EA199800671A1 - FILLED IN FLOW MATERIAL TRANSFER FOR SOLID-PHASE ANALYSIS - Google Patents

FILLED IN FLOW MATERIAL TRANSFER FOR SOLID-PHASE ANALYSIS

Info

Publication number
EA199800671A1
EA199800671A1 EA199800671A EA199800671A EA199800671A1 EA 199800671 A1 EA199800671 A1 EA 199800671A1 EA 199800671 A EA199800671 A EA 199800671A EA 199800671 A EA199800671 A EA 199800671A EA 199800671 A1 EA199800671 A1 EA 199800671A1
Authority
EA
Eurasian Patent Office
Prior art keywords
affinity
sorption
sorption material
filled
materials
Prior art date
Application number
EA199800671A
Other languages
Russian (ru)
Inventor
Урсула Эрхардт
Кристоф Эрхардт
Original Assignee
Абион Бетайлигунгс-Унд Фервальтунгсгезелльшафт Мбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1996105003 external-priority patent/DE19605003A1/en
Application filed by Абион Бетайлигунгс-Унд Фервальтунгсгезелльшафт Мбх filed Critical Абион Бетайлигунгс-Унд Фервальтунгсгезелльшафт Мбх
Publication of EA199800671A1 publication Critical patent/EA199800671A1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28042—Shaped bodies; Monolithic structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28016—Particle form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28023—Fibres or filaments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28026—Particles within, immobilised, dispersed, entrapped in or on a matrix, e.g. a resin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28033—Membrane, sheet, cloth, pad, lamellar or mat
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28047—Gels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28052—Several layers of identical or different sorbents stacked in a housing, e.g. in a column
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28078—Pore diameter
    • B01J20/28085—Pore diameter being more than 50 nm, i.e. macropores
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Dispersion Chemistry (AREA)
  • Nanotechnology (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Ceramic Products (AREA)

Abstract

Предложен сорбционный материал в виде формованного тела, свободных насыпок частиц, геля, мембраны или утопленного в мембранах материала или дисперсного материала, причем сорбционный материал способен неспецифически связывать материалы сродства и является проницаемым для текучей среды. Сорбционный материал имеет поры среднего диаметра от 0,1 до 100 мкм, неспецифически связывает материалы сродства при их протекании через сорбционный материал и стандартизирован настолько, что определенный единичный объем, заполненный сорбционным материалом, связывает подлежащий сорбционному связыванию материал сродства при разовом равномерном протекании определенного количества раствора материала сродства с определенной концентрацией в таком количестве, которое колеблется при нескольких статистически существенных процессах заполнения на среднюю величину заполнения, не превышающую ±40%, и что при последующем блокировании свободных неспецифических сорбционных участков и при нескольких, следующих за ним процессах протекания по сорбционному материалу, таких как промывка наполненного материалом сродства сорбционного материала или подача реакционных материалов сродства в указанную зону, связанное количество сохраняется постоянным.Международная заявка была опубликована вместе с отчетом о международном поиске.A sorption material in the form of a molded body, free fillings of particles, a gel, a membrane, or a material dispersed in a membrane or a dispersed material is proposed, the sorption material being capable of non-specifically binding affinity materials and is permeable to a fluid. The sorption material has pores of average diameter from 0.1 to 100 microns, binds affinity materials nonspecifically as they flow through the sorption material, and is standardized so that a certain unit volume filled with the sorption material binds the affinity material to be sorptively bonded with a single uniform flow of a certain amount of solution affinity material with a certain concentration in an amount that varies with a few statistically significant processes for an average filling amount not exceeding ± 40%, and that with subsequent blocking of free non-specific sorption sites and with several subsequent processes following the sorption material, such as washing the affinity of the sorption material filled with material or feeding the affinity reaction materials into the specified zone , the bound number is kept constant. The international application was published with the international search report.

EA199800671A 1996-01-30 1997-01-30 FILLED IN FLOW MATERIAL TRANSFER FOR SOLID-PHASE ANALYSIS EA199800671A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1996105003 DE19605003A1 (en) 1996-01-30 1996-01-30 Sorption material has pores down to submicron size
DE19615707 1996-04-22
PCT/EP1997/000405 WO1997028448A1 (en) 1996-01-30 1997-01-30 Carrier material loadable by a through flow for solid phase assays

Publications (1)

Publication Number Publication Date
EA199800671A1 true EA199800671A1 (en) 1999-02-25

Family

ID=26022811

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800671A EA199800671A1 (en) 1996-01-30 1997-01-30 FILLED IN FLOW MATERIAL TRANSFER FOR SOLID-PHASE ANALYSIS

Country Status (8)

Country Link
EP (1) EP0879416A1 (en)
JP (1) JP2000507347A (en)
CN (1) CN1214771A (en)
AU (1) AU1597297A (en)
BR (1) BR9707232A (en)
DE (2) DE29701511U1 (en)
EA (1) EA199800671A1 (en)
WO (1) WO1997028448A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997049992A1 (en) * 1996-06-25 1997-12-31 Abion Beteiligungs- Und Verwaltungsgesellschaft Mbh Use of a carrier material for sample preparation and detection for a genetic-engineering analysis process
CN1956779B (en) * 2004-05-24 2010-04-14 株式会社资生堂 Affinity particle and affinity separation method
JP5423965B2 (en) * 2007-05-30 2014-02-19 Ｊｓｒ株式会社 Non-specific adsorption inhibitor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7033787A (en) * 1986-05-30 1987-12-22 Quidel Enzyme immunoassay device
DE4126436A1 (en) * 1990-09-17 1992-03-19 Abion Ohg DISPOSABLE REACTION TUBE FOR SOLID-PHASE IMMUNAL ANALYTICS AND METHOD FOR MEASURING COMPONENTS DETERMINABLE BY IMMUNE REACTIONS
DE4115277A1 (en) * 1991-05-10 1992-11-12 Roehm Guenter H INTERCHANGEABLE DEVICE FOR LATHE CHUCK Jaws
DE4208732C2 (en) * 1992-03-18 1995-04-27 Abion Ohg Disposable reaction vessel for solid phase immunoanalysis and method for measuring components that can be determined via immune reactions
WO1995019569A1 (en) * 1994-01-13 1995-07-20 Abion Beteiligungs- Und Verwaltungsgesellschaft Mbh Reaction columns for simultaneous multiple measurement and method

Also Published As

Publication number Publication date
BR9707232A (en) 1999-07-20
WO1997028448A1 (en) 1997-08-07
AU1597297A (en) 1997-08-22
CN1214771A (en) 1999-04-21
JP2000507347A (en) 2000-06-13
DE29701511U1 (en) 1998-05-28
DE19780059D2 (en) 1999-08-12
EP0879416A1 (en) 1998-11-25

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