EA201290592A1 - METHOD OF OBTAINING STRONTIUM RANELATE - Google Patents

METHOD OF OBTAINING STRONTIUM RANELATE

Info

Publication number
EA201290592A1
EA201290592A1 EA201290592A EA201290592A EA201290592A1 EA 201290592 A1 EA201290592 A1 EA 201290592A1 EA 201290592 A EA201290592 A EA 201290592A EA 201290592 A EA201290592 A EA 201290592A EA 201290592 A1 EA201290592 A1 EA 201290592A1
Authority
EA
Eurasian Patent Office
Prior art keywords
oxido
oxoethyl
strontium ranelate
obtaining strontium
thiophene
Prior art date
Application number
EA201290592A
Other languages
Russian (ru)
Inventor
Шандор Гараднаи
Николетта Сальма
Йожеф Неу
Йожеф Тёрлеи
Адам Деметер
Original Assignee
Рихтер Гедеон Нирт.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рихтер Гедеон Нирт. filed Critical Рихтер Гедеон Нирт.
Publication of EA201290592A1 publication Critical patent/EA201290592A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D333/40—Thiophene-2-carboxylic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Настоящее изобретение относится к способу синтеза 5-[бис(2-оксидо-2-оксоэтил)амино]-4-циано-3-(2-оксидо-2-оксоэтил)тиофен-2-карбоксилата дистронция (ранелата стронция) формулы (I), начиная с нового соединения формулы (II) 5-[бис(2-оксидо-2-оксоэтил)амино]-4-циано-3-(2-оксидо-2-оксоэтил)тиофен-2-карбоксилата тетрааммония, которое также является предметом изобретения.The present invention relates to a method for the synthesis of distrontium 5-[bis(2-oxido-2-oxoethyl)amino]-4-cyano-3-(2-oxido-2-oxoethyl)thiophene-2-carboxylate (strontium ranelate) of formula (I ), starting with a new compound of formula (II) tetraammonium 5-[bis(2-oxido-2-oxoethyl)amino]-4-cyano-3-(2-oxido-2-oxoethyl)thiophene-2-carboxylate, which also is the subject of the invention.

EA201290592A 2010-01-14 2011-01-14 METHOD OF OBTAINING STRONTIUM RANELATE EA201290592A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU1000018A HU228820B1 (en) 2010-01-14 2010-01-14 Process for the preparation of distrontium ranelate
PCT/HU2011/000006 WO2011086399A1 (en) 2010-01-14 2011-01-14 Process for the preparation of strontium ranelate

Publications (1)

Publication Number Publication Date
EA201290592A1 true EA201290592A1 (en) 2013-05-30

Family

ID=89989497

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201290592A EA201290592A1 (en) 2010-01-14 2011-01-14 METHOD OF OBTAINING STRONTIUM RANELATE

Country Status (4)

Country Link
EP (1) EP2523947A1 (en)
EA (1) EA201290592A1 (en)
HU (1) HU228820B1 (en)
WO (1) WO2011086399A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1398542B1 (en) * 2010-03-05 2013-03-01 Chemelectiva S R L PROCESS FOR THE PREPARATION OF A POLIMORFO
US8569514B1 (en) 2012-05-17 2013-10-29 Divi's Laboratories, Ltd. Process for the preparation of strontium ranelate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2651497B1 (en) 1989-09-01 1991-10-25 Adir NOVEL SALTS OF BIVALENT METALS OF N, N-DI ACID (CARBOXYMETHYL) AMINO-2 CYANO-3 CARBOXYMETHYL-4 CARBOXY-5 THIOPHENE, THEIR PREPARATION METHOD AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
FR2844795B1 (en) 2002-09-24 2004-10-22 Servier Lab NEW PROCESS FOR THE INDUSTRIAL SYNTHESIS OF STRONTIUM RANELATE AND ITS HYDRATES
AU2006281157B2 (en) 2005-08-19 2013-03-28 Glenmark Pharmaceuticals Limited Process for the preparation of strontium ranelate
FR2921367B1 (en) 2007-09-26 2009-10-30 Servier Lab NEW PROCESS FOR THE SYNTHESIS OF STRONTIUM RANELATE AND ITS HYDRATES

Also Published As

Publication number Publication date
HU1000018D0 (en) 2010-03-29
EP2523947A1 (en) 2012-11-21
HUP1000018A2 (en) 2011-10-28
WO2011086399A1 (en) 2011-07-21
HU228820B1 (en) 2013-05-28

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