru)
Other versions
EA034320B1 (en
EA201790055A3 (en
Inventor
Роберт Эмил Ходж
Джеффри Дуглас Вебстер
Роберт М. Мориарти
Original Assignee
Китера Биофармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Китера Биофармасьютикалз, Инк. filed Critical Китера Биофармасьютикалз, Инк.
Priority to EA201790055A priority Critical patent/EA034320B1/en
Publication of EA201790055A2 publication Critical patent/EA201790055A2/en
Publication of EA201790055A3 publication Critical patent/EA201790055A3/en
Publication of EA034320B1 publication Critical patent/EA034320B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Настоящая заявка относится к водной фармацевтической композиции, содержащей от приблизительно 0,4% (мас./об.) до менее чем приблизительно 2% (мас./об.) соли дезоксихолевой кислоты, причем рН указанной композиции сохраняется на уровне от приблизительно 8,1 до приблизительно 8,5, что обеспечивает указанной композиции устойчивость к выпадению в осадок. Также в настоящей заявке предложены способы стабилизации водной фармацевтической композиции, содержащей от приблизительно 0,4% (мас./об.) до менее чем приблизительно 2% (мас./об.) соли дезоксихолевой кислоты, для предотвращения образования осадка, при этом указанный способ включает поддержание рН указанного раствора на уровне от приблизительно 8,1 до приблизительно 8,5.The present application relates to an aqueous pharmaceutical composition containing from about 0.4% (w / v) to less than about 2% (w / v) deoxycholic acid salts, wherein the pH of said composition is maintained at a level from about 8, 1 to about 8.5, which provides this composition with resistance to precipitation. Also in this application, methods are provided for stabilizing an aqueous pharmaceutical composition containing from about 0.4% (w / v) to less than about 2% (w / v) of deoxycholic acid salt to prevent the formation of a precipitate, with the method includes maintaining the pH of the solution at a level of from about 8.1 to about 8.5.

EA201790055A 2011-08-23 2011-08-23 Compositions of sodium deoxycholate EA034320B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EA201790055A EA034320B1 (en) 2011-08-23 2011-08-23 Compositions of sodium deoxycholate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EA201790055A EA034320B1 (en) 2011-08-23 2011-08-23 Compositions of sodium deoxycholate

Publications (3)

Publication Number Publication Date
EA201790055A2 true EA201790055A2 (en) 2017-05-31
EA201790055A3 EA201790055A3 (en) 2017-09-29
EA034320B1 EA034320B1 (en) 2020-01-28

Family

ID=58794011

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201790055A EA034320B1 (en) 2011-08-23 2011-08-23 Compositions of sodium deoxycholate

Country Status (1)

Country Link
EA (1) EA034320B1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6417179B1 (en) * 1998-10-13 2002-07-09 Craig G. Burkhart Ear wax solution
HUE038247T2 (en) * 2004-05-19 2018-10-29 Los Angeles Biomedical Res Inst Harbor Ucla Medical Ct Injectable coposition comprising sodium deoxycholate

Also Published As

Publication number Publication date
EA034320B1 (en) 2020-01-28
EA201790055A3 (en) 2017-09-29

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