EA200500800A1 - QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS - Google Patents

Abstract

The present invention relates to the use of a compound for the manufacture of a medicament for the treatment of a bacterial infection, where said compound is a compound of the pharmaceutically acceptable acid or base addition salt, its stereochemically isomeric form or its N-oxide form, where R is hydrogen, halogen, polyhaloalkyl C1-6 alkyl, Ar or Het; p is an integer equal to 1 or 2; R 1 is C 1-6 alkyloxy, C 1-6 alkyloxy C 1-6 alkyloxy or C 1-6 alkylthio; R4 is Ar, Het or Het; R1 and R4 are each independently hydrogen, C1-6 alkyl or benzyl; or R together with the atoms N, to which they are attached may form a radical selected from the group of pyrrolidinyl, 2-pyrrolinyl, 3-pyrrolinyl, pyrrolyl, imidazolidinyl, pyrazolidinyl, 2-imidazolinyl, 2-pyrazolinyl, imidazolyl, pyrazolyl, triazolyl, piperidinyl , pyridinyl, piperazinyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl, morpholinyl and thiomorpholinyl, each of these rings can be optionally substituted by C1-6alkyl, halogen, polyhaloxy4alkyl, hydroxy, hydroxy C1-6alkyloxy, amino, monocyan or polyacetate, polyhydroxyalkyl, hydroxy, hydroxy C1-6 l) amino, alkylthio, SalkiloksiSalkilom, SalkiltioSalkilom or pyrimidinyl; R 1 is hydrogen, halogen, polyhaloalkyl, C1-6 alkyl, C1-6 alkyloxy, C1-6 alkylthio or two vicinal radicals R3 can be taken together to form a bivalent radical of the formula -CH = CH-CH = CH-; r is an integer equal to 1 or 2; R4 is hydrogen, C1-6 alkyl, Ar, Het or Het; provided that the bacterial infection is other than mycobacterial infection.