EA200100126A1 - DERIVATIVES OF HYDROXYPYPECOLATIC HYDROXAMIC ACID AS MMP INHIBITORS - Google Patents

DERIVATIVES OF HYDROXYPYPECOLATIC HYDROXAMIC ACID AS MMP INHIBITORS

Info

Publication number
EA200100126A1
EA200100126A1 EA200100126A EA200100126A EA200100126A1 EA 200100126 A1 EA200100126 A1 EA 200100126A1 EA 200100126 A EA200100126 A EA 200100126A EA 200100126 A EA200100126 A EA 200100126A EA 200100126 A1 EA200100126 A1 EA 200100126A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hydroxypypecolatic
derivatives
hydroxamic acid
mmp inhibitors
cancer
Prior art date
Application number
EA200100126A
Other languages
Russian (ru)
Inventor
Ким Фрэнсис Макклур
Марк Карл Ноу
Майкл Энтони Литейвик
Луис Стэнли Чупэк
Original Assignee
Пфайзер Продактс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Инк.
Publication of EA200100126A1 publication Critical patent/EA200100126A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/54—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Соединение формулы (I), в котором R, R, R, R, R, R, R, R, Rи Ar такие, как определено выше, полезное при лечении состояния, выбранного из группы, состоящей из артрита, рака и других заболеваний, характеризующихся активностью матриксных металлопротеиназ или репролизинов млекопитающих. В дополнение, соединения по настоящему изобретению могут быть использованы в комбинированной терапии с обычными нестероидными противовоспалительными лекарствами (NSAID'S), COX-2 ингибиторами и анальгетиками и в комбинации с цитотоксическими лекарствами, такими как адриамицин, дауномицин, цисплатин, этопозид, таксол, таксотер, и другими алкалоидами, такими как винкристин, при лечении рака.Международная заявка была опубликована вместе с отчетом о международном поиске.The compound of formula (I), wherein R, R, R, R, R, R, R, R, R and Ar are as defined above, is useful in treating a condition selected from the group consisting of arthritis, cancer and other diseases, characterized by the activity of matrix metalloproteinases or mammalian reprolysins. In addition, the compounds of the present invention can be used in combination therapy with conventional nonsteroidal anti-inflammatory drugs (NSAID'S), COX-2 inhibitors and analgesics, and in combination with cytotoxic drugs such as adriamycin, daunomycin, cisplatin, etoposide, taxol, taxotere, and other alkaloids, such as vincristine, in the treatment of cancer. The international application was published along with an international search report.

EA200100126A 1998-08-12 1999-08-05 DERIVATIVES OF HYDROXYPYPECOLATIC HYDROXAMIC ACID AS MMP INHIBITORS EA200100126A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9623298P 1998-08-12 1998-08-12
PCT/IB1999/001388 WO2000009485A1 (en) 1998-08-12 1999-08-05 Hydroxy pipecolate hydroxamic acid derivatives as mmp inhibitors

Publications (1)

Publication Number Publication Date
EA200100126A1 true EA200100126A1 (en) 2001-08-27

Family

ID=22256467

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100126A EA200100126A1 (en) 1998-08-12 1999-08-05 DERIVATIVES OF HYDROXYPYPECOLATIC HYDROXAMIC ACID AS MMP INHIBITORS

Country Status (43)

Country Link
US (2) US6329397B1 (en)
EP (1) EP1104403B1 (en)
JP (1) JP2002522528A (en)
KR (1) KR20010085374A (en)
CN (1) CN1316995A (en)
AP (1) AP2001002070A0 (en)
AR (1) AR019241A1 (en)
AT (1) ATE325791T1 (en)
AU (1) AU766366B2 (en)
BG (1) BG105323A (en)
BR (1) BR9912909A (en)
CA (1) CA2340202C (en)
CZ (1) CZ2001484A3 (en)
DE (1) DE69931266T2 (en)
DZ (1) DZ2870A1 (en)
EA (1) EA200100126A1 (en)
EE (1) EE200100086A (en)
ES (1) ES2263279T3 (en)
GE (1) GEP20033117B (en)
GT (1) GT199900131A (en)
HK (1) HK1040242A1 (en)
HN (1) HN1999000131A (en)
HR (1) HRP20010098A2 (en)
HU (1) HUP0103452A3 (en)
ID (1) ID27840A (en)
IL (1) IL141030A0 (en)
IS (1) IS5813A (en)
MA (1) MA26675A1 (en)
NO (1) NO20010686L (en)
NZ (1) NZ509296A (en)
OA (1) OA11594A (en)
PA (1) PA8479201A1 (en)
PE (1) PE20000951A1 (en)
PL (1) PL346041A1 (en)
SK (1) SK1872001A3 (en)
SV (1) SV1999000123A (en)
TN (1) TNSN99156A1 (en)
TR (1) TR200100474T2 (en)
UA (1) UA59453C2 (en)
UY (1) UY25993A1 (en)
WO (1) WO2000009485A1 (en)
YU (1) YU5201A (en)
ZA (1) ZA200101042B (en)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6846799B1 (en) 1998-08-18 2005-01-25 The Regents Of The University Of California Preventing airway mucus production by administration of EGF-R antagonists
US7354894B2 (en) 1998-08-18 2008-04-08 The Regents Of The University Of California Preventing airway mucus production by administration of EGF-R antagonists
AU754719B2 (en) * 1998-08-31 2002-11-21 Merck & Co., Inc. Method of treating neurodegenerative diseases
US6509337B1 (en) * 1998-09-17 2003-01-21 Pfizer Inc. Arylsulfonyl Hydroxamic Acid derivatives as MMP and TNF inhibitors
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
EP1081137A1 (en) * 1999-08-12 2001-03-07 Pfizer Products Inc. Selective inhibitors of aggrecanase in osteoarthritis treatment
EP1138680A1 (en) * 2000-03-29 2001-10-04 Pfizer Products Inc. Gem substituted sulfonyl hydroxamic acids as MMP inhibitors
JP2001322977A (en) * 2000-05-12 2001-11-20 Kotobuki Seiyaku Kk Pipecolic acid derivative and method for producing the same and pharmaceutical composition containing the same
JP2002105073A (en) * 2000-09-27 2002-04-10 Shionogi & Co Ltd New matrix metalloprotease inhibitor
DOP2002000332A (en) 2001-02-14 2002-08-30 Warner Lambert Co MATRIX METALOPROTEINAS PYRIDINE INHIBITORS
DE60236851D1 (en) 2001-02-14 2010-08-12 Warner Lambert Co Pyrimidinmatrixmetalloproteinaseinhibitoren
PA8539501A1 (en) 2001-02-14 2002-09-30 Warner Lambert Co TRIAZOLO COMPOUNDS AS MMP INHIBITORS
DOP2002000333A (en) 2001-02-14 2002-09-30 Warner Lambert Co DERIVATIVES OF ISOFTALIC ACID AS INHIBITORS OF METALOPROTEINASES OF THE MATRIX
US6924276B2 (en) 2001-09-10 2005-08-02 Warner-Lambert Company Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors
WO2003032999A1 (en) 2001-10-12 2003-04-24 Warner-Lambert Company Llc Alkyne matrix metalloproteinase inhibitors
US6962922B2 (en) 2001-10-12 2005-11-08 Warner-Lambert Company Llc Alkynylated quinazoline compounds
US6894057B2 (en) 2002-03-08 2005-05-17 Warner-Lambert Company Oxo-azabicyclic compounds
CA2494249A1 (en) * 2002-06-26 2004-01-08 Koichi Yokota Novel azasugar derivative and drug containing the same as the active ingredient
WO2004007025A1 (en) * 2002-07-17 2004-01-22 Warner-Lambert Company Llc Combination of an allosteric alkyne inhibitor of matrix metalloproteinase-13 with a selective inhibitor of cyclooxygenase-2 that is not celecoxib or valdecoxib
WO2004006914A1 (en) * 2002-07-17 2004-01-22 Warner-Lambert Company Llc Combination of an allosteric alkyne inhibitor of matrix metalloproteinase-13 with celecoxib or valdecoxib
WO2004014908A1 (en) 2002-08-13 2004-02-19 Warner-Lambert Company Llc Heterobicylcic metalloproteinase inhibitors
JP2006501215A (en) 2002-08-13 2006-01-12 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー Monocyclic derivatives as matrix metalloproteinase inhibitors
WO2004014375A2 (en) 2002-08-13 2004-02-19 Warner-Lambert Company Llc Fused bicyclic metalloproteinase inhibitors
AU2003253186A1 (en) 2002-08-13 2004-02-25 Warner-Lambert Company Llc Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors
AU2003250466A1 (en) 2002-08-13 2004-02-25 Warner-Lambert Company Llc 3-isoquinolinone derivatives as matrix metalloproteinase inhiitors
AU2003250470A1 (en) 2002-08-13 2004-02-25 Warner-Lambert Company Llc Pyrimidinone fused bicyclic metalloproteinase inhibitors
AU2003249531A1 (en) 2002-08-13 2004-02-25 Warner-Lambert Company Llc Azaisoquinoline derivatives as matrix metalloproteinase inhibitors
BR0313384A (en) 2002-08-13 2005-07-12 Warner Lambert Co Chromone derivatives as matrix metalloproteinase inhibitors
PA8578101A1 (en) 2002-08-13 2004-05-07 Warner Lambert Co HETEROBIARILO DERIVATIVES AS METALOPROTEINASE IN MATRIX INHIBITORS
AU2003250471A1 (en) 2002-08-13 2004-02-25 Warner-Lambert Company Llc Pyrimidine-2,4-dione derivatives as matrix metalloproteinase inhibitors
WO2006131836A2 (en) * 2005-03-22 2006-12-14 Innodia Inc. Compounds and compositions for use in the prevention and treatment of obesity and related syndromes
DE602009000550D1 (en) 2008-03-25 2011-02-24 Affectis Pharmaceuticals Ag Novel P2X7R antagonists and their use
AU2010237302A1 (en) 2009-04-14 2011-12-01 Affectis Pharmaceuticals Ag Novel P2X7R antagonists and their use
WO2012110190A1 (en) 2011-02-17 2012-08-23 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012163456A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012163792A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
DE202016007195U1 (en) 2016-11-16 2017-11-17 Bernhard Kohler Current-limiting switching device
WO2020160140A1 (en) * 2019-01-29 2020-08-06 Darsha Llc Compositions and methods for treating pulmonary disease with matrix metalloproteinase inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2218503C (en) * 1995-04-20 2001-07-24 Pfizer Inc. Arylsulfonyl hydroxamic acid derivatives
WO1997020824A1 (en) * 1995-12-08 1997-06-12 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparation
RU2221782C2 (en) * 1996-08-28 2004-01-20 Дзе Проктер Энд Гэмбл Компани Substituted cyclic amine-type metalloprotease inhibitors
TR199901849T2 (en) * 1997-02-03 2000-02-21 Pfizer Products Inc. Arylsulfonylamino hydroxamic acid derivatives.
NZ336836A (en) * 1997-02-11 2001-02-23 Pfizer Arylsulfonyl hydroxamic acid derivatives suitable for a broad range of medicinal treatments
WO1998050348A1 (en) * 1997-05-09 1998-11-12 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses

Also Published As

Publication number Publication date
AU766366B2 (en) 2003-10-16
AP2001002070A0 (en) 2001-03-31
NO20010686D0 (en) 2001-02-09
EP1104403B1 (en) 2006-05-10
YU5201A (en) 2003-07-07
MA26675A1 (en) 2004-12-20
SV1999000123A (en) 2000-07-06
EP1104403A1 (en) 2001-06-06
AU4924799A (en) 2000-03-06
US20030008901A1 (en) 2003-01-09
UY25993A1 (en) 2000-03-31
EE200100086A (en) 2002-08-15
SK1872001A3 (en) 2002-08-06
BR9912909A (en) 2001-05-08
HK1040242A1 (en) 2002-05-31
HN1999000131A (en) 2000-03-24
PE20000951A1 (en) 2000-09-27
NZ509296A (en) 2003-10-31
CZ2001484A3 (en) 2002-05-15
CA2340202A1 (en) 2000-02-24
WO2000009485A1 (en) 2000-02-24
HUP0103452A3 (en) 2002-10-28
ATE325791T1 (en) 2006-06-15
OA11594A (en) 2004-07-11
PL346041A1 (en) 2002-01-14
ES2263279T3 (en) 2006-12-01
DE69931266T2 (en) 2007-02-15
AR019241A1 (en) 2001-12-26
JP2002522528A (en) 2002-07-23
CN1316995A (en) 2001-10-10
TNSN99156A1 (en) 2005-11-10
PA8479201A1 (en) 2000-09-29
IL141030A0 (en) 2002-02-10
DZ2870A1 (en) 2003-12-15
US6329397B1 (en) 2001-12-11
DE69931266D1 (en) 2006-06-14
CA2340202C (en) 2006-02-07
HRP20010098A2 (en) 2002-02-28
GT199900131A (en) 2001-02-02
IS5813A (en) 2001-01-16
NO20010686L (en) 2001-04-09
HUP0103452A2 (en) 2002-04-29
UA59453C2 (en) 2003-09-15
TR200100474T2 (en) 2001-06-21
ZA200101042B (en) 2002-10-07
GEP20033117B (en) 2003-11-25
ID27840A (en) 2001-04-26
KR20010085374A (en) 2001-09-07
BG105323A (en) 2001-10-31

Similar Documents

Publication Publication Date Title
EA200100126A1 (en) DERIVATIVES OF HYDROXYPYPECOLATIC HYDROXAMIC ACID AS MMP INHIBITORS
TR199901849T2 (en) Arylsulfonylamino hydroxamic acid derivatives.
EA199900036A1 (en) METALLIC PROTEASIS INHIBITORS OF MATRIX ON THE BASIS OF PHOSPHINATES, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT
GT199900132A (en) TACE INHIBITORS.
DE69314456D1 (en) Arylsulfonamido-substituted hydroxamic acid derivatives
EA199900641A1 (en) Derivatives of arylsulfonylhydroxamic acid
EA199900139A1 (en) DERIVATIVES OF ARYL SULPHONYLAMINO HYDROXAMIC ACID
ATE197038T1 (en) N-AROYL-GLYCINE HYDROXAMIC ACID DERIVATIVES AND RELATED COMPOUNDS
DE60234577D1 (en) PHARMACEUTICAL MIXTURE FOR THE TREATMENT OF CANCER CONTAINING DIOXOLANE NUCLEOSIDE ANALOGUE
PT911331E (en) SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE
DK1181286T3 (en) 3- (arylsulfonylamino) -tetrahydropyran-3-carboxylic acid hydroxamides
BR9916733A (en) Arylalkanine derivatives, processes for their preparation, their use and pharmaceutical compositions containing them
EA200400709A1 (en) INHIBITORS 11-BETA-HYDROXYSTEROID DEGYDROGENASE TYPE 1
TH14843A (en) HIV protease inhibitors useful in the treatment of AIDS
TH21668A (en) Pharmaceutical mixtures containing quinoline or quinazoline derivatives. And new derivatives of those substances