EA201691018A1 - PHARMACEUTICAL COMPOSITION CONTAINING A MIXTURE OF PRODUCTS AND ENZYMES - Google Patents
PHARMACEUTICAL COMPOSITION CONTAINING A MIXTURE OF PRODUCTS AND ENZYMESInfo
- Publication number
- EA201691018A1 EA201691018A1 EA201691018A EA201691018A EA201691018A1 EA 201691018 A1 EA201691018 A1 EA 201691018A1 EA 201691018 A EA201691018 A EA 201691018A EA 201691018 A EA201691018 A EA 201691018A EA 201691018 A1 EA201691018 A1 EA 201691018A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- enzymes
- mixture
- pharmaceutical composition
- composition containing
- products
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
- C12N9/2411—Amylases
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6427—Chymotrypsins (3.4.21.1; 3.4.21.2); Trypsin (3.4.21.4)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
- C12Y301/01003—Triacylglycerol lipase (3.1.1.3)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01001—Alpha-amylase (3.2.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21001—Chymotrypsin (3.4.21.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21004—Trypsin (3.4.21.4)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biomedical Technology (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Фармацевтическая композиция, содержащая смесь проферментов и ферментов, содержащая проферменты: трипсиноген и химотрипсиноген и ферменты: α-амилазу и липазу в качестве активных веществ, и один или более фармацевтически приемлемых эксципиентов для одновременного, раздельного и последовательного введения композиции парентеральным или трансмукозальным путем, где композиция обладает антипролиферативными и антиметастатическими действиями в отношении раковых опухолей и предназначена для терапевтического, профилактического и антиметастатического применения у млекопитающих.A pharmaceutical composition containing a mixture of pro-enzymes and enzymes, containing pro-enzymes: trypsinogen and chymotrypsinogen and enzymes: α-amylase and lipase as active substances, and one or more pharmaceutically acceptable excipients for simultaneous, separate and sequential administration of the composition by parenteral or transmucosal route, where the composition possesses antiproliferative and antimetastatic actions against cancer tumors and is intended for therapeutic, prophylactic and antimette taticheskogo use in mammals.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CZ2013-891A CZ307195B6 (en) | 2013-11-18 | 2013-11-18 | A pharmaceutical composition comprising a mixture of proenzymes and enzymes |
PCT/CZ2014/000133 WO2015070828A1 (en) | 2013-11-18 | 2014-11-12 | Pharmaceutical composition containing a mixture of proenzymes and enzymes |
Publications (3)
Publication Number | Publication Date |
---|---|
EA201691018A1 true EA201691018A1 (en) | 2016-11-30 |
EA033123B1 EA033123B1 (en) | 2019-08-30 |
EA033123B9 EA033123B9 (en) | 2019-10-31 |
Family
ID=67353809
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201691018A EA033123B9 (en) | 2013-11-18 | 2014-11-12 | Anti-proliferative and anti-metastatic pharmaceutical composition and method of treating cancer |
Country Status (16)
Country | Link |
---|---|
US (2) | US20160339085A1 (en) |
EP (1) | EP3071218B1 (en) |
JP (1) | JP6568095B2 (en) |
CY (1) | CY1121276T1 (en) |
CZ (1) | CZ307195B6 (en) |
DK (1) | DK3071218T3 (en) |
EA (1) | EA033123B9 (en) |
ES (1) | ES2707376T3 (en) |
HR (1) | HRP20182155T1 (en) |
HU (1) | HUE042667T2 (en) |
LT (1) | LT3071218T (en) |
PL (1) | PL3071218T3 (en) |
PT (1) | PT3071218T (en) |
RS (1) | RS58296B1 (en) |
SI (1) | SI3071218T1 (en) |
WO (1) | WO2015070828A1 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20121709A1 (en) * | 2009-10-22 | 2012-12-17 | Propanc Pty Ltd | A PHARMACEUTICAL COMPOSITION TO TREAT CANCER INCLUDING TRYPSINOGEN AND / OR CHEMOTRIPSINOGEN AND AN ACTIVE AGENT SELECTED FROM A SELENIUM COMPOUND, A VAINILLOID COMPOUND AND A CYTOPLASMIC GLYCOLYSIS REDUCING AGENT |
CZ307195B6 (en) | 2013-11-18 | 2018-03-14 | František Trnka | A pharmaceutical composition comprising a mixture of proenzymes and enzymes |
SG11201803531XA (en) * | 2015-11-12 | 2018-05-30 | Propanc Pty Ltd | Proenzyme composition |
CN105385669A (en) * | 2015-11-24 | 2016-03-09 | 青岛康原药业有限公司 | Method for extracting prekallikrein by secondary affinity chromatography and pharmaceutical composition for improving stability of prekallikrein |
DK3407909T3 (en) * | 2016-01-29 | 2023-11-13 | Propanc Pty Ltd | CANCER TREATMENT |
WO2017177270A1 (en) * | 2016-04-12 | 2017-10-19 | Propanc Pty Ltd | Composition of proenzymes for cancer treatment |
DK3335696T3 (en) * | 2016-12-15 | 2020-03-16 | Upm Kymmene Corp | Process for drying cell-free tissue extract in a hydrogel comprising nanofibrillar cellulose and a dried hydrogel comprising nanofibrillar cellulose and cell-free tissue extract |
WO2021009768A1 (en) * | 2019-07-12 | 2021-01-21 | Lovely Professional University | An oral pharmaceutical composition for alpha- amylase inhibition |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4514388A (en) * | 1983-03-22 | 1985-04-30 | Psaledakis Nicholas G | Proteolytic enzymes in the zymogen form to treat sarcoma cells |
US4844897A (en) | 1985-09-13 | 1989-07-04 | Hiroshi Maeda | Anti-tumor protease preparations |
CZ283972B6 (en) | 1995-05-17 | 1998-07-15 | František Mudr. Trnka | Pharmaceutical preparation exhibiting modulation effect on malignant tumors and the use thereof |
US6087558A (en) | 1998-07-22 | 2000-07-11 | Prodigene, Inc. | Commercial production of proteases in plants |
US6019468A (en) | 1998-10-02 | 2000-02-01 | Altemare, Jr.; Kenneth D. | Spectacle kit |
US6428785B1 (en) * | 1999-10-28 | 2002-08-06 | Immunolytics Inc. | Method and composition for treating prostate cancer |
AU2008218595B2 (en) * | 2007-02-20 | 2012-05-24 | Allergan Therapeutics LLC | Stable digestive enzyme compositions |
PE20121709A1 (en) | 2009-10-22 | 2012-12-17 | Propanc Pty Ltd | A PHARMACEUTICAL COMPOSITION TO TREAT CANCER INCLUDING TRYPSINOGEN AND / OR CHEMOTRIPSINOGEN AND AN ACTIVE AGENT SELECTED FROM A SELENIUM COMPOUND, A VAINILLOID COMPOUND AND A CYTOPLASMIC GLYCOLYSIS REDUCING AGENT |
CZ201124A3 (en) | 2011-01-17 | 2012-06-13 | Elmarco S.R.O. | Carrier for oromucosal, especially sublingual application of physiologically active compounds |
CN102949712A (en) * | 2011-08-21 | 2013-03-06 | 李红彬 | Chinese and western composite medicine for treating neoplastic diseases |
US10087401B2 (en) | 2012-03-16 | 2018-10-02 | Monosol, Llc | Water soluble compositions incorporating enzymes, and method of making same |
CZ307195B6 (en) | 2013-11-18 | 2018-03-14 | František Trnka | A pharmaceutical composition comprising a mixture of proenzymes and enzymes |
-
2013
- 2013-11-18 CZ CZ2013-891A patent/CZ307195B6/en unknown
-
2014
- 2014-11-12 HU HUE14814733A patent/HUE042667T2/en unknown
- 2014-11-12 LT LTEP14814733.3T patent/LT3071218T/en unknown
- 2014-11-12 SI SI201431004T patent/SI3071218T1/en unknown
- 2014-11-12 EP EP14814733.3A patent/EP3071218B1/en active Active
- 2014-11-12 PL PL14814733T patent/PL3071218T3/en unknown
- 2014-11-12 RS RS20190120A patent/RS58296B1/en unknown
- 2014-11-12 PT PT14814733T patent/PT3071218T/en unknown
- 2014-11-12 ES ES14814733T patent/ES2707376T3/en active Active
- 2014-11-12 DK DK14814733.3T patent/DK3071218T3/en active
- 2014-11-12 EA EA201691018A patent/EA033123B9/en unknown
- 2014-11-12 JP JP2016553704A patent/JP6568095B2/en active Active
- 2014-11-12 WO PCT/CZ2014/000133 patent/WO2015070828A1/en active Application Filing
- 2014-11-24 US US15/037,331 patent/US20160339085A1/en not_active Abandoned
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2018
- 2018-12-19 HR HRP20182155TT patent/HRP20182155T1/en unknown
-
2019
- 2019-01-14 CY CY20191100031T patent/CY1121276T1/en unknown
- 2019-02-21 US US16/281,130 patent/US11185587B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CZ2013891A3 (en) | 2015-05-27 |
HRP20182155T1 (en) | 2019-02-08 |
LT3071218T (en) | 2018-12-27 |
ES2707376T3 (en) | 2019-04-03 |
CY1121276T1 (en) | 2020-05-29 |
US20190247471A1 (en) | 2019-08-15 |
US20160339085A1 (en) | 2016-11-24 |
WO2015070828A1 (en) | 2015-05-21 |
JP2016538339A (en) | 2016-12-08 |
EA033123B9 (en) | 2019-10-31 |
EA033123B1 (en) | 2019-08-30 |
JP6568095B2 (en) | 2019-08-28 |
PL3071218T3 (en) | 2019-05-31 |
SI3071218T1 (en) | 2019-01-31 |
PT3071218T (en) | 2019-01-30 |
EP3071218B1 (en) | 2018-10-31 |
CZ307195B6 (en) | 2018-03-14 |
DK3071218T3 (en) | 2019-02-18 |
RS58296B1 (en) | 2019-03-29 |
US11185587B2 (en) | 2021-11-30 |
HUE042667T2 (en) | 2019-07-29 |
EP3071218A1 (en) | 2016-09-28 |
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