EA200400081A1 - ANALYTICAL SYSTEM WITH HIGH PASSAGE CAPACITY - Google Patents

ANALYTICAL SYSTEM WITH HIGH PASSAGE CAPACITY

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Publication number
EA200400081A1
EA200400081A1 EA200400081A EA200400081A EA200400081A1 EA 200400081 A1 EA200400081 A1 EA 200400081A1 EA 200400081 A EA200400081 A EA 200400081A EA 200400081 A EA200400081 A EA 200400081A EA 200400081 A1 EA200400081 A1 EA 200400081A1
Authority
EA
Eurasian Patent Office
Prior art keywords
probes
anchors
combination according
preferred
area
Prior art date
Application number
EA200400081A
Other languages
Russian (ru)
Other versions
EA011415B1 (en
Inventor
Ричард М. Крис
Стефен Фелдер
Original Assignee
Хай Трупут Дженомикс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/888,413 external-priority patent/US20030096232A1/en
Application filed by Хай Трупут Дженомикс, Инк. filed Critical Хай Трупут Дженомикс, Инк.
Publication of EA200400081A1 publication Critical patent/EA200400081A1/en
Publication of EA011415B1 publication Critical patent/EA011415B1/en

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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Данное изобретение относится к композициям, аппаратуре и способам, пригодным для одновременного проведения множества биологических или химических анализов с высокой пропускной способностью с использованием повторяющихся совокупностей зондов. Комбинация по изобретению содержит поверхность, которая включает множество тест-областей, по меньшей мере две из которых и в предпочтительном воплощении по меньшей мере двадцать из которых в основном являются одинаковыми, где каждая из тест-областей содержит совокупность близких якорных молекул. Якоря связаны с бифункциональными линкерами, где каждый включает участок, специфичный по меньшей мере к одному из якорей, и участок, который представляет зонд, специфичный к интересующей мишени. Полученная совокупность зондов используется для анализа на присутствие или определение активности одной или более молекул-мишеней, которые специфически взаимодействуют с зондами. В предпочтительном воплощении тестируемая проба подвергается обработке защитой от нуклеаз перед ее контактированием с комбинацией по изобретению.Отчет о международном поиске был опубликован 2003.12.11.This invention relates to compositions, apparatus, and methods suitable for simultaneously conducting a variety of high throughput biological or chemical analyzes using repetitive sets of probes. A combination according to the invention comprises a surface that includes a plurality of test areas, at least two of which, and in a preferred embodiment, at least twenty of which are basically the same, where each of the test areas contains a collection of nearby anchor molecules. Anchors are associated with bifunctional linkers, where each includes an area specific to at least one of the anchors, and an area that represents a probe specific to the target of interest. The resulting set of probes is used to analyze the presence or determination of the activity of one or more target molecules that specifically interact with the probes. In a preferred embodiment, the test sample is treated with protection from nucleases before it is contacted with the combination according to the invention. The international search report was published 2003.12.11.

EA200400081A 2001-06-26 2002-06-26 Solution for lysis of cells or providing their permeability and methods of detecting a nucleic acid target EA011415B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/888,413 US20030096232A1 (en) 1997-12-19 2001-06-26 High throughput assay system
PCT/US2002/020039 WO2003002750A2 (en) 2001-06-26 2002-06-26 High throughput assay system

Publications (2)

Publication Number Publication Date
EA200400081A1 true EA200400081A1 (en) 2005-06-30
EA011415B1 EA011415B1 (en) 2009-02-27

Family

ID=40849123

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200400081A EA011415B1 (en) 2001-06-26 2002-06-26 Solution for lysis of cells or providing their permeability and methods of detecting a nucleic acid target

Country Status (1)

Country Link
EA (1) EA011415B1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6238869B1 (en) * 1997-12-19 2001-05-29 High Throughput Genomics, Inc. High throughput assay system
US6200781B1 (en) * 1999-06-25 2001-03-13 Integrated Genetic Devices, Ltd. Apparatus, system and method for automated execution and analysis of biological and chemical reactions

Also Published As

Publication number Publication date
EA011415B1 (en) 2009-02-27

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): KZ RU