EA201270376A1 - ANTHRAINEDIOXYMES AND THEIR APPLICATION - Google Patents

ANTHRAINEDIOXYMES AND THEIR APPLICATION

Info

Publication number
EA201270376A1
EA201270376A1 EA201270376A EA201270376A EA201270376A1 EA 201270376 A1 EA201270376 A1 EA 201270376A1 EA 201270376 A EA201270376 A EA 201270376A EA 201270376 A EA201270376 A EA 201270376A EA 201270376 A1 EA201270376 A1 EA 201270376A1
Authority
EA
Eurasian Patent Office
Prior art keywords
anthrainedioxymes
application
derivatives
compounds
cancer
Prior art date
Application number
EA201270376A
Other languages
Russian (ru)
Other versions
EA022290B1 (en
Inventor
Веслав М. Холодий
И Цзан
Карина Зук
Джеффри В.Х. Уоттхи
Зое Охлер
Джеффри Стровел
Норман Е. Охлер
Шила Челлаппан
Джанак Падия
Original Assignee
Форест Лэборетериз Холдингз Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Форест Лэборетериз Холдингз Лимитед filed Critical Форест Лэборетериз Холдингз Лимитед
Publication of EA201270376A1 publication Critical patent/EA201270376A1/en
Publication of EA022290B1 publication Critical patent/EA022290B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems

Abstract

В изобретении раскрыты антрахинондиоксимы и их производные для применения в лечении заболеваний, в частности рака, например рака толстой кишки и колоректального рака. Кроме того, в изобретении представлены способы синтеза упомянутых производных. Также описаны композиции этих соединений и метаболиты указанных соединений, а также их применение в модулировании генов.The invention discloses anthraquinondioximes and their derivatives for use in the treatment of diseases, in particular cancer, for example colon cancer and colorectal cancer. In addition, the invention provides methods for synthesizing said derivatives. Also described are the compositions of these compounds and the metabolites of these compounds, as well as their use in modulating genes.

EA201270376A 2008-11-21 2008-11-21 Anthraquinone dioximes and uses thereof EA022290B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2008/012995 WO2010059142A1 (en) 2008-11-21 2008-11-21 Anthraquinone dioximes and uses thereof

Publications (2)

Publication Number Publication Date
EA201270376A1 true EA201270376A1 (en) 2012-12-28
EA022290B1 EA022290B1 (en) 2015-12-30

Family

ID=42198382

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201500218A EA030302B1 (en) 2008-11-21 2008-11-21 Anthraquinone dioximes and use thereof
EA201270376A EA022290B1 (en) 2008-11-21 2008-11-21 Anthraquinone dioximes and uses thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA201500218A EA030302B1 (en) 2008-11-21 2008-11-21 Anthraquinone dioximes and use thereof

Country Status (2)

Country Link
EA (2) EA030302B1 (en)
WO (1) WO2010059142A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013067547A1 (en) * 2011-11-06 2013-05-10 Beta Cat Pharmaceuticals, Llc METHODS FOR TREATMENT OF DISEASES AND DISORDERS RELATED TO TRANSDUCIN β-LIKE PROTEIN 1 (TBL 1) ACTIVITY, INCLUDING MYELOPROLIFERATIVE NEOPLASIA AND CHRONIC MYELOID LEUKEMIA
TW201718495A (en) 2015-07-28 2017-06-01 貝塔貓製藥股份有限公司 Anthracene-9, 10-dione dioxime compound prodrugs and their uses
WO2017058716A1 (en) * 2015-09-28 2017-04-06 Vivace Therapeutics, Inc. Tricyclic compounds
CN105837478B (en) * 2016-04-20 2017-11-14 成都理工大学 As P2X3And P2X2/3The double 9 oxime derivates of double sulfonyl amerantrones of receptor antagonist
EP3630101A4 (en) 2017-06-02 2021-01-20 Iterion Therapeutics, Inc. Methods for treatment of fibrotic diseases

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3627791A (en) * 1968-11-21 1971-12-14 Richardson Merrell Inc Bis(aminoalkylsulfamoyl) anthraquinones
GB2025954A (en) * 1978-07-21 1980-01-30 Ciba Geigy Ag Anthraquinone Sulphonamides
GB2166453B (en) * 1984-08-01 1987-10-28 Ciba Geigy Ag Purification process
AU2003232785A1 (en) * 2002-07-17 2004-02-02 Zentaris Gmbh Novel anthracene derivatives and the use thereof as a medicament
US6693136B1 (en) * 2002-07-26 2004-02-17 Abbott Laboratories Fluorenes and anthracenes that inhibit P2X3 and P2X2/3 containing receptors
US6949557B2 (en) * 2003-04-29 2005-09-27 Dabur Research Foundation Hydroanthracene based compounds as anticancer agents

Also Published As

Publication number Publication date
WO2010059142A1 (en) 2010-05-27
EA022290B1 (en) 2015-12-30
EA201500218A1 (en) 2015-09-30
EA030302B1 (en) 2018-07-31

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM