EA201001684A1 - VACCINE AGAINST RABORALITY FOR ORAL IMMUNIZATION OF WILD EMPATHLY ANIMALS AND METHOD FOR ITS OBTAINING - Google Patents
VACCINE AGAINST RABORALITY FOR ORAL IMMUNIZATION OF WILD EMPATHLY ANIMALS AND METHOD FOR ITS OBTAININGInfo
- Publication number
- EA201001684A1 EA201001684A1 EA201001684A EA201001684A EA201001684A1 EA 201001684 A1 EA201001684 A1 EA 201001684A1 EA 201001684 A EA201001684 A EA 201001684A EA 201001684 A EA201001684 A EA 201001684A EA 201001684 A1 EA201001684 A1 EA 201001684A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- strain
- rabies virus
- vaccine
- rabies
- avirulent
- Prior art date
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Fodder In General (AREA)
Abstract
Изобретение относится к области ветеринарной вирусологии, а именно к вакцине против бешенства и способу ее получения. Для повышении эффективности за счет увеличения антигенной и иммуногенной активности и безвредности инактивированной вакцины вакцина против бешенства для оральной иммунизации диких плотоядных животных, включающая вакцинный штамм вируса бешенства, выращенный в перевиваемой культуре клеток, и пищевые и формообразующие компоненты, содержит в качестве вакцинного штамма культуральную жидкость, содержащую авирулентный штамм вируса бешенства с титром инфекционности 6,0-8,5 lg FFU/см, в качестве пищевых и формообразующих компонентов содержит рыбную муку, говяжий жир, парафин или пищевой полимер и неочищенное зерно хлебных злаков, дополнительно содержит маркер - тетрациклин, при определенном соотношении компонентов. В качестве авирулентного штамма вируса бешенства содержится авирулентный штамм вируса бешенства РВ-97 или ERA G333. В качестве неочищенного зерна хлебных злаков содержится зерно пшеницы, ржи, ячменя, овса. В способе получения вакцины против бешенства для оральной иммунизации диких плотоядных животных, включающем вакцинный штамм вируса бешенства, выращенный в перевиваемой культуре клеток, и пищевые и формообразующие компоненты, вакцинный штамм вируса бешенства выращивают в перевиваемых монослойно-суспензионных сублиниях клеток почки новорожденного сирийского хомячка ВНК-21/13-02 или почки сайги, полученную культуральную жидкость, содержащую авирулентный штамм вируса бешенства с титром инфекционности 6,0-8,5 lg FFU/смзамораживают при минус 20-40°С, далее тетрациклин, парафин, неочищенное зерно хлебных злаков, рыбную муку,The invention relates to the field of veterinary Virology, namely to the rabies vaccine and how to obtain it. To increase efficiency by increasing the antigenic and immunogenic activity and safety of an inactivated vaccine, the rabies vaccine for oral immunization of wild carnivorous animals, including the vaccine strain of the rabies virus grown in transplantable cell culture, and nutritional and form-building components, contains as a vaccine strain a culture fluid, containing an avirulent strain of rabies virus with an infectious titer of 6.0-8.5 lg FFU / cm, contains rations as food and formative components Bnaya flour, beef tallow, paraffin or food polymer and unrefined cereal grain, additionally contains a marker - tetracycline, at a certain ratio of components. The avirulent rabies virus strain PB-97 or ERA G333 is contained as an avirulent rabies virus strain. Grain of wheat, rye, barley, oats is contained in the quality of unrefined grain of cereals. In the method of producing rabies vaccines for oral immunization of wild carnivores comprising a vaccine strain rabies virus grown in continuous cell culture, and food and formative components a vaccine strain rabies virus grown in transplanted monolayer-suspension sublines kidney newborn Syrian hamster BHK-21 cells / 13-02 or saiga kidney, obtained culture fluid containing an avirulent strain of rabies virus with an infectious titer of 6.0-8.5 lg FFU / cm frozen by minus 20-40 C, more tetracycline, paraffin, crude grain cereals, fish meal,
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2010144856/15A RU2440139C1 (en) | 2010-11-03 | 2010-11-03 | Anti-rabies vaccine for oral immunisation of wild carnivorous animals and method of its obtaining |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201001684A1 true EA201001684A1 (en) | 2011-08-30 |
| EA015458B1 EA015458B1 (en) | 2011-08-30 |
Family
ID=44544190
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201001684A EA015458B1 (en) | 2010-11-03 | 2010-11-22 | Virus vaccine against rabies for oral immunization in wild carnivores and method for its production |
Country Status (2)
| Country | Link |
|---|---|
| EA (1) | EA015458B1 (en) |
| RU (1) | RU2440139C1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103083654A (en) * | 2012-08-27 | 2013-05-08 | 万里明 | Process for preparing human diploid cell rabies vaccine through Celligen310 bioreactor |
| RU2563542C1 (en) * | 2014-10-30 | 2015-09-20 | Федеральное государственное бюджетное научное учреждение "Всероссийский научно-исследовательский и технологический институт биологической промышленности" | Rabies vaccine for oral immunisation of wild and stray carnivorous animals and method for producing same |
| RU2704970C1 (en) * | 2019-02-18 | 2019-11-01 | Федеральное государственное бюджетное научное учреждение Всероссийский научно-исследовательский и технологический институт биологической промышленности | Bait for oral immunization of wild carnivores against rabies |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4014991A (en) * | 1976-01-23 | 1977-03-29 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Oral rabies immunization of carnivores |
| EP0100752A3 (en) * | 1982-08-04 | 1985-04-17 | Veterinär-Bakteriologisches Institut der Universität Bern | Process for the preparation of a rabies vaccine, holder and means for its administration and process for oral immunisation |
| RU2250781C2 (en) * | 2003-07-10 | 2005-04-27 | ВНИИ ветеринарной вирусологии и микробиологии | Method for manufacturing viral antirabic vaccine for oral immunization i wild carnivores |
| RU2311924C2 (en) * | 2005-12-09 | 2007-12-10 | ГНУ ВНИИ ветеринарной вирусологии и микробиологии | Virus vaccine against rabies for oral immunization in wild carnivores and method for its manufacturing |
| CN101757619A (en) * | 2009-11-11 | 2010-06-30 | 郑州后羿制药有限公司 | Veterinary rabies inactivated vaccine and preparation method thereof |
-
2010
- 2010-11-03 RU RU2010144856/15A patent/RU2440139C1/en not_active IP Right Cessation
- 2010-11-22 EA EA201001684A patent/EA015458B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EA015458B1 (en) | 2011-08-30 |
| RU2440139C1 (en) | 2012-01-20 |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): BY KZ RU |