EA200400716A1 - 3- (IMIDAZOLYL) -2-ALCOXYPROPIONIC ACIDS AS TAFIA INHIBITORS (THROMBIN-ACTIVATED FIBRINOLYSIS INHIBITOR) - Google Patents
3- (IMIDAZOLYL) -2-ALCOXYPROPIONIC ACIDS AS TAFIA INHIBITORS (THROMBIN-ACTIVATED FIBRINOLYSIS INHIBITOR)Info
- Publication number
- EA200400716A1 EA200400716A1 EA200400716A EA200400716A EA200400716A1 EA 200400716 A1 EA200400716 A1 EA 200400716A1 EA 200400716 A EA200400716 A EA 200400716A EA 200400716 A EA200400716 A EA 200400716A EA 200400716 A1 EA200400716 A1 EA 200400716A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alcoxypropionic
- thrombin
- imidazolyl
- acids
- fibrinolysis inhibitor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Соединения формулы (I), где n равно 0-3, Rпредставляет собой возможно замещенный Cалкил, Cалкенил или Cалкинил, гетероцикл, ароматический гетероцикл, арил или водород, а R, R, R, R, R, R, Rи R, каждый независимо, выбран из водорода и возможно замещенного Cалкила или Rи Rпредставляют собой алкиленовую цепь, являются новыми. Они полезны при лечении тромботических состояний и других патологий, связанных с отложением фибрина.Международная заявка была опубликована вместе с отчетом о международном поиске.The compounds of formula (I), where n is 0-3, R 1 is a possibly substituted C 1-6 alkyl, C 1-6 alkenyl or C 1-6 alkynyl, a heterocycle, an aromatic heterocycle, aryl or hydrogen, and R, R, R, R, R, R, R and R each independently is selected from hydrogen and optionally substituted C 1-6 alkyl or R 8 and R 12 represent an alkylene chain are new. They are useful in the treatment of thrombotic conditions and other pathologies associated with fibrin deposition. The international application was published along with an international search report.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0201389A GB0201389D0 (en) | 2002-01-22 | 2002-01-22 | 3-(imidazolyl)-2-alkoxypropanoic acids |
| GB0202027A GB0202027D0 (en) | 2002-01-29 | 2002-01-29 | 3-(imidazolyl)-2-alkoxypropanoic acids |
| PCT/IB2003/000060 WO2003061652A1 (en) | 2002-01-22 | 2003-01-10 | 3-(imidazolyl)-2-alkoxypropanoic acids as tafia inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA200400716A1 true EA200400716A1 (en) | 2004-12-30 |
Family
ID=27614792
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200400716A EA200400716A1 (en) | 2002-01-22 | 2003-01-10 | 3- (IMIDAZOLYL) -2-ALCOXYPROPIONIC ACIDS AS TAFIA INHIBITORS (THROMBIN-ACTIVATED FIBRINOLYSIS INHIBITOR) |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP1467731A1 (en) |
| JP (1) | JP2005520811A (en) |
| KR (1) | KR20040077775A (en) |
| CN (1) | CN1620291A (en) |
| AP (1) | AP2004003084A0 (en) |
| AR (1) | AR038197A1 (en) |
| BR (1) | BR0307016A (en) |
| CA (1) | CA2472238A1 (en) |
| EA (1) | EA200400716A1 (en) |
| EC (1) | ECSP045200A (en) |
| HR (1) | HRP20040659A2 (en) |
| IL (1) | IL162677A0 (en) |
| IS (1) | IS7310A (en) |
| MA (1) | MA27167A1 (en) |
| MX (1) | MXPA04006573A (en) |
| NO (1) | NO20043457L (en) |
| OA (1) | OA12756A (en) |
| PA (1) | PA8563501A1 (en) |
| PE (1) | PE20030929A1 (en) |
| PL (1) | PL371487A1 (en) |
| TN (1) | TNSN04121A1 (en) |
| TW (1) | TW200302094A (en) |
| UY (1) | UY27615A1 (en) |
| WO (1) | WO2003061652A1 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005051384A1 (en) * | 2003-11-25 | 2005-06-09 | Pfizer Limited | Stabilised pharmaceutical compositions |
| WO2006113247A1 (en) * | 2005-04-18 | 2006-10-26 | Bayer Schering Pharma Aktiengesellschaft | Use of tafi inhibitors for enhanced myocardial reperfusion and facilitated pci |
| US20110213143A1 (en) | 2008-10-29 | 2011-09-01 | Taisho Pharmaceutical Co., Ltd. | Compound having tafia inhibitory activity |
| US8987242B2 (en) | 2008-12-05 | 2015-03-24 | Merck Sharp & Dohme Corp. | Morpholinone compounds as factor IXA inhibitors |
| TW201033184A (en) | 2008-12-05 | 2010-09-16 | Mochida Pharm Co Ltd | Morpholinone compounds as factor IXa inhibitors |
| EP2548871B1 (en) | 2010-03-18 | 2017-07-19 | Daiichi Sankyo Company, Limited | Cycloalkyl-substituted imidazole derivative |
| WO2011115065A1 (en) * | 2010-03-18 | 2011-09-22 | 第一三共株式会社 | Cyclopropanecarboxylic acid derivative |
| JP6461113B2 (en) | 2013-06-10 | 2019-01-30 | サノフイＳａｎｏｆｉ | Macrocyclic urea derivatives as inhibitors of TAFIa, their preparation and use as pharmaceuticals |
| WO2017170460A1 (en) | 2016-03-29 | 2017-10-05 | 第一三共株式会社 | Inflammatory intestinal disease therapeutic agent |
| EP3682881A4 (en) | 2017-09-14 | 2021-08-11 | Daiichi Sankyo Company, Limited | Compound having cyclic structure |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9901572D0 (en) * | 1999-05-03 | 1999-05-03 | Astra Ab | New compounds |
| PL361054A1 (en) * | 2000-08-17 | 2004-09-20 | Pfizer Inc. | Substituted imidazoles as tafia inhibitors |
-
2003
- 2003-01-10 EA EA200400716A patent/EA200400716A1/en unknown
- 2003-01-10 BR BR0307016-6A patent/BR0307016A/en not_active IP Right Cessation
- 2003-01-10 AP APAP/P/2004/003084A patent/AP2004003084A0/en unknown
- 2003-01-10 JP JP2003561596A patent/JP2005520811A/en active Pending
- 2003-01-10 EP EP03700059A patent/EP1467731A1/en not_active Withdrawn
- 2003-01-10 PL PL03371487A patent/PL371487A1/en unknown
- 2003-01-10 IL IL16267703A patent/IL162677A0/en unknown
- 2003-01-10 CA CA002472238A patent/CA2472238A1/en not_active Abandoned
- 2003-01-10 WO PCT/IB2003/000060 patent/WO2003061652A1/en not_active Application Discontinuation
- 2003-01-10 KR KR10-2004-7011370A patent/KR20040077775A/en not_active Application Discontinuation
- 2003-01-10 MX MXPA04006573A patent/MXPA04006573A/en unknown
- 2003-01-10 CN CNA03802599XA patent/CN1620291A/en active Pending
- 2003-01-10 OA OA1200400190A patent/OA12756A/en unknown
- 2003-01-16 TW TW092100889A patent/TW200302094A/en unknown
- 2003-01-17 PE PE2003000058A patent/PE20030929A1/en not_active Application Discontinuation
- 2003-01-20 UY UY27615A patent/UY27615A1/en not_active Application Discontinuation
- 2003-01-21 AR ARP030100165A patent/AR038197A1/en unknown
- 2003-01-22 PA PA20038563501A patent/PA8563501A1/en unknown
-
2004
- 2004-06-14 IS IS7310A patent/IS7310A/en unknown
- 2004-06-30 TN TNP2004000121A patent/TNSN04121A1/en unknown
- 2004-07-15 MA MA27786A patent/MA27167A1/en unknown
- 2004-07-19 HR HR20040659A patent/HRP20040659A2/en not_active Application Discontinuation
- 2004-07-22 EC EC2004005200A patent/ECSP045200A/en unknown
- 2004-08-19 NO NO20043457A patent/NO20043457L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20043457L (en) | 2004-08-19 |
| PL371487A1 (en) | 2005-06-13 |
| UY27615A1 (en) | 2003-08-29 |
| TW200302094A (en) | 2003-08-01 |
| KR20040077775A (en) | 2004-09-06 |
| JP2005520811A (en) | 2005-07-14 |
| AR038197A1 (en) | 2005-01-05 |
| PA8563501A1 (en) | 2004-08-31 |
| CA2472238A1 (en) | 2003-07-31 |
| ECSP045200A (en) | 2004-08-27 |
| PE20030929A1 (en) | 2003-11-05 |
| BR0307016A (en) | 2004-11-03 |
| MA27167A1 (en) | 2005-01-03 |
| AP2004003084A0 (en) | 2004-09-30 |
| TNSN04121A1 (en) | 2006-06-01 |
| IL162677A0 (en) | 2005-11-20 |
| OA12756A (en) | 2006-07-03 |
| WO2003061652A8 (en) | 2004-09-10 |
| EP1467731A1 (en) | 2004-10-20 |
| HRP20040659A2 (en) | 2004-10-31 |
| MXPA04006573A (en) | 2004-10-04 |
| WO2003061652A1 (en) | 2003-07-31 |
| CN1620291A (en) | 2005-05-25 |
| IS7310A (en) | 2004-06-14 |
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