EA201101663A1 - COVALENT CONJUGATE OF POLYETHYLENE GLYCOL WITH GRANULOCITARIAN COLONIUS STIMULATING FACTOR OF THE PERSON - Google Patents

COVALENT CONJUGATE OF POLYETHYLENE GLYCOL WITH GRANULOCITARIAN COLONIUS STIMULATING FACTOR OF THE PERSON

Info

Publication number
EA201101663A1
EA201101663A1 EA201101663A EA201101663A EA201101663A1 EA 201101663 A1 EA201101663 A1 EA 201101663A1 EA 201101663 A EA201101663 A EA 201101663A EA 201101663 A EA201101663 A EA 201101663A EA 201101663 A1 EA201101663 A1 EA 201101663A1
Authority
EA
Eurasian Patent Office
Prior art keywords
stimulating factor
person
polyethylene glycol
granulocitarian
colonius
Prior art date
Application number
EA201101663A
Other languages
Russian (ru)
Other versions
EA020425B1 (en
Inventor
Сергей Викторович Шереметьев
Сергей Анатольевич Коровкин
Антон Викентьевич Катлинский
Андрей Викторович Семченко
Владимир Антонович Катлинский
Original Assignee
Общество С Ограниченной Ответственностью "Форт" (Ооо "Форт")
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Общество С Ограниченной Ответственностью "Форт" (Ооо "Форт") filed Critical Общество С Ограниченной Ответственностью "Форт" (Ооо "Форт")
Priority to EA201101663A priority Critical patent/EA020425B1/en
Publication of EA201101663A1 publication Critical patent/EA201101663A1/en
Publication of EA020425B1 publication Critical patent/EA020425B1/en

Links

Abstract

Изобретение относится к медицине и биотехнологии и касается ковалентного конъюгата полиэтиленгликоля с гранулоцитарным колониестимулирующим фактором человека, в котором ПЕГ присоединен к тирозиновым или гистидиновым фрагментам полипепетида посредством азогруппы общей структуры (I)где n - целое число в интервале от 100 до 1200; А - аминокислотный фрагмент тирозина или гистидина; Г-КСФ - гранулоцитарный колониестимулирующий фактор. Конъюгат Г-КСФ обладает большим временем циркуляции в кровотоке по сравнению с немодифицированным полипепетидом при сохранении существенной доли его активности.The invention relates to medicine and biotechnology and relates to a covalent conjugate of polyethylene glycol with a granulocyte colony-stimulating factor of a person, in which PEG is attached to the tyrosine or histidine fragments of polypeptide by the azo group of general structure (I) where n is an integer in the range from 100 to 1200; A - amino acid fragment of tyrosine or histidine; G-CSF - granulocyte colony-stimulating factor. The G-CSF conjugate has a longer circulation time in the bloodstream compared with the unmodified polypeptide, while maintaining a significant proportion of its activity.

EA201101663A 2011-12-21 2011-12-21 Polyethyleneglycol covalent conjugate with granulocytic colony-stimulating human factor EA020425B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EA201101663A EA020425B1 (en) 2011-12-21 2011-12-21 Polyethyleneglycol covalent conjugate with granulocytic colony-stimulating human factor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EA201101663A EA020425B1 (en) 2011-12-21 2011-12-21 Polyethyleneglycol covalent conjugate with granulocytic colony-stimulating human factor

Publications (2)

Publication Number Publication Date
EA201101663A1 true EA201101663A1 (en) 2013-06-28
EA020425B1 EA020425B1 (en) 2014-11-28

Family

ID=48699367

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201101663A EA020425B1 (en) 2011-12-21 2011-12-21 Polyethyleneglycol covalent conjugate with granulocytic colony-stimulating human factor

Country Status (1)

Country Link
EA (1) EA020425B1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA029942B1 (en) * 2014-06-16 2018-06-29 Общество С Ограниченной Ответственностью "Форт" (Ооо "Форт") Stable pharmaceutical composition based on conjugates of biologically active proteins with polyethylene glycol containing an azo group

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2749509C1 (en) * 2020-07-28 2021-06-11 Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) Targeted colony-stimulating agent

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0816381B1 (en) * 1995-03-10 2004-01-14 NAKAMURA, Toshikazu Polyethylene glycol modified hepatocyte growth factor (hgf)
RU2400490C2 (en) * 2003-12-03 2010-09-27 Биодженерикс Аг Glyco-peg granulocyte colony-stimulating factor

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA029942B1 (en) * 2014-06-16 2018-06-29 Общество С Ограниченной Ответственностью "Форт" (Ооо "Форт") Stable pharmaceutical composition based on conjugates of biologically active proteins with polyethylene glycol containing an azo group

Also Published As

Publication number Publication date
EA020425B1 (en) 2014-11-28

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KG MD TJ TM