EA201001596A1 - COMPOUNDS AND COMPOSITIONS AS PROTEINKINASE INHIBITORS - Google Patents
COMPOUNDS AND COMPOSITIONS AS PROTEINKINASE INHIBITORSInfo
- Publication number
- EA201001596A1 EA201001596A1 EA201001596A EA201001596A EA201001596A1 EA 201001596 A1 EA201001596 A1 EA 201001596A1 EA 201001596 A EA201001596 A EA 201001596A EA 201001596 A EA201001596 A EA 201001596A EA 201001596 A1 EA201001596 A1 EA 201001596A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- compositions
- ros
- proteinkinase inhibitors
- proteinkinase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Настоящее изобретение относится к новым производным триазина и пиримидина формул (1) или (2) и к способам применения таких соединений. Например, соединения по изобретению могут использоваться для лечения, облегчения или профилактики состояния, которое связано с ингибированием активности анапластической лимфомной киназы (ALK), онкогена c-ros (ROS), инсулиноподобного фактора роста (IGF-1R) и/или инсулинового рецептора (InsR) или их комбинации.The present invention relates to new derivatives of triazine and pyrimidine of the formulas (1) or (2) and to methods of using such compounds. For example, the compounds of the invention can be used to treat, alleviate or prevent a condition that is associated with inhibition of the activity of anaplastic lymphoma kinase (ALK), c-ros oncogen (ROS), insulin-like growth factor (IGF-1R) and / or insulin receptor (InsR ) or combinations thereof.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4311108P | 2008-04-07 | 2008-04-07 | |
US9588308P | 2008-09-10 | 2008-09-10 | |
PCT/US2009/039380 WO2009126514A1 (en) | 2008-04-07 | 2009-04-03 | Compounds and compositions as kinase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201001596A1 true EA201001596A1 (en) | 2011-04-29 |
EA018484B1 EA018484B1 (en) | 2013-08-30 |
Family
ID=40786670
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201001596A EA018484B1 (en) | 2008-04-07 | 2009-04-03 | Compounds and compositions as kinase inhibitors |
Country Status (13)
Country | Link |
---|---|
US (1) | US8518931B2 (en) |
EP (1) | EP2271645A1 (en) |
JP (1) | JP5214799B2 (en) |
KR (1) | KR20110002080A (en) |
CN (1) | CN102056925A (en) |
AR (1) | AR071300A1 (en) |
AU (1) | AU2009233963B2 (en) |
BR (1) | BRPI0910979A2 (en) |
CA (1) | CA2720944C (en) |
EA (1) | EA018484B1 (en) |
MX (1) | MX2010011069A (en) |
UY (1) | UY31750A (en) |
WO (1) | WO2009126514A1 (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI389893B (en) | 2007-07-06 | 2013-03-21 | Astellas Pharma Inc | Di (arylamino) ary1 compound |
US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
SI2300013T1 (en) | 2008-05-21 | 2018-03-30 | Adriad Pharmacaceuticals, Inc. | Phosphorous derivatives as kinase inhibitors |
MX2011011875A (en) | 2009-05-08 | 2011-12-08 | Astellas Pharma Inc | Diamino heterocyclic carboxamide compound. |
WO2012097478A1 (en) * | 2011-01-21 | 2012-07-26 | Abbott Laboratories | Bicyclic carboxamide inhibitors of kinases |
EP2704572B1 (en) | 2011-05-04 | 2015-12-30 | Ariad Pharmaceuticals, Inc. | Compounds for inhibiting cell proliferation in egfr-driven cancers |
US20150166591A1 (en) | 2012-05-05 | 2015-06-18 | Ariad Pharmaceuticals, Inc. | Methods and compositions for raf kinase mediated diseases |
SG11201408816QA (en) | 2012-07-03 | 2015-03-30 | Aurigene Discovery Tech Ltd | 3-(PYRAZOLYL)-1H-PYRROLO[2,3-b]PYRIDINE DERIVATIVES AS KINASE INHIBITORS |
AU2013344049B2 (en) * | 2012-11-06 | 2017-12-21 | Fochon Pharmaceuticals, Ltd. | ALK kinase inhibitors |
US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
CN103570728B (en) * | 2013-11-12 | 2015-12-30 | 山东大学 | Also [1,5-a] pyridine derivatives and preparation method thereof and the application of a kind of substituted pyrazolecarboxylic |
ES2715676T3 (en) * | 2014-03-27 | 2019-06-05 | Janssen Pharmaceutica Nv | Substituted 4,5,6,7-tetrahydro-pyrazolo [1,5-a] pyrazine derivatives and 5,6,7,8-tetrahydro-4h-pyrazolo [1,5-a] [1,4] diazepine as ros1 inhibitors |
WO2016130920A2 (en) * | 2015-02-13 | 2016-08-18 | Dana-Farber Cancer Institute, Inc. | Lrrk2 inhibitors and methods of making and using the same |
US11046698B2 (en) | 2017-07-28 | 2021-06-29 | Nimbus Lakshmi, Inc. | TYK2 inhibitors and uses thereof |
CN110483526B (en) * | 2019-09-09 | 2021-10-01 | 辽宁大学 | Pyrazolo [1,5-a ] pyrimidine derivative containing aryl hydrazone structure and application thereof |
GB201915618D0 (en) | 2019-10-28 | 2019-12-11 | Univ Oslo | ALK inhibitors for treatment of ALK-negative cancer and antibody-mediated diseases |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7406641A (en) | 1973-05-22 | 1974-11-26 | ||
JP2004516297A (en) | 2000-12-20 | 2004-06-03 | ソシエテ・ド・コンセイユ・ド・ルシエルシエ・エ・ダアツプリカーション・シヤンテイフイツク・(エス.セー.エール.アー.エス) | Inhibitors of cyclin dependent kinase (CDK) and glycogen synthase kinase-3 (GSK-3) |
FR2842809A1 (en) * | 2002-07-26 | 2004-01-30 | Greenpharma Sas | NOVEL SUBSTITUTED PYRAZOLO [1,5-a] -1,3,5-TRIAZINES AND THEIR ANALOGUES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, USE AS A MEDICAMENT AND METHODS FOR THEIR PREPARATION |
EP1534712B1 (en) * | 2002-09-04 | 2007-05-16 | Schering Corporation | Pyrazolo[1,5-a]pyrimidine compounds as cyclin dependent kinase inhibitors |
EP1599482A4 (en) * | 2003-02-28 | 2008-10-01 | Teijin Pharma Ltd | Pyrazolo 1,5-a pyrimidine derivatives |
GB0305559D0 (en) * | 2003-03-11 | 2003-04-16 | Teijin Ltd | Compounds |
EP1608652A1 (en) * | 2003-03-31 | 2005-12-28 | Vernalis (Cambridge) Limited | Pyrazolopyrimidine compounds and their use in medicine |
WO2005035516A1 (en) * | 2003-10-10 | 2005-04-21 | Ono Pharmaceutical Co., Ltd. | Novel fused heterocyclic compound and use thereof |
AR047969A1 (en) * | 2004-02-25 | 2006-03-15 | Schering Corp | PIRAZOLOTRIAZINAS AS QUINASA INHIBITORS |
JP2006160628A (en) | 2004-12-03 | 2006-06-22 | Ishihara Sangyo Kaisha Ltd | COMPOSITION FOR TREATING OR PREVENTING DISEASE REQUIRING ADMINISTRATION OF ADENOSINE A2a RECEPTOR AGONIST |
US7741318B2 (en) * | 2004-12-21 | 2010-06-22 | Schering Corporation | Pyrazolo [1,5-A]pyrimidine adenosine A2a receptor antagonists |
US7723336B2 (en) * | 2005-09-22 | 2010-05-25 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
US7517882B2 (en) * | 2006-09-18 | 2009-04-14 | Polaris Group | Protein kinase inhibitors |
WO2008057402A2 (en) | 2006-11-02 | 2008-05-15 | Cytovia, Inc. | N-aryl-isoxazolopyrimidin-4-amines and related compounds as activators of caspases and inducers of apoptosis and the use thereof |
-
2009
- 2009-04-03 AU AU2009233963A patent/AU2009233963B2/en not_active Ceased
- 2009-04-03 EP EP09731237A patent/EP2271645A1/en not_active Withdrawn
- 2009-04-03 KR KR1020107024934A patent/KR20110002080A/en not_active Application Discontinuation
- 2009-04-03 WO PCT/US2009/039380 patent/WO2009126514A1/en active Application Filing
- 2009-04-03 US US12/936,193 patent/US8518931B2/en not_active Expired - Fee Related
- 2009-04-03 CA CA2720944A patent/CA2720944C/en not_active Expired - Fee Related
- 2009-04-03 BR BRPI0910979A patent/BRPI0910979A2/en not_active IP Right Cessation
- 2009-04-03 JP JP2011504085A patent/JP5214799B2/en not_active Expired - Fee Related
- 2009-04-03 EA EA201001596A patent/EA018484B1/en not_active IP Right Cessation
- 2009-04-03 CN CN2009801210269A patent/CN102056925A/en active Pending
- 2009-04-03 UY UY0001031750A patent/UY31750A/en not_active Application Discontinuation
- 2009-04-03 MX MX2010011069A patent/MX2010011069A/en not_active Application Discontinuation
- 2009-04-07 AR ARP090101228A patent/AR071300A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
AR071300A1 (en) | 2010-06-09 |
US8518931B2 (en) | 2013-08-27 |
CA2720944A1 (en) | 2009-10-15 |
UY31750A (en) | 2009-12-14 |
US20110190264A1 (en) | 2011-08-04 |
EP2271645A1 (en) | 2011-01-12 |
AU2009233963B2 (en) | 2011-10-06 |
KR20110002080A (en) | 2011-01-06 |
JP2011516554A (en) | 2011-05-26 |
CN102056925A (en) | 2011-05-11 |
JP5214799B2 (en) | 2013-06-19 |
WO2009126514A1 (en) | 2009-10-15 |
MX2010011069A (en) | 2010-11-12 |
BRPI0910979A2 (en) | 2016-01-05 |
AU2009233963A1 (en) | 2009-10-15 |
CA2720944C (en) | 2012-12-18 |
EA018484B1 (en) | 2013-08-30 |
WO2009126514A8 (en) | 2010-10-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MC4A | Revocation of a eurasian patent under opposition procedure |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |