EA201070055A1 - N-OXIDES OF VENLAFAXIN AND O-DESMETHYL VENLAFAXIN AS PROCEDURES - Google Patents

N-OXIDES OF VENLAFAXIN AND O-DESMETHYL VENLAFAXIN AS PROCEDURES

Info

Publication number
EA201070055A1
EA201070055A1 EA201070055A EA201070055A EA201070055A1 EA 201070055 A1 EA201070055 A1 EA 201070055A1 EA 201070055 A EA201070055 A EA 201070055A EA 201070055 A EA201070055 A EA 201070055A EA 201070055 A1 EA201070055 A1 EA 201070055A1
Authority
EA
Eurasian Patent Office
Prior art keywords
venlafaxin
venlafaxine
oxides
desmethyl
oxide
Prior art date
Application number
EA201070055A
Other languages
Russian (ru)
Inventor
Лехослав А. Турски
Аксел Стойт
Корнелис Г. Крюсе
Сандер Вадер
Мартинус Т.М. Тюлп
Original Assignee
Солвей Фармасьютикалс Б.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Солвей Фармасьютикалс Б.В. filed Critical Солвей Фармасьютикалс Б.В.
Publication of EA201070055A1 publication Critical patent/EA201070055A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Данное изобретение относится к N-оксиду венлафаксина и N-оксиду O-десметил венлафаксина в качестве пролекарств венлафаксина и его основного (активного) метаболита O-десметил венлафаксина, соответственно к фармацевтическим композициям, содержащим данные N-оксиды, к способам их получения и способам получения композиций. Данное изобретение относится к N-оксиду, имеющему формулу (1), в которой Rпредставляет собой Н или СН, и его таутомерам, стереоизомерам, гидратам и сольватам. Данное изобретение также относится к применениям N-оксидов и композиций, особенно для производства лекарственных средств, применяемых для лечения аффективных процессов или заболеваний, которые эффективно поддаются лечению - хотя и с побочными эффектами - венлафаксином.This invention relates to venlafaxine N-oxide and O-desmethyl venlafaxine N-oxide as prodrugs of venlafaxine and its main (active) metabolite O-desmethyl venlafaxine, respectively, to pharmaceutical compositions containing these N-oxides, to methods for their preparation and methods for their preparation compositions. This invention relates to an N-oxide having the formula (1), in which R represents H or CH, and its tautomers, stereoisomers, hydrates and solvates. This invention also relates to the use of N-oxides and compositions, especially for the manufacture of drugs used to treat affective processes or diseases that are effective in treating, albeit with side effects, venlafaxine.

EA201070055A 2007-06-26 2008-06-23 N-OXIDES OF VENLAFAXIN AND O-DESMETHYL VENLAFAXIN AS PROCEDURES EA201070055A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94620007P 2007-06-26 2007-06-26
EP07111028 2007-06-26
PCT/EP2008/057939 WO2009000797A1 (en) 2007-06-26 2008-06-23 N-oxides of venlafaxine and o-desmethylvenlafaxine as prodrugs

Publications (1)

Publication Number Publication Date
EA201070055A1 true EA201070055A1 (en) 2010-06-30

Family

ID=39733771

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070055A EA201070055A1 (en) 2007-06-26 2008-06-23 N-OXIDES OF VENLAFAXIN AND O-DESMETHYL VENLAFAXIN AS PROCEDURES

Country Status (7)

Country Link
EP (1) EP2170816A1 (en)
KR (1) KR20100040881A (en)
AU (1) AU2008267273A1 (en)
CA (1) CA2699961A1 (en)
EA (1) EA201070055A1 (en)
IL (1) IL202464A0 (en)
WO (1) WO2009000797A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2961212B1 (en) 2010-06-15 2012-12-21 Commissariat Energie Atomique PROCESS FOR THE PREPARATION OF A COMPOSITE MATERIAL COMPRISING A POLYMERIC MATRIX AND A CHARGE CONSISTING OF INORGANIC ION-EXCHANGING PARTICLES
US11473878B2 (en) 2020-10-28 2022-10-18 Doron LABOCK Arrangement for ballistically protecting a driver or passenger in a civilian vehicle

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4535186A (en) * 1983-04-19 1985-08-13 American Home Products Corporation 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives
US5223541A (en) * 1991-09-13 1993-06-29 Mcneilab, Inc. Tramadol n-oxide material, enantiomers and compositions thereof, and their use
EP1721889A1 (en) * 2005-05-12 2006-11-15 Dishman Pharmaceuticals & Chemicals Ltd. Process for the preparation of phenethylamine derivatives

Also Published As

Publication number Publication date
WO2009000797A1 (en) 2008-12-31
CA2699961A1 (en) 2008-12-31
IL202464A0 (en) 2010-06-30
EP2170816A1 (en) 2010-04-07
KR20100040881A (en) 2010-04-21
AU2008267273A1 (en) 2008-12-31

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