EA201201233A1 - Nα-ACYLES - Google Patents

Nα-ACYLES

Info

Publication number
EA201201233A1
EA201201233A1 EA201201233A EA201201233A EA201201233A1 EA 201201233 A1 EA201201233 A1 EA 201201233A1 EA 201201233 A EA201201233 A EA 201201233A EA 201201233 A EA201201233 A EA 201201233A EA 201201233 A1 EA201201233 A1 EA 201201233A1
Authority
EA
Eurasian Patent Office
Prior art keywords
acyles
antihypoxic
cyanopyrrolidine
aminoacyl
neuroprotective
Prior art date
Application number
EA201201233A
Other languages
Russian (ru)
Other versions
EA021236B1 (en
Original Assignee
Дафот Энтерпраизес Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дафот Энтерпраизес Лимитед filed Critical Дафот Энтерпраизес Лимитед
Priority to EA201201233A priority Critical patent/EA021236B1/en
Priority to PCT/RU2013/000868 priority patent/WO2014054980A1/en
Publication of EA201201233A1 publication Critical patent/EA201201233A1/en
Publication of EA021236B1 publication Critical patent/EA021236B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Предметом настоящего изобретения являются nα-ацильные производные аминоацил-2-цианопирролидина - ингибиторы пролилэндопептидазы и дипептидилпептидазы-iv, обладающие гипогликемическим, противогипоксическим, нейропротекторным и улучшающим когнитивные функции действиемThe subject of the present invention is nα-acyl derivatives of aminoacyl-2-cyanopyrrolidine — prolyl endopeptidase and dipeptidyl peptidase-iv inhibitors having hypoglycemic, antihypoxic, neuroprotective and cognitive enhancing effects

EA201201233A 2012-10-03 2012-10-03 N-acyl derivatives of aminoacyl-2-cyanopyrrolidine - inhibitors of prolyl endopeptidase and dipeptidyl peptidase-iv, having hypoglycemic, antihypoxic, neuroprotective action and action of cognitive function improvement EA021236B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EA201201233A EA021236B1 (en) 2012-10-03 2012-10-03 N-acyl derivatives of aminoacyl-2-cyanopyrrolidine - inhibitors of prolyl endopeptidase and dipeptidyl peptidase-iv, having hypoglycemic, antihypoxic, neuroprotective action and action of cognitive function improvement
PCT/RU2013/000868 WO2014054980A1 (en) 2012-10-03 2013-10-02 Na-acyl derivatives of aminoacyl-2-cyanopyrrolidine-inhibitors of prolyl endopeptidase and dipeptidyl peptidase-iv, having hypoglycemic, antihypoxic, neuroprotective action and action of cognitive function improvement

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EA201201233A EA021236B1 (en) 2012-10-03 2012-10-03 N-acyl derivatives of aminoacyl-2-cyanopyrrolidine - inhibitors of prolyl endopeptidase and dipeptidyl peptidase-iv, having hypoglycemic, antihypoxic, neuroprotective action and action of cognitive function improvement

Publications (2)

Publication Number Publication Date
EA201201233A1 true EA201201233A1 (en) 2014-04-30
EA021236B1 EA021236B1 (en) 2015-05-29

Family

ID=49883191

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201201233A EA021236B1 (en) 2012-10-03 2012-10-03 N-acyl derivatives of aminoacyl-2-cyanopyrrolidine - inhibitors of prolyl endopeptidase and dipeptidyl peptidase-iv, having hypoglycemic, antihypoxic, neuroprotective action and action of cognitive function improvement

Country Status (2)

Country Link
EA (1) EA021236B1 (en)
WO (1) WO2014054980A1 (en)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW492957B (en) * 1996-11-07 2002-07-01 Novartis Ag N-substituted 2-cyanopyrrolidnes
GB9928330D0 (en) * 1999-11-30 2000-01-26 Ferring Bv Novel antidiabetic agents
DK1741445T3 (en) * 2000-01-21 2013-11-04 Novartis Ag Combinations comprising dipeptidyl peptidase IV inhibitors and antidiabetic agents
EP1354882A1 (en) * 2000-12-27 2003-10-22 Kyowa Hakko Kogyo Co., Ltd. Dipeptidyl peptidase iv inhibitor
BR0311535A (en) * 2002-06-03 2005-02-22 Novartis Ag Use of substituted cyanopyrrolidines and combination preparations containing them for the treatment of hyperlipidemia and associated diseases
CA2555399A1 (en) * 2004-02-20 2005-09-01 Novartis Ag Dpp-iv inhibitors for treating neurodegeneration and cognitive disorders
EP1760076A1 (en) * 2005-09-02 2007-03-07 Ferring B.V. FAP Inhibitors

Also Published As

Publication number Publication date
WO2014054980A1 (en) 2014-04-10
EA021236B1 (en) 2015-05-29

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KG TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY KZ RU