EA201700519A2 - ANTIMICROBIAL COMBINATION WITH RESPECT TO SUSTAINABLE CARBAPENES OF GRAMORATORAL BACTERIA OF KLEBSIELLA PNEUMONIAE KIND, PRODUCING METAL-β-LACTAMAZ - Google Patents

ANTIMICROBIAL COMBINATION WITH RESPECT TO SUSTAINABLE CARBAPENES OF GRAMORATORAL BACTERIA OF KLEBSIELLA PNEUMONIAE KIND, PRODUCING METAL-β-LACTAMAZ

Info

Publication number
EA201700519A2
EA201700519A2 EA201700519A EA201700519A EA201700519A2 EA 201700519 A2 EA201700519 A2 EA 201700519A2 EA 201700519 A EA201700519 A EA 201700519A EA 201700519 A EA201700519 A EA 201700519A EA 201700519 A2 EA201700519 A2 EA 201700519A2
Authority
EA
Eurasian Patent Office
Prior art keywords
carbapenems
klebsiella pneumoniae
bacteria
lactamaz
gramoratoral
Prior art date
Application number
EA201700519A
Other languages
Russian (ru)
Other versions
EA201700519A3 (en
Inventor
Анна Геннадьевна Афиногенова
Татьяна Михайловна Ворошилова
Геннадий Евгеньевич Афиногенов
Original Assignee
Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный университет" (СПбГУ)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный университет" (СПбГУ) filed Critical Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный университет" (СПбГУ)
Publication of EA201700519A2 publication Critical patent/EA201700519A2/en
Publication of EA201700519A3 publication Critical patent/EA201700519A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Изобретение относится к области медицины, в частности к клинической микробиологии, и может быть использовано для преодоления устойчивости грамотрицательных бактерий вида Klebsiella pneumoniae, продуцирующих металло-β-лактамазу (МβЛ), к карбапенемам. Указанный технический результат достигается тем, что клодроновая или этидроновая кислоты из группы бисфосфонатов ингибируют стандартный реактив - металло-β-лактамазу P.aeruginosa, рекомбинантную, экспрессированную в Escherichia coli. Достигнутый результат позволил выявить антимикробный эффект комбинации клодроновой или этидроновой кислот с карбапенемами (имипенемом или меропенемом) в отношении референс-штамма K.pneumoniae АТСС 70603, резистентного к карбапенемам, в присутствии стандартного реактива МβЛ, инактивирующего эти антибиотики. Предложенное техническое решение позволяет моделировать получение штаммов грамотрицательных микроорганизмов с различным уровнем резистентности к карбапенемам и оценивать эффективность ингибирования МβЛ.The invention relates to the field of medicine, in particular to clinical microbiology, and can be used to overcome the resistance of Gram-negative bacteria of the species Klebsiella pneumoniae, producing metallo-β-lactamase (ML), to carbapenems. This technical result is achieved by the fact that clodronic or etidronovy acid from the group of bisphosphonates inhibit the standard reagent - metallo-β-lactamase P. aeruginosa, recombinant, expressed in Escherichia coli. The achieved result allowed to reveal the antimicrobial effect of the combination of clodronic or etidronic acids with carbapenems (imipenem or meropenem) in relation to the reference strain K.pneumoniae ATCC 70603, resistant to carbapenems, in the presence of the standard МβЛ reactive inactivating these antibiotics The proposed solution allows to simulate the production of strains of gram-negative microorganisms with different levels of resistance to carbapenems and to assess the effectiveness of inhibition of MβL.

EA201700519A 2016-12-01 2017-11-23 ANTIMICROBIAL COMBINATION WITH RESPECT TO SUSTAINABLE CARBAPENES OF GRAMORATORAL BACTERIA OF KLEBSIELLA PNEUMONIAE KIND, PRODUCING METAL-β-LACTAMAZ EA201700519A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2016147242A RU2664434C2 (en) 2016-12-01 2016-12-01 Antimicrobial combination for carbapenem-resistant gram-negative bacteria of the type klebsiella pneumoniae producing metal-β-lactamase

Publications (2)

Publication Number Publication Date
EA201700519A2 true EA201700519A2 (en) 2018-08-31
EA201700519A3 EA201700519A3 (en) 2019-01-31

Family

ID=62557358

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201700519A EA201700519A3 (en) 2016-12-01 2017-11-23 ANTIMICROBIAL COMBINATION WITH RESPECT TO SUSTAINABLE CARBAPENES OF GRAMORATORAL BACTERIA OF KLEBSIELLA PNEUMONIAE KIND, PRODUCING METAL-β-LACTAMAZ

Country Status (2)

Country Link
EA (1) EA201700519A3 (en)
RU (1) RU2664434C2 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5888998A (en) * 1997-04-24 1999-03-30 Synphar Laboratories, Inc. 2-oxo-1-azetidine sulfonic acid derivatives as potent β-lactamase inhibitors
KR101590739B1 (en) * 2005-09-22 2016-02-01 메이지 세이카 파루마 가부시키가이샤 METALLO-β-LACTAMASE INHIBITOR
CN102475703A (en) * 2010-11-26 2012-05-30 丽珠医药集团股份有限公司 Anti-Acinetobacter baumannii drug combination and application thereof

Also Published As

Publication number Publication date
RU2664434C2 (en) 2018-08-17
RU2016147242A3 (en) 2018-06-05
RU2016147242A (en) 2018-06-05
EA201700519A3 (en) 2019-01-31

Similar Documents

Publication Publication Date Title
PH12019500360A1 (en) Antibiotic compounds
BR112014027818A2 (en) prevention, rupture and treatment of biofilm with bacteriophage lysine
BR112017020935A2 (en) "compounds, pharmaceutical composition and assembly"
WO2017017631A3 (en) Antibacterial therapeutics and prophylactics
BR112016006589A2 (en) composition, and vaccine composition
BR112017010132A2 (en) combination therapy for treatment of resistant bacterial infections
BR112014023321A2 (en) Compositions comprising antibacterial phages and their uses
TW201613575A (en) Treatment of polybacterial infections
WO2015112980A3 (en) Dermaseptin-type and piscidin-type antimicrobial peptides
CR20210618A (en) Compositions and methods for treating biofilm-related lung conditions
EP3574900A8 (en) New applications of rifamycin-nitroimidazole coupling molecules
ZA202002093B (en) Antibacterial compounds
BR112022007926A2 (en) COCKTAIL COMPOSITIONS INCLUDING RESPIRATORY ANTIBACTERIAL PHAGES AND METHODS OF USE THEREOF
WO2013041663A3 (en) Modified apidaecin derivatives as antibiotic peptides
BR112014026861A2 (en) coagulase staphylococcal antigens and methods of use
MX2015015176A (en) Antimicrobial compositions and methods for their production.
EA201700519A3 (en) ANTIMICROBIAL COMBINATION WITH RESPECT TO SUSTAINABLE CARBAPENES OF GRAMORATORAL BACTERIA OF KLEBSIELLA PNEUMONIAE KIND, PRODUCING METAL-β-LACTAMAZ
WO2015114452A3 (en) Antibacterial combinations comprising polymyxin
EA201700518A3 (en) ANTIMICROBIAL COMBINATION WITH RESPECT TO THE SUSTAINABLE CARBAPENES OF THE GRAMORATORY BACTERIA OF ACINETOBACTER BAUMANNII KIND, PRODUCING METAL-β-LACTAMAZ
EA201791948A1 (en) BETA SPILLARY PEPTIDOMYMETICS
MY170829A (en) Fulvic acid and antibiotic combination for the inhibition or treatment of multi-drug resistant bacteria
GEP20197029B (en) Antimicrobial composition and the use of thereof
MY180113A (en) Use of patchouli extract in the preparation of compositions with an anti-microorganism effect
EA201892278A1 (en) ANBITACTERIAL BIAROMATIC DERIVATIVES WITH OXETHANE-3-ILOXY SUBSTITUTION
MX2019001280A (en) NOVEL PHARMACEUTICAL COMPOSITIONS WITH A MODIFIED BETA-DEFENSIN FUSION PEPTIDE HßD3-M AND COMMERCIAL ANTIBIOTICS FOR USE IN THE TREATMENT OF INFECTIONS WITH PATHOGENIC BACTERIA.