EA201491213A1 - ANTAGONISTS TRPM8 - Google Patents

ANTAGONISTS TRPM8

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Publication number
EA201491213A1
EA201491213A1 EA201491213A EA201491213A EA201491213A1 EA 201491213 A1 EA201491213 A1 EA 201491213A1 EA 201491213 A EA201491213 A EA 201491213A EA 201491213 A EA201491213 A EA 201491213A EA 201491213 A1 EA201491213 A1 EA 201491213A1
Authority
EA
Eurasian Patent Office
Prior art keywords
trpm8
disorders
antagonists
compounds
neurodegeneration
Prior art date
Application number
EA201491213A
Other languages
Russian (ru)
Other versions
EA025356B1 (en
Inventor
Алессио Морикони
Джанлука Бьянкини
Сандро Коладжоя
Лаура Брандолини
Андреа Арамини
Кьяра Либерати
Сильвия Боволента
Original Assignee
Домпе' С.П.А.
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Publication date
Priority claimed from EP11194365.0A external-priority patent/EP2606888A1/en
Application filed by Домпе' С.П.А. filed Critical Домпе' С.П.А.
Publication of EA201491213A1 publication Critical patent/EA201491213A1/en
Publication of EA025356B1 publication Critical patent/EA025356B1/en

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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
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    • A61K31/425—Thiazoles
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/47—Quinolines; Isoquinolines
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    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Organic Chemistry (AREA)
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  • Veterinary Medicine (AREA)
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  • Urology & Nephrology (AREA)
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  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Изобретение относится к соединениям, действующим как селективные антагонисты члена 8 подсемейства М катионного канала транзиторного рецепторного потенциала (TRPM8) и имеющим формулу (I). Указанные соединения применимы при лечении заболеваний, связанных с активностью TRPM8, таких как боль, воспаление, ишемия, нейродегенерация, удар, психические расстройства, зуд, болезни раздраженного кишечника, вызванные холодом и обостренные респираторные расстройства и урологические расстройства.The invention relates to compounds acting as selective antagonists of member 8 of the subfamily M cation channel transient receptor potential (TRPM8) and having the formula (I). These compounds are useful in the treatment of diseases associated with TRPM8 activity, such as pain, inflammation, ischemia, neurodegeneration, stroke, mental disorders, itching, irritable bowel diseases caused by cold and exacerbated respiratory disorders and urological disorders.

EA201491213A 2011-12-19 2012-12-19 Trpm8 antagonists EA025356B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11194365.0A EP2606888A1 (en) 2011-12-19 2011-12-19 Trpm8 antagonists
EP12178327 2012-07-27
PCT/EP2012/076147 WO2013092711A1 (en) 2011-12-19 2012-12-19 Trpm8 antagonists

Publications (2)

Publication Number Publication Date
EA201491213A1 true EA201491213A1 (en) 2014-11-28
EA025356B1 EA025356B1 (en) 2016-12-30

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EA201491213A EA025356B1 (en) 2011-12-19 2012-12-19 Trpm8 antagonists

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US (2) US9585875B2 (en)
EP (1) EP2793883B1 (en)
JP (2) JP6238906B2 (en)
KR (1) KR102000319B1 (en)
CN (1) CN104220069B (en)
AU (1) AU2012357747B2 (en)
CY (1) CY1120403T1 (en)
DK (1) DK2793883T3 (en)
EA (1) EA025356B1 (en)
ES (1) ES2676884T3 (en)
HK (1) HK1203810A1 (en)
HR (1) HRP20181086T1 (en)
HU (1) HUE038407T2 (en)
LT (1) LT2793883T (en)
ME (1) ME03038B (en)
PL (1) PL2793883T3 (en)
PT (1) PT2793883T (en)
RS (1) RS57389B1 (en)
SI (1) SI2793883T1 (en)
TR (1) TR201808861T4 (en)
WO (1) WO2013092711A1 (en)
ZA (1) ZA201404499B (en)

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