EA200601641A1 - CRYSTAL COMPOSITION CONTAINING ESCYTAL PREMAX OXALATE - Google Patents
CRYSTAL COMPOSITION CONTAINING ESCYTAL PREMAX OXALATEInfo
- Publication number
- EA200601641A1 EA200601641A1 EA200601641A EA200601641A EA200601641A1 EA 200601641 A1 EA200601641 A1 EA 200601641A1 EA 200601641 A EA200601641 A EA 200601641A EA 200601641 A EA200601641 A EA 200601641A EA 200601641 A1 EA200601641 A1 EA 200601641A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- oxalate
- particles
- escytal
- premax
- composition containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
В настоящем изобретении описаны кристаллические частицы оксалата эсциталопрама, имеющие широкое распределение размера частиц или содержащие 0,01% (мас./мас.) Z-4-(4-диметиламино-1-(4-фторфенил)бут-1-енил)-3-гидроксиметилбензонитрила, где указанные частицы пригодны для применения в непосредственном прессовании. Кроме того, в изобретении описана новая фармацевтическая единичная дозированная форма, содержащая такие кристаллические частицы оксалата эсциталопрама, а также способы получения таких кристаллических частиц оксалата эсциталопрама. Наконец, изобретение относится к способу уменьшения количества гидроксилсодержащих примесей в растворе циталопрама и эсциталопрама.The present invention describes crystalline escitalopram oxalate particles having a wide particle size distribution or containing 0.01% (w / w) Z-4- (4-dimethylamino-1- (4-fluorophenyl) but-1-enyl) - 3-hydroxymethylbenzonitrile, where these particles are suitable for use in direct compression. In addition, the invention describes a new pharmaceutical unit dosage form containing such crystalline particles of escitalopram oxalate, as well as methods for producing such crystalline particles of escitalopram oxalate. Finally, the invention relates to a method for reducing the amount of hydroxyl-containing impurities in a solution of citalopram and escitalopram.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55090904P | 2004-03-05 | 2004-03-05 | |
DKPA200400382 | 2004-03-05 | ||
PCT/DK2005/000115 WO2005084643A1 (en) | 2004-03-05 | 2005-02-21 | Crystalline composition containing escitalopram oxalate |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200601641A1 true EA200601641A1 (en) | 2006-12-29 |
Family
ID=34921251
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200601641A EA200601641A1 (en) | 2004-03-05 | 2005-02-21 | CRYSTAL COMPOSITION CONTAINING ESCYTAL PREMAX OXALATE |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1732514A1 (en) |
JP (1) | JP2007526262A (en) |
AU (1) | AU2005218713B2 (en) |
BR (1) | BRPI0508266A (en) |
CA (1) | CA2558198A1 (en) |
EA (1) | EA200601641A1 (en) |
NO (1) | NO20064499L (en) |
NZ (1) | NZ549100A (en) |
WO (1) | WO2005084643A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI347942B (en) * | 2005-06-22 | 2011-09-01 | Lundbeck & Co As H | Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base |
CA2672925A1 (en) * | 2006-10-20 | 2008-04-24 | Ratiopharm Gmbh | Escitalopram and solid pharmaceutical composition comprising the same |
EP2116231A1 (en) * | 2008-05-07 | 2009-11-11 | Hexal Ag | Granulate comprising escitalopram oxalate |
JP2018016569A (en) * | 2016-07-26 | 2018-02-01 | 株式会社トクヤマ | Production method of (1s)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile oxalate |
JP6554245B1 (en) * | 2019-01-31 | 2019-07-31 | 第一工業製薬株式会社 | 2,2'-bis (2-hydroxyethoxy) -1,1'-binaphthalene powder |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8814057D0 (en) * | 1988-06-14 | 1988-07-20 | Lundbeck & Co As H | New enantiomers & their isolation |
MXPA03008777A (en) * | 2001-05-01 | 2004-02-12 | Lundbeck & Co As H | The use of enantiomeric pure escitalopram. |
AR034612A1 (en) * | 2001-06-25 | 2004-03-03 | Lundbeck & Co As H | PROCESS FOR THE PREPARATION OF RACEMIC CITALOPRAM AND / OR OF THE S- OR R-CITALOPRAM THROUGH THE SEPARATION OF A MIXING OF R- AND S-CITALOPRAM |
KR20040028947A (en) * | 2001-07-31 | 2004-04-03 | 하. 룬트벡 아크티에 셀스카브 | Crystalline composition containing escitalopram |
PE20040991A1 (en) * | 2002-08-12 | 2004-12-27 | Lundbeck & Co As H | SEPARATION OF INTERMEDIARIES FOR THE PREPARATION OF ESCITALOPRAM |
WO2004056791A1 (en) * | 2002-12-23 | 2004-07-08 | H. Lundbeck A/S | Escitalopram hydrobromide and a method for the preparation thereof |
AU2003223105A1 (en) * | 2003-03-24 | 2004-10-18 | Hetero Drugs Limited | Novel crystalline forms of (s)-citalopram oxalate |
-
2005
- 2005-02-21 NZ NZ549100A patent/NZ549100A/en not_active Application Discontinuation
- 2005-02-21 JP JP2007501117A patent/JP2007526262A/en active Pending
- 2005-02-21 EP EP05706777A patent/EP1732514A1/en not_active Withdrawn
- 2005-02-21 BR BRPI0508266-8A patent/BRPI0508266A/en not_active IP Right Cessation
- 2005-02-21 CA CA002558198A patent/CA2558198A1/en not_active Abandoned
- 2005-02-21 AU AU2005218713A patent/AU2005218713B2/en not_active Withdrawn - After Issue
- 2005-02-21 WO PCT/DK2005/000115 patent/WO2005084643A1/en active Application Filing
- 2005-02-21 EA EA200601641A patent/EA200601641A1/en unknown
-
2006
- 2006-10-04 NO NO20064499A patent/NO20064499L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU2005218713B2 (en) | 2009-11-19 |
NO20064499L (en) | 2006-12-04 |
NZ549100A (en) | 2010-02-26 |
CA2558198A1 (en) | 2005-09-15 |
BRPI0508266A (en) | 2007-07-31 |
JP2007526262A (en) | 2007-09-13 |
WO2005084643A1 (en) | 2005-09-15 |
AU2005218713A1 (en) | 2005-09-15 |
EP1732514A1 (en) | 2006-12-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0206164A (en) | Escitalopram oxalate crystalline particles, method for the production of escitalopram oxalate crystalline particles, and solid unit dosage form | |
TW200612892A (en) | Novel compounds | |
TW200407305A (en) | Novel compounds | |
TW200510301A (en) | Novel compounds | |
TW200510303A (en) | Novel compounds | |
MX2007013065A (en) | Dihydrobenzofuran derivatives and uses thereof. | |
MXPA04003858A (en) | Mch antagonists for the treatment of obesity. | |
MY142029A (en) | Phenoxyacetic acid derivatives | |
EA200701123A1 (en) | METHOD OF CLEANING TRANS - (-) - Δ-TETRAHYDROCANNABINOL AND TRANS - (+) - Δ-TETRAHYDROCANNOBINOL | |
MA33044B1 (en) | PHARMACEUTICAL COMPOSITION CONTAINING GLUCOPYRANOSYL DIPHENYLMETHANE DERIVATIVES, ITS GALENIC DOSAGE FORM, PREPARATION METHOD AND USES FOR ENHANCED GLYCEMIC REGULATION IN PATIENT | |
RU2011117019A (en) | COMPOSITIONS FOR CARE OF THE ORAL CAVITY CONTAINING SPHERICAL PARTICLES OF AMORPHIC QUARTZ | |
SE0203713D0 (en) | Novel compounds | |
MXPA05007182A (en) | Complexes of protein crystals and ionic polymers. | |
WO2004108133A3 (en) | Modulators of vr1 receptor | |
MXPA04004464A (en) | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease. | |
IL181700A0 (en) | Quinazoline derivatives and pharmaceutical compositions containing the same | |
MX2007005710A (en) | Hydroxybenzoate salts of metanicotine compounds. | |
TW200502221A (en) | Novel lactams and uses thereof | |
EA200601641A1 (en) | CRYSTAL COMPOSITION CONTAINING ESCYTAL PREMAX OXALATE | |
SG155046A1 (en) | Process for modifying drug crystal formation | |
HK1079526A1 (en) | A novel pyrazine compound and its use in the manufacture of a medicament for treating diseases related to serotonin | |
MY141528A (en) | Anilinopyrazole derivatives useful for the treatment of diabetes | |
EP1423414A4 (en) | Novel depsipeptides and process for preparing same | |
HK1121670A1 (en) | Preparation and composition of inter-alpha inhibitor proteins from human plasma for therapeutic use | |
NO20053673L (en) | New anticonvulsant derivatives salts |