EA200702027A1 - DERMATOLOGICAL COMPOSITIONS AND SALTS FOR THE TREATMENT OF DERMATOLOGICAL DISEASES - Google Patents

DERMATOLOGICAL COMPOSITIONS AND SALTS FOR THE TREATMENT OF DERMATOLOGICAL DISEASES

Info

Publication number
EA200702027A1
EA200702027A1 EA200702027A EA200702027A EA200702027A1 EA 200702027 A1 EA200702027 A1 EA 200702027A1 EA 200702027 A EA200702027 A EA 200702027A EA 200702027 A EA200702027 A EA 200702027A EA 200702027 A1 EA200702027 A1 EA 200702027A1
Authority
EA
Eurasian Patent Office
Prior art keywords
dermatological
treatment
salts
compositions
diseases
Prior art date
Application number
EA200702027A
Other languages
Russian (ru)
Inventor
Мортен Слот Вэйднер
Original Assignee
Астион Фарма А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Астион Фарма А/С filed Critical Астион Фарма А/С
Publication of EA200702027A1 publication Critical patent/EA200702027A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicinal Preparation (AREA)

Abstract

Изобретение относится к дерматологическим композициям оксапрозина или близкородственного соединения соответственно адаптированного для лечения дерматологического заболевания, где по крайней мере два фермента выбраны из протеин тирозин киназы Syk, протеин тирозин киназы ZAP- 70 и фосфодиэстеразы IV, играют роль в опосредовании дерматологического заболевания. Изобретение также включает дерматологическую композицию для лечения зуда.The invention relates to the dermatological compositions of oxaprozin or a closely related compound, respectively, adapted for the treatment of dermatological disease, where at least two enzymes are selected from Syk protein tyrosine kinase, protein tyrosine kinase ZAP- 70 and phosphodiesterase IV, play a role in mediating a dermatological disease. The invention also includes a dermatological composition for treating pruritus.

EA200702027A 2005-03-30 2006-03-30 DERMATOLOGICAL COMPOSITIONS AND SALTS FOR THE TREATMENT OF DERMATOLOGICAL DISEASES EA200702027A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
DKPA200500437 2005-03-30
DKPA200500438 2005-03-30
US69477405P 2005-06-27 2005-06-27
DKPA200500948 2005-06-27
DKPA200500949 2005-06-27
US69504005P 2005-06-28 2005-06-28
PCT/DK2006/000181 WO2006102900A1 (en) 2005-03-30 2006-03-30 Dermatological compositions and salts for the treatment of dermatological diseases

Publications (1)

Publication Number Publication Date
EA200702027A1 true EA200702027A1 (en) 2008-02-28

Family

ID=36215671

Family Applications (3)

Application Number Title Priority Date Filing Date
EA200702026A EA200702026A1 (en) 2005-03-30 2006-03-30 TREATMENT OR PREVENTION OF ZUD
EA200702023A EA200702023A1 (en) 2005-03-30 2006-03-30 Eczema treatment
EA200702027A EA200702027A1 (en) 2005-03-30 2006-03-30 DERMATOLOGICAL COMPOSITIONS AND SALTS FOR THE TREATMENT OF DERMATOLOGICAL DISEASES

Family Applications Before (2)

Application Number Title Priority Date Filing Date
EA200702026A EA200702026A1 (en) 2005-03-30 2006-03-30 TREATMENT OR PREVENTION OF ZUD
EA200702023A EA200702023A1 (en) 2005-03-30 2006-03-30 Eczema treatment

Country Status (12)

Country Link
EP (3) EP1707201A1 (en)
JP (3) JP2008534527A (en)
KR (3) KR20080005525A (en)
AU (3) AU2006228869A1 (en)
BR (3) BRPI0609653A2 (en)
CA (3) CA2605121A1 (en)
EA (3) EA200702026A1 (en)
EC (3) ECSP077843A (en)
IL (3) IL186020A0 (en)
MX (3) MX2007012052A (en)
NO (3) NO20075199L (en)
WO (3) WO2006102900A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0821537D0 (en) * 2008-11-25 2008-12-31 Union Life Sciences Ltd Therapeutic target
WO2017045081A1 (en) * 2015-09-18 2017-03-23 Delivra Inc. Transdermal formulations for delivery of propionic and acetic acid nsaids, and their use in the treatment of nsaid-responsive diseases and conditions
EP3496681A4 (en) 2016-08-08 2020-07-22 Avedro, Inc. Systems and methods for cross-linking treatments of an eye
JP7199096B2 (en) 2016-10-25 2023-01-05 ティキュア リミテッド FABP4 as a therapeutic target in skin diseases
US20210093637A1 (en) * 2017-12-07 2021-04-01 Dermavant Sciences GmbH Topical ointment formulations of pde-4 inhibitor and their use in treating skin conditions
RU2685436C1 (en) * 2018-06-22 2019-04-18 ЗАО "ФармФирма "Сотекс" Transdermal preparation for treatment and prevention of diseases of joints and soft tissues
JP2020100575A (en) * 2018-12-20 2020-07-02 小林製薬株式会社 External composition for skin

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE32084B1 (en) * 1967-06-07 1973-04-04 Wyeth John & Brother Ltd Thiazole derivatives
US3578671A (en) 1967-11-06 1971-05-11 Wyeth John & Brother Ltd Oxazoles
IE52909B1 (en) * 1981-04-28 1988-04-13 Wyeth John & Brother Ltd Oxazole derivatives
US4659728A (en) * 1985-02-25 1987-04-21 American Home Products Corporation Hydroxy substituted 4,5-diphenyl-2-oxazole propanoic acid
EP0270316A3 (en) * 1986-12-04 1989-12-06 Pfizer Inc. Topical compositions comprising 1-substituted imidazoles and nsaids for treatment of acne
US5380738A (en) * 1993-05-21 1995-01-10 Monsanto Company 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents
US6090834A (en) * 1993-05-21 2000-07-18 G.D. Searle & Co. Substituted oxazoles for the treatment of inflammation
EP0724438A1 (en) 1993-10-20 1996-08-07 The Boots Company PLC Ibuprofen and flurbiprofen as anti-pruritic agents
JPH07316075A (en) 1994-05-26 1995-12-05 Pola Chem Ind Inc External preparation for skin
GB9606429D0 (en) 1996-03-27 1996-06-05 Boots Co Plc Pharmaceutical compositions
NZ332861A (en) * 1996-05-20 2000-08-25 G Potassium, sodium and tris oxaprozin salt pharmaceutical formulations
US5976566A (en) * 1997-08-29 1999-11-02 Macrochem Corporation Non-steroidal antiinflammtory drug formulations for topical application to the skin
IL142037A0 (en) * 2001-03-15 2002-03-10 Agis Ind 1983 Ltd Pharmaceutical compositions containing a non-steroidal anti-inflammatory drug
WO2005009342A2 (en) 2003-07-16 2005-02-03 Pharmacia Corporation Method for the treatment or prevention of dermatological disorders with a cyclooxygenase-2 inhibitor alone and in combination with a dermatological treatment agent and compositions therewith
US20050232957A1 (en) 2004-04-14 2005-10-20 Katz Kenneth A Compositions and methods for moisturizing skin

Also Published As

Publication number Publication date
CA2603300A1 (en) 2006-10-05
ECSP077845A (en) 2008-02-20
EP1707199A1 (en) 2006-10-04
BRPI0607648A2 (en) 2009-09-22
EA200702023A1 (en) 2008-04-28
CA2605121A1 (en) 2006-10-05
MX2007012050A (en) 2008-03-11
WO2006102900A1 (en) 2006-10-05
WO2006102898A3 (en) 2006-12-28
WO2006102899A2 (en) 2006-10-05
BRPI0609535A2 (en) 2010-04-13
IL186022A0 (en) 2008-02-09
EP1707200A1 (en) 2006-10-04
NO20075227L (en) 2007-12-09
MX2007012051A (en) 2008-02-22
JP2008534526A (en) 2008-08-28
KR20080005526A (en) 2008-01-14
NO20075199L (en) 2008-01-02
ECSP077846A (en) 2008-02-20
CA2603297A1 (en) 2006-10-05
AU2006228871A1 (en) 2006-10-05
MX2007012052A (en) 2008-02-22
KR20080005525A (en) 2008-01-14
EP1707201A1 (en) 2006-10-04
IL186020A0 (en) 2008-01-20
NO20075218L (en) 2007-12-27
KR20080011280A (en) 2008-02-01
BRPI0609653A2 (en) 2010-04-20
ECSP077843A (en) 2008-02-20
AU2006228869A1 (en) 2006-10-05
JP2008534527A (en) 2008-08-28
IL186021A0 (en) 2008-02-09
WO2006102898A2 (en) 2006-10-05
AU2006228870A1 (en) 2006-10-05
JP2008534528A (en) 2008-08-28
EA200702026A1 (en) 2008-04-28
WO2006102899A3 (en) 2006-12-28

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