EA201592273A1 - REPEATED INTRODUCTION OF NON-IMMUNOSUPRESSIVE ANTIGENSPECIFIC IMMUNOTHERAPY - Google Patents

REPEATED INTRODUCTION OF NON-IMMUNOSUPRESSIVE ANTIGENSPECIFIC IMMUNOTHERAPY

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Publication number
EA201592273A1
EA201592273A1 EA201592273A EA201592273A EA201592273A1 EA 201592273 A1 EA201592273 A1 EA 201592273A1 EA 201592273 A EA201592273 A EA 201592273A EA 201592273 A EA201592273 A EA 201592273A EA 201592273 A1 EA201592273 A1 EA 201592273A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antigenspecific
immunosupressive
immunotherapy
repeated introduction
introduction
Prior art date
Application number
EA201592273A
Other languages
Russian (ru)
Inventor
Роберто А. Мальдонадо
Такаси Кеи Кисимото
Original Assignee
Селекта Байосайенсиз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Селекта Байосайенсиз, Инк. filed Critical Селекта Байосайенсиз, Инк.
Publication of EA201592273A1 publication Critical patent/EA201592273A1/en

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    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13Cyclosporins
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Abstract

Настоящее изобретение относится к повторному введению антигенспецифических иммунотерапевтических средств с использованием протоколов или их элементов, которые не индуцируют иммуносупрессию. Согласно некоторым вариантам осуществления ранее было показано, что указанный протокол не индуцирует иммуносупрессию у субъекта.The present invention relates to the re-introduction of antigen-specific immunotherapeutic agents using protocols or their elements that do not induce immunosuppression. According to some embodiments, it has previously been shown that this protocol does not induce immunosuppression in a subject.

EA201592273A 2013-06-04 2014-06-04 REPEATED INTRODUCTION OF NON-IMMUNOSUPRESSIVE ANTIGENSPECIFIC IMMUNOTHERAPY EA201592273A1 (en)

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Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2010254551B2 (en) 2009-05-27 2016-10-20 Selecta Biosciences, Inc. Immunomodulatory agent-polymeric compounds
CA2798323A1 (en) 2010-05-26 2011-12-01 Selecta Biosciences, Inc. Dose selection of adjuvanted synthetic nanocarriers
US9994443B2 (en) 2010-11-05 2018-06-12 Selecta Biosciences, Inc. Modified nicotinic compounds and related methods
CN103517707A (en) 2011-04-29 2014-01-15 西莱克塔生物科技公司 Controlled release of immunosuppressants from synthetic nanocarriers
US20130028857A1 (en) 2011-07-29 2013-01-31 Selecta Biosciences, Inc. Synthetic nanocarriers comprising polymers comprising multiple immunomodulatory agents
KR20220025909A (en) 2013-05-03 2022-03-03 셀렉타 바이오사이언시즈, 인크. Delivery of immunosuppressants having a specified pharmacodynamic effective-life and antigen for the inducation of immune tolerance
BR112017001470A2 (en) 2014-09-07 2018-02-20 Selecta Biosciences Inc methods and compositions for attenuating the immune responses of the gene therapy antiviral transfer vector
WO2017083659A1 (en) * 2015-11-12 2017-05-18 New York University Biodegradable polymeric nanoparticle conjugates and use thereof
US20180193482A1 (en) * 2017-01-07 2018-07-12 Selecta Biosciences, Inc. Patterned dosing of immunosuppressants coupled to synthetic nanocarriers
CN110612122A (en) 2017-03-11 2019-12-24 西莱克塔生物科技公司 Methods and compositions related to combination therapy with anti-inflammatory agents and synthetic nanocarriers comprising immunosuppressants
AU2018375151A1 (en) * 2017-11-29 2020-06-11 Figene, Llc Interaction of fibroblasts and immune cells for activation and uses thereof
JP2022506683A (en) 2018-11-04 2022-01-17 フィジーン、エルエルシー Treatment and Composition of Type 1 Diabetes Using Fibroblasts as Facilitator for Pancreas Transplantation
KR102490400B1 (en) * 2022-07-26 2023-01-25 서울대학교산학협력단 Composition for treating or prventing osteoarthritis

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946929A (en) 1983-03-22 1990-08-07 Massachusetts Institute Of Technology Bioerodible articles useful as implants and prostheses having predictable degradation rates
US4638045A (en) 1985-02-19 1987-01-20 Massachusetts Institute Of Technology Non-peptide polyamino acid bioerodible polymers
US4806621A (en) 1986-01-21 1989-02-21 Massachusetts Institute Of Technology Biocompatible, bioerodible, hydrophobic, implantable polyimino carbonate article
CA1340581C (en) 1986-11-20 1999-06-08 Joseph P. Vacanti Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices
US5759830A (en) 1986-11-20 1998-06-02 Massachusetts Institute Of Technology Three-dimensional fibrous scaffold containing attached cells for producing vascularized tissue in vivo
US5736372A (en) 1986-11-20 1998-04-07 Massachusetts Institute Of Technology Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure
US5019379A (en) 1987-07-31 1991-05-28 Massachusetts Institute Of Technology Unsaturated polyanhydrides
US5010167A (en) 1989-03-31 1991-04-23 Massachusetts Institute Of Technology Poly(amide-and imide-co-anhydride) for biological application
US5399665A (en) 1992-11-05 1995-03-21 Massachusetts Institute Of Technology Biodegradable polymers for cell transplantation
US5512600A (en) 1993-01-15 1996-04-30 Massachusetts Institute Of Technology Preparation of bonded fiber structures for cell implantation
US5514378A (en) 1993-02-01 1996-05-07 Massachusetts Institute Of Technology Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures
US5565215A (en) 1993-07-23 1996-10-15 Massachusettes Institute Of Technology Biodegradable injectable particles for imaging
US5543158A (en) 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
US6007845A (en) 1994-07-22 1999-12-28 Massachusetts Institute Of Technology Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers
US5716404A (en) 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
US6123727A (en) 1995-05-01 2000-09-26 Massachusetts Institute Of Technology Tissue engineered tendons and ligaments
US6095148A (en) 1995-11-03 2000-08-01 Children's Medical Center Corporation Neuronal stimulation using electrically conducting polymers
US5902599A (en) 1996-02-20 1999-05-11 Massachusetts Institute Of Technology Biodegradable polymer networks for use in orthopedic and dental applications
US5837752A (en) 1997-07-17 1998-11-17 Massachusetts Institute Of Technology Semi-interpenetrating polymer networks
US6632922B1 (en) 1998-03-19 2003-10-14 The Regents Of The University Of California Methods and compositions for controlled polypeptide synthesis
US6506577B1 (en) 1998-03-19 2003-01-14 The Regents Of The University Of California Synthesis and crosslinking of catechol containing copolypeptides
US6686446B2 (en) 1998-03-19 2004-02-03 The Regents Of The University Of California Methods and compositions for controlled polypeptide synthesis
AU4724401A (en) 2000-02-28 2001-09-12 Genesegues Inc Nanocapsule encapsulation system and method
CA2407897A1 (en) 2000-05-05 2001-11-15 Cytos Biotechnology Ag Molecular antigen arrays and vaccines
CA2319928A1 (en) 2000-09-18 2002-03-18 Vasogen Ireland Limited Apoptosis-mimicking synthetic entities and use thereof in medical treatments
GB0025414D0 (en) 2000-10-16 2000-11-29 Consejo Superior Investigacion Nanoparticles
US6818732B2 (en) 2001-08-30 2004-11-16 The Regents Of The University Of California Transition metal initiators for controlled poly (beta-peptide) synthesis from beta-lactam monomers
EP1549277A4 (en) * 2002-05-22 2007-09-05 Cleveland Clinic Foundation Induction and maintenance of tolerance to composite tissue allografts
WO2004085635A1 (en) 2003-03-26 2004-10-07 Cytos Biotechnology Ag Melan-a peptide analogue-virus-like-particle conjugates
JP6067954B2 (en) 2003-12-19 2017-01-25 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒルThe University Of North Carolina At Chapel Hill Nano-sized article and nano-sized article manufactured by a method for producing a separation structure using soft lithography or imprint lithography
EP1768692B8 (en) 2004-07-01 2015-06-17 Yale University Targeted and high density drug loaded polymeric materials
EP2077821B1 (en) * 2006-10-12 2019-08-14 The University Of Queensland Compositions and methods for modulating immune responses
JP5650406B2 (en) 2007-03-07 2015-01-07 ユーティーアイ リミテッド パートナーシップ Compositions and methods for prevention and treatment of autoimmune conditions
AU2008236566A1 (en) 2007-04-09 2008-10-16 Chimeros, Inc. Self-assembling nanoparticle drug delivery system
JP2010523656A (en) 2007-04-12 2010-07-15 エモリー・ユニバーシティ A novel strategy for active substance delivery using micelles and particles
ES2627292T3 (en) 2007-10-12 2017-07-27 Massachusetts Institute Of Technology Vaccine Nanotechnology
EP2262489A2 (en) 2008-02-28 2010-12-22 Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts Hollow nanoparticles and uses thereof
WO2010047839A1 (en) 2008-10-25 2010-04-29 Aura Biosciences Modified plant virus particles and uses therefor
WO2010056143A1 (en) * 2008-11-13 2010-05-20 Instituto De Medicina Molecular The use of adjuvant to facilitate the induction of immune tolerance
CN102325546A (en) 2009-01-20 2012-01-18 西北大学 The compositions and the method that are used for inducing antigen-specificity tolerance
AU2010254551B2 (en) * 2009-05-27 2016-10-20 Selecta Biosciences, Inc. Immunomodulatory agent-polymeric compounds
AU2011289579B2 (en) * 2010-08-10 2016-11-17 Ecole Polytechnique Federale De Lausanne Erythrocyte-binding therapeutics
EP2630493A4 (en) * 2010-10-22 2014-05-21 Univ Florida Antigen-specific, tolerance-inducing microparticles and uses thereof
CA2831613A1 (en) 2011-03-31 2012-10-04 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
CN103517707A (en) * 2011-04-29 2014-01-15 西莱克塔生物科技公司 Controlled release of immunosuppressants from synthetic nanocarriers
ES2836823T3 (en) * 2011-05-16 2021-06-28 Genzyme Corp Induction of Immune Tolerance Using Methotrexate
CN110511939A (en) 2011-10-03 2019-11-29 现代泰克斯公司 Nucleosides, nucleotide and nucleic acid of modification and application thereof

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