EA200400384A1 - SOLUBLE T-CELL RECEPTOR - Google Patents

SOLUBLE T-CELL RECEPTOR

Info

Publication number
EA200400384A1
EA200400384A1 EA200400384A EA200400384A EA200400384A1 EA 200400384 A1 EA200400384 A1 EA 200400384A1 EA 200400384 A EA200400384 A EA 200400384A EA 200400384 A EA200400384 A EA 200400384A EA 200400384 A1 EA200400384 A1 EA 200400384A1
Authority
EA
Eurasian Patent Office
Prior art keywords
soluble
tcr
chain
cell receptor
domain
Prior art date
Application number
EA200400384A
Other languages
Russian (ru)
Other versions
EA006601B1 (en
Inventor
Бент Карстен Якобсен
Меир Глик
Original Assignee
Авидекс Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0121187A external-priority patent/GB0121187D0/en
Priority claimed from GB0219146A external-priority patent/GB0219146D0/en
Application filed by Авидекс Лимитед filed Critical Авидекс Лимитед
Priority claimed from PCT/GB2002/003986 external-priority patent/WO2003020763A2/en
Publication of EA200400384A1 publication Critical patent/EA200400384A1/en
Publication of EA006601B1 publication Critical patent/EA006601B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

Abstract

Настоящее изобретение обеспечивает получение растворимого Т-лимфоцитного рецептора (soluble T cell receptor, sTCR), который содержит (I) всю α-цепь TCR или ее часть за исключением ее трансмембранного домена и (II) всю β-цепь TCR или ее часть за исключением ее трансмембранного домена. При этом каждый из компонентов (I) и (II) содержит функциональный вариабельный домен и по меньшей мере часть константного домена цепи TCR, и оба они соединены дисульфидной связью, расположенной между остатками аминокислот константных доменов и отсутствующей в нативном TCR.Отчет о международном поиске был опубликован 2003.05.22.The present invention provides a soluble T-lymphocyte receptor (soluble T cell receptor, sTCR), which contains (I) the entire TCR α-chain or part thereof except its transmembrane domain and (II) the entire TCR β-chain or part thereof its transmembrane domain. In addition, each of components (I) and (II) contains a functional variable domain and at least part of the constant domain of the TCR chain, and both are linked by a disulfide bond located between the amino acid residues of the constant domains and not in the native TCR. published 2003.05.22.

EA200400384A 2001-08-31 2002-08-30 Soluble t cell receptor EA006601B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0121187A GB0121187D0 (en) 2001-08-31 2001-08-31 Substances
US40418202P 2002-08-16 2002-08-16
GB0219146A GB0219146D0 (en) 2002-08-16 2002-08-16 Substances
PCT/GB2002/003986 WO2003020763A2 (en) 2001-08-31 2002-08-30 Soluble t cell receptor

Publications (2)

Publication Number Publication Date
EA200400384A1 true EA200400384A1 (en) 2004-08-26
EA006601B1 EA006601B1 (en) 2006-02-24

Family

ID=47682092

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200400384A EA006601B1 (en) 2001-08-31 2002-08-30 Soluble t cell receptor

Country Status (2)

Country Link
KR (1) KR100945977B1 (en)
EA (1) EA006601B1 (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6080840A (en) 1992-01-17 2000-06-27 Slanetz; Alfred E. Soluble T cell receptors

Also Published As

Publication number Publication date
KR100945977B1 (en) 2010-03-09
KR20040039322A (en) 2004-05-10
EA006601B1 (en) 2006-02-24

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

PC4A Registration of transfer of a eurasian patent by assignment
TC4A Change in name of a patent proprietor in a eurasian patent

Designated state(s): AM AZ KZ KG MD TJ TM

PC4A Registration of transfer of a eurasian patent by assignment