EA201691083A1 - INFLUENZA VIRUS REPLICATION INHIBITORS - Google Patents

INFLUENZA VIRUS REPLICATION INHIBITORS

Info

Publication number
EA201691083A1
EA201691083A1 EA201691083A EA201691083A EA201691083A1 EA 201691083 A1 EA201691083 A1 EA 201691083A1 EA 201691083 A EA201691083 A EA 201691083A EA 201691083 A EA201691083 A EA 201691083A EA 201691083 A1 EA201691083 A1 EA 201691083A1
Authority
EA
Eurasian Patent Office
Prior art keywords
patient
pharmaceutically acceptable
structural formula
virus replication
influenza virus
Prior art date
Application number
EA201691083A
Other languages
Russian (ru)
Inventor
Пол Чарифсон
Майкл П. Кларк
Упул К. Бандарадже
Рэнди С. Бетил
Джон Дж. Корт
Хунбо Дэн
Иоана Друту
Джон П. Даффи
Люк Фармер
Хуай Гао
Вэньсинь Гу
Дилан Х. Джейкобс
Джозеф М. Кеннеди
Марк В. Ледебур
Брайан Ледфорд
Франсуа Мальте
Эмануэле Перола
Тяньшэн Ван
М. Вудс Ваннамэйкер
Рэндал Бирн
Йи Чжоу
Чао Линь
Минь Цзян
Стивен Джоунс
Урсула А. Джерманн
Г. Салитуро Франческо
Дак-Йи Квон Энн
Original Assignee
Вертекс Фармасьютикалз Инкорпорейтед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Вертекс Фармасьютикалз Инкорпорейтед filed Critical Вертекс Фармасьютикалз Инкорпорейтед
Publication of EA201691083A1 publication Critical patent/EA201691083A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Способы ингибирования репликации вируса гриппа в биологическом образце или у пациента, уменьшения количества вирусов гриппа в биологическом образце или у пациента и лечения гриппа у пациента, которые включают введение в указанный биологический образец или пациенту эффективного количества соединения, представленного структурной формулой (I)или его фармацевтически приемлемой соли, где обозначения, указанные в структурной формуле (IA), представлены в описании выше. Соединение, представленное структурной формулой (IA), или его фармацевтически приемлемая соль, где обозначения, указанные в структурной формуле (IA), описаны выше. Фармацевтическая композиция, содержащая эффективное количество такого соединения или его фармацевтически приемлемой соли и фармацевтически приемлемый носитель, наполнитель или разбавитель.Methods of inhibiting influenza virus replication in a biological sample or in a patient, reducing the number of influenza viruses in a biological sample or in a patient, and treating influenza in a patient, which comprise administering to said biological sample or patient an effective amount of a compound represented by structural formula (I) or a pharmaceutically acceptable salt, where the symbols indicated in structural formula (IA) are presented in the description above. A compound represented by structural formula (IA), or a pharmaceutically acceptable salt thereof, wherein the symbols indicated in structural formula (IA) are described above. A pharmaceutical composition comprising an effective amount of such a compound or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier, excipient or diluent.

EA201691083A 2009-12-18 2010-06-17 INFLUENZA VIRUS REPLICATION INHIBITORS EA201691083A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28778109P 2009-12-18 2009-12-18

Publications (1)

Publication Number Publication Date
EA201691083A1 true EA201691083A1 (en) 2020-01-29

Family

ID=69374450

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201691083A EA201691083A1 (en) 2009-12-18 2010-06-17 INFLUENZA VIRUS REPLICATION INHIBITORS

Country Status (1)

Country Link
EA (1) EA201691083A1 (en)

Similar Documents

Publication Publication Date Title
EA201270032A1 (en) ANTI-FLY VIRUS REPLICATION INHIBITORS
UA118010C2 (en) INFLUENCES OF INFLUENZA VIRUS REPLICATION
MX2013006846A (en) Inhibitors of influenza viruses replication.
BR112013020042A2 (en) hepatitis c virus inhibitors
WO2012083122A8 (en) Inhibitors of influenza viruses replication
MY202109A (en) Viral replication inhibitors
EA201290089A1 (en) CHEMICAL COMPOUNDS
EA201791916A1 (en) 2'-SUBSTITUTED CARBANECULOSE ANALOGUES FOR ANTI-VIRUS TREATMENT
UY32062A (en) BETA-SECRETASA INHIBITORS
EA201590358A1 (en) Inhibitors of Human Immunodeficiency Virus Replication
EA201491179A1 (en) 2 ', 4'-DIFFOROR-2'-METHYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AS AN INHIBITORS REPLICATION RNA HEPATITIS C VIRUS
EA201270656A1 (en) HEPATITIS C VIRUS INHIBITORS
EA201370017A1 (en) HEPATITIS C VIRUS INHIBITORS
BR112013028679A2 (en) hepatitis c virus inhibitors
BR112014010401A8 (en) HEPATITIS C VIRUS ROD-LIKE INHIBITORS CONTAINING THE FRAGMENT {2-[4-(BIPHENYL-4-IL)-1H-IMIDAZO-2-IL] PYRROLIDINE-1-CARBONYLMETHYL}AMINE
EA201691083A1 (en) INFLUENZA VIRUS REPLICATION INHIBITORS
UA111703C2 (en) INFLUENCES OF Flu Virus Replication
PH12019501907A1 (en) Novel viral replication inhibitors
EA201990314A1 (en) NEW VIRAL REPLICATION INHIBITORS
TN2013000335A1 (en) Hepatitis c virus inhibitors
TN2013000453A1 (en) Hepatitis c virus inhibitors