EA201691190A1 - SALT 3-CARBOXY-4- (R) -PHENYLPIRROLIDIN-2-IT AND ITS APPLICATION - Google Patents

SALT 3-CARBOXY-4- (R) -PHENYLPIRROLIDIN-2-IT AND ITS APPLICATION

Info

Publication number
EA201691190A1
EA201691190A1 EA201691190A EA201691190A EA201691190A1 EA 201691190 A1 EA201691190 A1 EA 201691190A1 EA 201691190 A EA201691190 A EA 201691190A EA 201691190 A EA201691190 A EA 201691190A EA 201691190 A1 EA201691190 A1 EA 201691190A1
Authority
EA
Eurasian Patent Office
Prior art keywords
carboxy
phenylpirrolidin
salt
application
phenylpyrrolidin
Prior art date
Application number
EA201691190A
Other languages
Russian (ru)
Other versions
EA027373B1 (en
Inventor
Галина Кухарева
Евгений Матюшенков
Original Assignee
Акционерное Общество "Олайнфарм"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Акционерное Общество "Олайнфарм" filed Critical Акционерное Общество "Олайнфарм"
Publication of EA201691190A1 publication Critical patent/EA201691190A1/en
Publication of EA027373B1 publication Critical patent/EA027373B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Новый способ получения 3-карбокси-4-(R)-фенилпирролидин-2-она из 3-карбокси-4-(R,S)-фенилпирролидин-2-она, согласно которому рацемическую смесь разделяют с помощью 3-(S)-бензоилоксихинуклидина.A new method of obtaining 3-carboxy-4- (R) -phenylpyrrolidin-2-one from 3-carboxy-4- (R, S) -phenylpyrrolidin-2-one, according to which the racemic mixture is separated using 3- (S) - benzoyloxyquinuclidine.

EA201691190A 2013-12-13 2014-12-12 Method for separating racemic 3-carboxy-4-phenylpyrrolydine-2-one using 3-(s)-benzoyloxyquinuclidine EA027373B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LVP-13-209A LV15015B (en) 2013-12-13 2013-12-13 Salt of 3-carboxy-4-(r)-phenylpyrrolidinone-2 and uses thereof
PCT/IB2014/066846 WO2015087291A1 (en) 2013-12-13 2014-12-12 3-carboxy-4-(r)-phenylpyrrolydine-2-one salt and its use

Publications (2)

Publication Number Publication Date
EA201691190A1 true EA201691190A1 (en) 2016-12-30
EA027373B1 EA027373B1 (en) 2017-07-31

Family

ID=52462958

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201691190A EA027373B1 (en) 2013-12-13 2014-12-12 Method for separating racemic 3-carboxy-4-phenylpyrrolydine-2-one using 3-(s)-benzoyloxyquinuclidine

Country Status (4)

Country Link
EA (1) EA027373B1 (en)
LV (1) LV15015B (en)
UA (1) UA114161C2 (en)
WO (1) WO2015087291A1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LV13635B (en) 2006-02-23 2008-01-20 Olainfarm As Enzymatic resolution of racemic 3-aryl-4-aminobutyric acids
LV13630B (en) 2006-03-16 2007-12-20 Olainfarm As Method of preparation and use of pharmaceutically active n-carbamoylmethyl-4(r)-phenyl-2-pyrrolidinone

Also Published As

Publication number Publication date
LV15015B (en) 2015-12-20
WO2015087291A1 (en) 2015-06-18
EA027373B1 (en) 2017-07-31
LV15015A (en) 2015-06-20
UA114161C2 (en) 2017-04-25

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