EA200801417A1 - CONNECTION OF BICYCLIC CINNAMIDE - Google Patents
CONNECTION OF BICYCLIC CINNAMIDEInfo
- Publication number
- EA200801417A1 EA200801417A1 EA200801417A EA200801417A EA200801417A1 EA 200801417 A1 EA200801417 A1 EA 200801417A1 EA 200801417 A EA200801417 A EA 200801417A EA 200801417 A EA200801417 A EA 200801417A EA 200801417 A1 EA200801417 A1 EA 200801417A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- group
- optionally substituted
- compound
- connection
- bicyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
Бициклическое соединение циннамида, представленное общей формулой (I)гдеявляется одинарной или двойной связью; Arявляется фенильной группой или пиридинильной группой, необязательно замещенной от одного до трех заместителей; Rи Rкаждый является C1-6 алкильной группой, гидроксильной группой и т.д.; Zявляется необязательно замещенной метиленовой группой или виниленовой группой, атомом кислорода или иминогруппой, необязательно замещенной C1-6 алкильной группой или C1-6 ацильной группой; и p, q и r каждый равен целому числу от 0 до 2. Соединение действует на снижение Aβ4O и Aβ42. Поэтому соединение особенно полезно в качестве профилактического или лекарственного средства для нейродегенеративных заболеваний, причиной которых является таких как болезнь Альцгеймера или синдром Дауна.The bicyclic cinnamide compound represented by the general formula (I) wherein is a single or double bond; Ar is a phenyl group or a pyridinyl group optionally substituted with one to three substituents; R and R are each a C1-6 alkyl group, a hydroxyl group, etc .; Z is an optionally substituted methylene group or a vinylene group, an oxygen atom or an imino group, an optionally substituted C1-6 alkyl group or a C1-6 acyl group; and p, q and r are each an integer from 0 to 2. The compound acts to reduce Aβ4O and Aβ42. Therefore, the compound is particularly useful as a prophylactic or drug for neurodegenerative diseases caused by such as Alzheimer's disease or Down syndrome.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005337963 | 2005-11-24 | ||
JP2006205538 | 2006-07-28 | ||
PCT/JP2006/321877 WO2007060821A1 (en) | 2005-11-24 | 2006-11-01 | Bicyclic cinnamide compound |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200801417A1 true EA200801417A1 (en) | 2009-02-27 |
EA014427B1 EA014427B1 (en) | 2010-12-30 |
Family
ID=38067057
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200801417A EA014427B1 (en) | 2005-11-24 | 2006-11-01 | Bicyclic cinnamide compound |
Country Status (26)
Country | Link |
---|---|
US (1) | US8048878B2 (en) |
EP (1) | EP1953158B1 (en) |
JP (1) | JP5178203B2 (en) |
KR (1) | KR101296239B1 (en) |
AR (1) | AR057915A1 (en) |
AU (1) | AU2006317468B2 (en) |
BR (1) | BRPI0618890A2 (en) |
CA (1) | CA2629512C (en) |
CR (1) | CR9983A (en) |
EA (1) | EA014427B1 (en) |
EC (1) | ECSP088466A (en) |
ES (1) | ES2394364T3 (en) |
GE (1) | GEP20115172B (en) |
HK (1) | HK1122806A1 (en) |
HN (1) | HN2008000792A (en) |
MA (1) | MA29968B1 (en) |
ME (1) | ME00040B (en) |
MY (1) | MY144596A (en) |
NO (1) | NO20082805L (en) |
NZ (1) | NZ568422A (en) |
PE (1) | PE20071029A1 (en) |
PL (1) | PL1953158T3 (en) |
RS (1) | RS20080242A (en) |
SA (1) | SA06270432B1 (en) |
TW (1) | TWI370130B (en) |
WO (1) | WO2007060821A1 (en) |
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TWI335816B (en) * | 2004-05-26 | 2011-01-11 | Eisai R&D Man Co Ltd | Cinnamide compound |
EP1808432B1 (en) | 2004-10-26 | 2010-02-24 | Eisai R&D Management Co., Ltd. | Amorphous form of cinnamide compound |
TWI370130B (en) | 2005-11-24 | 2012-08-11 | Eisai R&D Man Co Ltd | Two cyclic cinnamide compound |
KR20080069221A (en) | 2005-11-24 | 2008-07-25 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | Morpholine type cinnamide compound |
US7482345B2 (en) * | 2005-12-05 | 2009-01-27 | Meng-Hsin Chen | P38 kinase inhibiting agents |
TWI378091B (en) | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
SA07280403B1 (en) | 2006-07-28 | 2010-12-01 | إيساي أر أند دي منجمنت كو. ليمتد | Quaternary salt of cinnamide compound |
TW200848054A (en) | 2007-02-28 | 2008-12-16 | Eisai R&D Man Co Ltd | Two cyclic oxomorpholine derivatives |
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-
2006
- 2006-10-27 TW TW095139718A patent/TWI370130B/en not_active IP Right Cessation
- 2006-11-01 KR KR1020087014992A patent/KR101296239B1/en not_active IP Right Cessation
- 2006-11-01 CA CA2629512A patent/CA2629512C/en not_active Expired - Fee Related
- 2006-11-01 AU AU2006317468A patent/AU2006317468B2/en not_active Ceased
- 2006-11-01 ES ES06822806T patent/ES2394364T3/en active Active
- 2006-11-01 MY MYPI20081628A patent/MY144596A/en unknown
- 2006-11-01 EA EA200801417A patent/EA014427B1/en not_active IP Right Cessation
- 2006-11-01 WO PCT/JP2006/321877 patent/WO2007060821A1/en active Application Filing
- 2006-11-01 GE GEAP200610709A patent/GEP20115172B/en unknown
- 2006-11-01 ME MEP-2008-49A patent/ME00040B/en unknown
- 2006-11-01 PL PL06822806T patent/PL1953158T3/en unknown
- 2006-11-01 JP JP2007546389A patent/JP5178203B2/en not_active Expired - Fee Related
- 2006-11-01 RS RSP-2008/0242A patent/RS20080242A/en unknown
- 2006-11-01 NZ NZ568422A patent/NZ568422A/en not_active IP Right Cessation
- 2006-11-01 EP EP06822806A patent/EP1953158B1/en active Active
- 2006-11-01 BR BRPI0618890-7A patent/BRPI0618890A2/en not_active IP Right Cessation
- 2006-11-20 AR ARP060105075A patent/AR057915A1/en not_active Application Discontinuation
- 2006-11-21 PE PE2006001479A patent/PE20071029A1/en not_active Application Discontinuation
- 2006-11-22 SA SA6270432A patent/SA06270432B1/en unknown
-
2008
- 2008-05-16 CR CR9983A patent/CR9983A/en not_active Application Discontinuation
- 2008-05-20 MA MA30952A patent/MA29968B1/en unknown
- 2008-05-22 EC EC2008008466A patent/ECSP088466A/en unknown
- 2008-05-23 HN HN2008000792A patent/HN2008000792A/en unknown
- 2008-06-19 NO NO20082805A patent/NO20082805L/en not_active Application Discontinuation
- 2008-12-29 HK HK08114015.4A patent/HK1122806A1/en not_active IP Right Cessation
-
2009
- 2009-03-13 US US12/403,565 patent/US8048878B2/en not_active Expired - Fee Related
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