EA199900339A1 - HUMAN GROWTH GENE AND AREA GENE RESPONSIBLE FOR LOW GROWTH - Google Patents

HUMAN GROWTH GENE AND AREA GENE RESPONSIBLE FOR LOW GROWTH

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Publication number
EA199900339A1
EA199900339A1 EA199900339A EA199900339A EA199900339A1 EA 199900339 A1 EA199900339 A1 EA 199900339A1 EA 199900339 A EA199900339 A EA 199900339A EA 199900339 A EA199900339 A EA 199900339A EA 199900339 A1 EA199900339 A1 EA 199900339A1
Authority
EA
Eurasian Patent Office
Prior art keywords
gene
growth
low
responsible
genes
Prior art date
Application number
EA199900339A
Other languages
Russian (ru)
Inventor
Гудрун Раппольд-Хоербранд
Эрколе Рао
Original Assignee
Гудрун Раппольд-Хоербранд
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Гудрун Раппольд-Хоербранд filed Critical Гудрун Раппольд-Хоербранд
Priority claimed from PCT/EP1997/005355 external-priority patent/WO1998014568A1/en
Publication of EA199900339A1 publication Critical patent/EA199900339A1/en

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  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

В заявке описана выделенная молекула нуклеиновой кислоты, которая кодирует полипептиды, содержащие домен гомеобокса, состоящий из 60 аминокислот и имеющий аминокислотную последовательность [SEQ ID NO:1], и обладает регуляторной активностью в отношении роста человека. Выявлено три новых гена, расположенных в области размером 500 т.п.н. на Х- и Y-хромосоме, имеющей решающее значение для низкого роста. По меньшей мере, один из этих генов ответственен за фенотип низкого роста. кДНК, соответствующая этому гену, может применяться в качестве инструмента диагностики и для дополнительной характеристики молекул, определяющих фенотип низкого роста. Кроме того, идентификация генного продукта гена позволяет предложить новые способы и методы развития улучшенных способов лечения низкого роста.Международная заявка была опубликована вместе с отчетом о международном поиске.The application describes an isolated nucleic acid molecule that encodes polypeptides containing a homeobox domain consisting of 60 amino acids and having the amino acid sequence [SEQ ID NO: 1], and has regulatory activity on human growth. Three new genes have been identified, located in a 500 kb region. on the X and Y chromosomes that are critical for short stature. At least one of these genes is responsible for the low growth phenotype. The cDNA corresponding to this gene can be used as a diagnostic tool and for the additional characterization of molecules that determine the low-growth phenotype. In addition, the identification of the gene product of a gene allows us to propose new ways and methods for developing improved methods for treating low growth. The international application was published along with an international search report.

EA199900339A 1996-10-01 1997-09-29 HUMAN GROWTH GENE AND AREA GENE RESPONSIBLE FOR LOW GROWTH EA199900339A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2763396P 1996-10-01 1996-10-01
EP97100583 1997-01-16
PCT/EP1997/005355 WO1998014568A1 (en) 1996-10-01 1997-09-29 Human growth gene and short stature gene region

Publications (1)

Publication Number Publication Date
EA199900339A1 true EA199900339A1 (en) 1999-12-29

Family

ID=58192426

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900339A EA199900339A1 (en) 1996-10-01 1997-09-29 HUMAN GROWTH GENE AND AREA GENE RESPONSIBLE FOR LOW GROWTH

Country Status (1)

Country Link
EA (1) EA199900339A1 (en)

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