EA199800103A1 - DIGLICOULATED 1,2-DIOLS AS THE PSIAL INTEGRATION OF CIALIL-LEWIS X AND CIALIL-LEWIS A - Google Patents

DIGLICOULATED 1,2-DIOLS AS THE PSIAL INTEGRATION OF CIALIL-LEWIS X AND CIALIL-LEWIS A

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Publication number
EA199800103A1
EA199800103A1 EA199800103A EA199800103A EA199800103A1 EA 199800103 A1 EA199800103 A1 EA 199800103A1 EA 199800103 A EA199800103 A EA 199800103A EA 199800103 A EA199800103 A EA 199800103A EA 199800103 A1 EA199800103 A1 EA 199800103A1
Authority
EA
Eurasian Patent Office
Prior art keywords
lewis
cialil
psial
diglicoulated
diols
Prior art date
Application number
EA199800103A
Other languages
Russian (ru)
Other versions
EA001356B1 (en
Inventor
Хартмуф Христиан Колб
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA199800103A1 publication Critical patent/EA199800103A1/en
Publication of EA001356B1 publication Critical patent/EA001356B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/207—Cyclohexane rings not substituted by nitrogen atoms, e.g. kasugamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Соединения формулы Iв котором Х представляет остаток негликозидного алифатического 1,2-диола; Rпредставляет метил в S-конфигурации, замещенный одним карбоксильным остатком и одним другим заместителем; a Rпредставляет водород, C-Cалкил или Cарил; причем указанные соединения являются заменителями сиалил-Lewis Х- и сиалил-Lewis A-сахаров.Международная заявка была опубликована вместе с отчетом о международном поиске.Compounds of formula I wherein X represents a non-glycoside aliphatic 1,2-diol residue; R5 is methyl in the S-configuration, substituted by one carboxyl residue and one other substituent; a R 5 is hydrogen, C 1-4 alkyl or Caryl; moreover, these compounds are substitutes for sialyl-Lewis X-and sialyl-Lewis A-sugars. The international application was published together with an international search report.

EA199800103A 1995-06-29 1996-06-26 Diglycosylated 1,2-diols as mimetics of sialyl-lewis x and sialyl-lewis a EA001356B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH191495 1995-06-29
PCT/EP1996/002785 WO1997001569A1 (en) 1995-06-29 1996-06-26 Diglycosylated 1,2-diols as mimetics of sialyl-lewis x and sialyl-lewis a

Publications (2)

Publication Number Publication Date
EA199800103A1 true EA199800103A1 (en) 1998-08-27
EA001356B1 EA001356B1 (en) 2001-02-26

Family

ID=4221546

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800103A EA001356B1 (en) 1995-06-29 1996-06-26 Diglycosylated 1,2-diols as mimetics of sialyl-lewis x and sialyl-lewis a

Country Status (19)

Country Link
EP (1) EP0836610A1 (en)
JP (1) JPH11508548A (en)
KR (1) KR19990028543A (en)
CN (1) CN1196731A (en)
AU (1) AU707474B2 (en)
BR (1) BR9609285A (en)
CA (1) CA2224346A1 (en)
CZ (1) CZ419797A3 (en)
EA (1) EA001356B1 (en)
HU (1) HUP9801805A3 (en)
IL (1) IL118740A0 (en)
MX (1) MX9800218A (en)
NO (1) NO976065L (en)
NZ (1) NZ311686A (en)
PL (1) PL324258A1 (en)
SI (1) SI9620099A (en)
SK (1) SK177897A3 (en)
TR (1) TR199701728T1 (en)
WO (1) WO1997001569A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60144284D1 (en) 2000-11-01 2011-05-05 Millennium Pharm Inc NITROGENIC HETEROCYCLIC COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
EP1577289A1 (en) 2004-03-18 2005-09-21 Revotar Biopharmaceuticals AG Non-glycosylated/-glycosidic/-peptidic small molecule selectin inhibitors for the treament of inflammatory disorders
SI2264043T1 (en) 2005-09-02 2018-01-31 Glycomimetics, Inc. Heterobifunctional pan-selectin inhibitors
EP1764093A1 (en) 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel aromatic compounds and their use in medical applications
EP1764095A1 (en) 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel nitrocatechol derivatives having selectin ligand activity
EP1764096A1 (en) 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel phloroglucinol derivatives having selectin ligand activity
WO2008060378A2 (en) * 2006-10-12 2008-05-22 Glycomimetics, Inc. Glycomimetic replacements for hexoses and n-acetyl hexosamines
EP2457573A1 (en) * 2007-02-09 2012-05-30 GlycoMimetics, Inc. Methods of use of glycomimetics with replacements for hexoses and N-Acetyl hexosamines
WO2009126556A1 (en) 2008-04-08 2009-10-15 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
CA2858099C (en) 2011-12-22 2020-12-15 Glycomimetics, Inc. E-selectin antagonist compounds, compositions, and methods of use
WO2014089269A1 (en) 2012-12-07 2014-06-12 Glycomimetics, Inc. Compounds, compositions and methods using e-selectin antagonists for mobilization of hematopoietic cells
WO2016089872A1 (en) 2014-12-03 2016-06-09 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors
CA3009836A1 (en) 2016-01-22 2017-07-27 Glycomimetics, Inc. Glycomimetic inhibitors of pa-il and pa-iil lectins
WO2017151708A1 (en) 2016-03-02 2017-09-08 Glycomimetics, Inc. Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
EP3497131B1 (en) 2016-08-08 2022-03-09 GlycoMimetics, Inc. Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4.
US11072625B2 (en) 2016-10-07 2021-07-27 Glycomimetics, Inc. Highly potent multimeric e-selectin antagonists
JP7272956B2 (en) 2017-03-15 2023-05-12 グリコミメティクス， インコーポレイテッド Galactopyranosyl-cyclohexyl derivatives as E-selectin antagonists
WO2019108750A1 (en) 2017-11-30 2019-06-06 Glycomimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
CN111566117A (en) 2017-12-29 2020-08-21 糖模拟物有限公司 Heterobifunctional inhibitors of E-selectin and galectin-3
CN111867601A (en) 2018-03-05 2020-10-30 糖模拟物有限公司 Methods for treating acute myeloid leukemia and related disorders
WO2020139962A1 (en) 2018-12-27 2020-07-02 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectin and galectin-3

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5326752A (en) * 1991-11-27 1994-07-05 Glycomed Incorporated Substituted lactose and lactosamine derivatives as cell adhesion inhibitors
WO1993023031A1 (en) * 1992-05-08 1993-11-25 The Biomembrane Institute Multivalent mimetics and peptide mimetics for blocking carbohydrate-dependent cellular interaction and for eliciting anticarbohydrate t-cell response
CA2100412A1 (en) * 1992-07-15 1994-01-16 Yutaka Yamada Glycolipid derivatives

Also Published As

Publication number Publication date
BR9609285A (en) 1999-05-11
WO1997001569A1 (en) 1997-01-16
CN1196731A (en) 1998-10-21
JPH11508548A (en) 1999-07-27
AU6305396A (en) 1997-01-30
IL118740A0 (en) 1996-10-16
AU707474B2 (en) 1999-07-08
EA001356B1 (en) 2001-02-26
EP0836610A1 (en) 1998-04-22
SK177897A3 (en) 1998-08-05
SI9620099A (en) 1998-08-31
CA2224346A1 (en) 1997-01-16
NO976065L (en) 1998-02-17
TR199701728T1 (en) 1998-03-21
MX9800218A (en) 1998-07-31
NZ311686A (en) 2000-01-28
NO976065D0 (en) 1997-12-23
KR19990028543A (en) 1999-04-15
HUP9801805A3 (en) 2002-01-28
HUP9801805A2 (en) 1998-12-28
CZ419797A3 (en) 1998-06-17
PL324258A1 (en) 1998-05-11

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU